7-Methoxy-1-Naphthaleneacetic Acid Ethyl Ester CAS 6836-21-1 Purity >99.0% (GC) Agomelatine Intermediate
UMvelisi oPhambili kunye noMboneleli we-Agomelatine Intermediates
Agomelatine CAS 138112-76-2
I-7-Methoxy-1-Tetralone CAS 6836-19-7
7-Methoxy-1-Naphthaleneacetic Acid CAS 6836-22-2
7-Methoxy-1-Naphthylacetonitrile CAS 138113-08-3
7-Methoxy-1-Naphthaleneacetic Acid Ethyl Ester CAS 6836-21-1
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Igama leMchiza | 7-Methoxy-1-Naphthaleneacetic Acid Ethyl Ester |
Izithethantonye | I-Ethyl 2-(7-Methoxynaphthalen-1-yl)i-acetate |
Inombolo yeCAS | 6836-21-1 |
Inombolo yeCAT | RF2687 |
Ubume beStokhwe | Kwi-Stock, iMveliso yoMveliso ukuya kwiiToni |
Ifomula yeemolekyuli | C15H16O3 |
Ubunzima beMolekyuli | 244.29 |
Uphawu | Ruifu Chemical |
Into | Iinkcukacha |
Imbonakalo | Ulwelo oluMthubi oluKhanyayo oluNgaphandle |
Ubunyulu / Indlela yokuHlalutya | >99.0% (GC) |
Amanzi (nguKarl Fischer) | <0.50% |
Izinto ezinxulumeneyo | <1.00% |
I-Infrared Spectrum | Iyahambelana neSakhiwo |
NMR Spectrum | Iyahambelana neSakhiwo |
Umgangatho woVavanyo | Umgangatho woShishino |
Ukusetyenziswa | I-Pharmaceutical Intermediate ye-Agomelatine (CAS: 138112-76-2) |
Iphakheji: Fluorinated Ibhotile, 25kg / umphanda, okanye ngokwemfuno umthengi
Imeko yoGcino:Gcina kwizikhongozeli ezivaliweyo kwindawo epholileyo neyomileyo;Khusela ukukhanya kunye nokufuma
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I-7-Methoxy-1-Naphthaleneacetic Acid Ethyl Ester (CAS: 6836-21-1) i-organic synthetic intermediate esebenzayo, ingasetyenziswa njenge-pharmaceutical intermediate ye-Agomelatine (CAS: 138112-76-2).I-Agomelatine, ephuhliswe yinkampani ye-French Servier, yi-melatonin receptors yokuqala yehlabathi i-MT1 kunye neklasi ye-agonist ye-MT2 ye-antidepressants.Isebenza kunyango lwezigulane zabantu abadala abanoxinzelelo olunzima.I-Agomelatine lichiza lokuthomalalisa uxinzelelo.I-Agomelatine yi-agonist ye-melatonin (MT) receptors kunye ne-derivative ye-melatonin.Ibophelela kwi-MT1 kunye ne-MT2 i-receptors (i-Kis = 0.14 kunye ne-0.41 nM, ngokulandelanayo) kwaye inexabiso le-EC50 le-0.1 nM kwi- [35S] i-GTPγS yokubopha i-assay usebenzisa iiseli ze-CHO ezibonisa i-MT2 receptors.Ihlelwa njenge-norepinephrine-dopamine disinhibitor (NDDI) ngenxa yokuchasana kwayo ne-5-HT2C receptor.Ukusebenza kwee-receptors ze-5-HT2C nge-serotonin inqanda i-dopamine kunye nokukhululwa kwe-norepinephrine.