I-Ac-HMBA-Linker CAS 15561-46-3 4-(Acetoxymethyl)benzoic Acid Purity>98.0% (HPLC)

Inkcazelo emfutshane:

4-(Acetoxymethyl) benzoic Acid

Izithethantonye: Ac-HMBA-Linker

CAS: 15561-46-3

Ubunyulu: >98.0% (HPLC)

Imbonakalo: Mhlophe ukuya kwi-Off-White Powder

Izinxulumanisi zeSigaba esiSolid iSnthesis

Qhagamshelana: UGqr. Alvin Huang

Iselula/Wechat/WhatsApp: +86-15026746401

E-Mail: alvin@ruifuchem.com


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Inkcazo:

I-Shanghai Ruifu Chemical Co., Ltd. ngumenzi ohamba phambili we-4- (Acetoxymethyl) benzoic Acid (Ac-HMBA-Linker) (i-CAS: 15561-46-3) enomgangatho ophezulu.I-Ruifu Chemical ibonelela ngothotho lwamakhonkco okudibanisa kwisigaba esiqinileyo.I-Ruifu inokubonelela ngenkonzo yehlabathi jikelele, ixabiso elikhuphisanayo, amanani amancinci kunye nesixa esikhulu esikhoyo.Thenga i-Ac-HMBA-Linker,Please contact: alvin@ruifuchem.com

Iipropati zeMichiza:

Igama leMchiza 4-(Acetoxymethyl) benzoic Acid
Izithethantonye I-Ac-HMBA-Linker;4-[(Acetyloxy)methyl]benzoic Acid;I-4-Acetoxymethylbenzoic Acid
Ubume beStokhwe Ikhona evenkileni
Inombolo yeCAS 15561-46-3
Ifomula yeemolekyuli C10H10O4
Ubunzima beMolekyuli 194.18 g/mol
Indawo yokunyibilika 123.0 ~ 124.0℃
Ukuxinana 1.254±0.06 g/cm3
Ugcino Temp. Indawo epholileyo neyomileyo (2~8℃)
I-COA kunye ne-MSDS Iyafumaneka
Udidi Izinxulumanisi zeSigaba esiSolid iSnthesis
Uphawu Ruifu Chemical

Iinkcukacha:

Izinto ImiGangatho yokuHlola Iziphumo
Imbonakalo Mhlophe ukuya kwi-Off-White Powder Iyahambelana
Ubunyulu / Indlela yokuHlalutya >98.0% (HPLC) 99.59%
I-1 H NMR Spectrum Ngokungqinelana noLwakhiwo Iyahambelana
Ukuqukumbela Imveliso ivavanyiwe kwaye iyahambelana neenkcukacha

Ukupakishwa/uGcino/Ukuhambisa ngenqanawe:

Umqulu:Ibhotile yeFluoride, ibhotile yeglasi, okanye ngokwemfuno yomthengi.
Imeko yoGcino:Gcina kwizikhongozeli ezivaliweyo kwindawo yokugcina impahla epholileyo neyomileyo (2~8℃) kude nezinto ezingahambelaniyo.Khusela ukukhanya kunye nokufuma.
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Umgangatho ophezulu: Kusekwe inkqubo epheleleyo yokuqinisekisa umgangatho

FAQ:

Ukuthenga njani?Nceda uqhagamshelaneDr. Alvin Huang: sales@ruifuchem.com or alvin@ruifuchem.com 

Amava Eminyaka Eli-15?Sineminyaka engaphezu kwe-15 yamava ekwenziweni nasekuthumeleni kumazwe angaphandle uluhlu olubanzi oluphezulu lwamayeza aphakathi okanye amachiza alungileyo.

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Amaxwebhu?Emva kwenkonzo yokuthengisa: I-COA, i-MOA, i-ROS, i-MSDS, njl.

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Isicelo:

I-4-(i-Acetoxymethyl) i-benzoic Acid (i-Ac-HMBA-Linker) (i-CAS: i-15561-46-3), izixhumanisi ze-synthesis yesigaba esiqinileyo.Isiseko se-labile ye-4-hydroxymethylbenzoic acid (HMBA) ikhonkco, isuswe ngokufanelekileyo kwi-pH = 10.Ikhonkco ye-HMBA yaboniswa ukuba izinzile kwiimeko ezifunekayo kwi-native chemical ligation, ukuguqulwa okulandelayo kunye nokucocwa kokugqibela.I-benzyl ester, eyenza i-HMBA ikhonkco kunye ne-amino acid yokuqala, izinzile kwi-piperidine, esetyenziselwa ukususwa kweqela le-Fmoc, okwenza uxhulumaniso lusebenze kwi-chemical elongation ye-peptide sequence kunye nezicwangciso ze-Fmoc.Uluhlu olukhulu lwe-C-terminally modified peptides lufunyenwe nge-nucleophilic cleavage ye-ester bond kwisigaba esiqinileyo se-peptide esters ye-4-hydroxymethyl benzamide (HMBA).Iindlela eziphuhlisiwe zibonelela ngeepeptides, i-C-terminally functionalized njenge-esters, i-amides kunye ne-thioesters, ngokucoceka okuphezulu ngokuthe ngqo kwi-resin kwisinyathelo esisodwa sokusabela.I-4-hydroxymethylbenzoic acid linkage, eyayicatshulwe yi-ammonolysis kwi-isopropanol, yanika imodeli ye-peptide 1 kwisivuno esihle ngokubanzi (53% kubandakanywa nokusebenza).

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