7-Methoxy-1-Naphthaleneacetic Acid Ethyl Ester CAS 6836-21-1 Purity >99.0% (GC) Agomelatine Intermediate

Inkcazelo emfutshane:

Igama: 7-Methoxy-1-Naphthaleneacetic Acid Ethyl Ester

Izithethantonye: Ethyl 2-(7-Methoxynaphthalen-1-yl) acetate

CAS: 6836-21-1

Ubunyulu: >99.0% (GC)

Imbonakalo: Ulwelo oluMthubi oluKhalazayo

Umbindi weAgomelatine (CAS: 138112-76-2)

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Iinkcukacha zeMveliso

Iimveliso ezinxulumeneyo

Iithegi zeMveliso

Inkcazo:

UMvelisi oPhambili kunye noMboneleli we-Agomelatine Intermediates
Agomelatine CAS 138112-76-2
I-7-Methoxy-1-Tetralone CAS 6836-19-7
7-Methoxy-1-Naphthaleneacetic Acid CAS 6836-22-2
7-Methoxy-1-Naphthylacetonitrile CAS 138113-08-3
7-Methoxy-1-Naphthaleneacetic Acid Ethyl Ester CAS 6836-21-1
Please contact: alvin@ruifuchem.com

Iipropati zeMichiza:

Igama leMchiza 7-Methoxy-1-Naphthaleneacetic Acid Ethyl Ester
Izithethantonye I-Ethyl 2-(7-Methoxynaphthalen-1-yl)i-acetate
Inombolo yeCAS 6836-21-1
Inombolo yeCAT RF2687
Ubume beStokhwe Kwi-Stock, iMveliso yoMveliso ukuya kwiiToni
Ifomula yeemolekyuli C15H16O3
Ubunzima beMolekyuli 244.29
Uphawu Ruifu Chemical

Iinkcukacha:

Into Iinkcukacha
Imbonakalo Ulwelo oluMthubi oluKhanyayo oluNgaphandle
Ubunyulu / Indlela yokuHlalutya >99.0% (GC)
Amanzi (nguKarl Fischer) <0.50%
Izinto ezinxulumeneyo <1.00%
I-Infrared Spectrum Iyahambelana neSakhiwo
NMR Spectrum Iyahambelana neSakhiwo
Umgangatho woVavanyo Umgangatho woShishino
Ukusetyenziswa I-Pharmaceutical Intermediate ye-Agomelatine (CAS: 138112-76-2)

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Isicelo:

I-7-Methoxy-1-Naphthaleneacetic Acid Ethyl Ester (CAS: 6836-21-1) i-organic synthetic intermediate esebenzayo, ingasetyenziswa njenge-pharmaceutical intermediate ye-Agomelatine (CAS: 138112-76-2).I-Agomelatine, ephuhliswe yinkampani ye-French Servier, yi-melatonin receptors yokuqala yehlabathi i-MT1 kunye neklasi ye-agonist ye-MT2 ye-antidepressants.Isebenza kunyango lwezigulane zabantu abadala abanoxinzelelo olunzima.I-Agomelatine lichiza lokuthomalalisa uxinzelelo.I-Agomelatine yi-agonist ye-melatonin (MT) receptors kunye ne-derivative ye-melatonin.Ibophelela kwi-MT1 kunye ne-MT2 i-receptors (i-Kis = 0.14 kunye ne-0.41 nM, ngokulandelanayo) kwaye inexabiso le-EC50 le-0.1 nM kwi- [35S] i-GTPγS yokubopha i-assay usebenzisa iiseli ze-CHO ezibonisa i-MT2 receptors.Ihlelwa njenge-norepinephrine-dopamine disinhibitor (NDDI) ngenxa yokuchasana kwayo ne-5-HT2C receptor.Ukusebenza kwee-receptors ze-5-HT2C nge-serotonin inqanda i-dopamine kunye nokukhululwa kwe-norepinephrine.

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