7-Methoxy-1-Naphthylacetonitrile CAS 138113-08-3 Ucoceko >99.0% (HPLC) Agomelatine Intermediate
UMvelisi oPhambili kunye noMboneleli we-Agomelatine Intermediates
Agomelatine CAS 138112-76-2
I-7-Methoxy-1-Tetralone CAS 6836-19-7
7-Methoxy-1-Naphthaleneacetic Acid CAS 6836-22-2
7-Methoxy-1-Naphthylacetonitrile CAS 138113-08-3
7-Methoxy-1-Naphthaleneacetic Acid Ethyl Ester CAS 6836-21-1
Please contact: alvin@ruifuchem.com
| Igama leMchiza | 7-Methoxy-1-Naphthylacetonitrile |
| Izithethantonye | I-7-Methoxy-1-Naphthylmethylcyanide;7-Methoxy-1-Naphthaleneacetinitrile;I-1-Cyanomethyl-7-Methoxynaphthalene;I-2-(7-Methoxy-1-Naphthyl)i-acetonitrile;I-2-(7-Methoxynaphthalen-1-yl) i-acetonitrile;Ukungacoceki kwe-Agomelatine 12;I-Agomelatine ePhakathi 1 |
| Inombolo yeCAS | 138113-08-3 |
| Inombolo yeCAT | RF2504 |
| Ubume beStokhwe | KwiSitokhwe, Umthamo weMveliso iiToni ezingama-30 ngenyanga |
| Ifomula yeemolekyuli | C13H11NO |
| Ubunzima beMolekyuli | 197.24 |
| Indawo yokunyibilika | 83.0 ukuba 86.0℃ |
| Ukuxinana | 1.135±0.06 g/cm3 |
| Refractive Index n20/D | 1.44 |
| Ukunyibilika | Inyibilika kwiMethanol |
| Uphawu | Ruifu Chemical |
| Into | Iinkcukacha |
| Imbonakalo | Umgubo oMthubi oKhanya |
| Ubunyulu / Indlela yokuHlalutya | >99.0% (HPLC) |
| Indawo yokunyibilika | 83.0~86.0℃ |
| Ilahleko ekomisweni | <0.50% |
| Intsalela kwi-Ignition | <0.20% |
| Ukungacoceki Okukodwa | <0.50% |
| Ukungcola ngokupheleleyo | <1.00% |
| Iintsimbi ezinzima | <20ppm |
| Proton NMR Spectrum | Iyahambelana neSakhiwo |
| Umgangatho woVavanyo | Umgangatho woShishino |
| Ukusetyenziswa | abaPhakathi bamayeza;I-Agomelatine ePhakathi |
Iphakheji: Ibhotile, ingxowa yefoyile yeAluminiyam, 25kg/Igubu lekhadibhodi, okanye ngokwemfuno yomthengi
Imeko yoGcino:Gcina kwizikhongozeli ezivaliweyo kwindawo epholileyo neyomileyo;Khusela ukukhanya kunye nokufuma
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I-7-Methoxy-1-Naphthylacetonitrile (CAS: 138113-08-3) iphakathi kwe-Agomelatine (CAS: 138112-76-2).I-Agomelatine, ephuhliswe yinkampani ye-French Servier, yi-melatonin receptors yokuqala yehlabathi i-MT1 kunye neklasi ye-agonist ye-MT2 ye-antidepressants.I-Agomelatine isebenza kunyango lwezigulane ezikhulileyo ezinoxinzelelo olunzima.I-Agomelatine i-antidepressant entsha kunye nezenzo ezikhethiweyo ze-agonist kwi-melatonin receptors kunye nesenzo esichasayo esikhethiweyo kwi-serotonin 5HT-2C receptors.Ayichaphazeli ukuthathwa kwe-serotonin, i-noradrenaline okanye i-dopamine.I-Agomelatine inganceda ukulawula 'iwotshi yomzimba' (i-circadian rhythm) kunye neenzuzo ezilungileyo kwimood kunye noxinzelelo lwe-sleein I-Agomelatine isetyenziswa kunyango lokudakumba okanye ukunceda ukuthintela ukudakumba ukuba kubuye, kwaye ifumaneka yodwa ngomyalelo kagqirha.I-Agomelatine - Ukugula Ngengqondo Enye iklasi "ye-blockbuster" yamachiza.I-Agomelatine ine-antidepressant, i-anti-anxiety, ilungelelanisa isigqi sokulala kunye nokulawula indima yewashi yezinto eziphilayo, kunye nokusabela kwayo okubi, ukusebenza ngokwesondo ngaphandle kwemiphumo emibi, kwaye akukho mpendulo yokurhoxisa.I-Agomelatine inefuthe elihle kwizigulane ezinoxinzelelo, kwaye ukusabela okubi kuncinci kakhulu.Idosi ecetyiswayo ye-Agomelatine idla ngokuba yi-25mg yonke imihla kwisiqingatha seyure phambi kokuba ulale.
