Afatinib Dimaleate CAS 850140-73-7 Ubunyulu > 99.5% (HPLC) API
I-Ruifu Chemical Supply Intermediates ye-Afatinib
Afatinib CAS 439081-18-2
Afatinib Dimaleate CAS 850140-73-7
(S)-(+)-3-Hydroxytetrahydrofuran CAS 86087-23-2
(Dimethylamino)i-acetaldehyde I-Diethyl Acetal CAS 3616-56-6
trans-4-Dimethylaminocrotonic Acid Hydrochloride CAS 848133-35-7
I-Diethylphosphonoacetic Acid CAS 3095-95-2
7-Fluoro-6-Nitroquinazolin-4 (1H)-enye CAS 162012-69-3
I-7-Chloro-6-Nitro-4-Hydroxyquinazoline CAS 53449-14-2
N-(3-Chloro-4-Fluorophenyl)-7-Fluoro-6-Nitroquinazolin-4-Amine CAS 162012-67-1
(S)-N4-(3-Chloro-4-Fluorophenyl)-7-((Tetrahydrofuran-3-yl)oxy)quinazoline-4,6-DiamineI-CAS 314771-76-1
(S)-N-(3-Chloro-4-Fluorophenyl)-6-Nitro-7-((Tetrahydrofuran-3-yl)oxy)quinazolin-4-AmineI-CAS 314771-88-5
Igama leMchiza | Afatinib Dimaleate |
Izithethantonye | BIBW2992 Dimaleate;(S,E)-N-(4-(3-Chloro-4-Fluorophenylamino)-7-(Tetrahydrofuran-3-yloxy)quinazolin-6-yl)-4-(dimethylamino)kodwa-2-Enamide Dimaleate |
Inombolo yeCAS | 618-89-3 |
Inombolo yeCAT | RF-PI2032 |
Ubume beStokhwe | Kwi-Stock, iMveliso yoMveliso ukuya kwiiToni |
Ifomula yeemolekyuli | I-C32H33ClFN5O11 |
Ubunzima beMolekyuli | 718.08 |
Uvakalelo | Ukungenwa kukufuma |
Uphawu | Ruifu Chemical |
Into | Iinkcukacha |
Imbonakalo | Mhlophe ukuya kwi-Off-White Powder |
Ubunyulu / Indlela yokuHlalutya | >99.5% (HPLC) |
Ilahleko ekomisweni | <0.50% |
Intsalela kwi-Ignition | <0.10% |
Ukungacoceki okuphezulu okukodwa | <0.30% |
Ukungcola ngokupheleleyo | <0.50% |
Iintsimbi ezinzima (njenge Pb) | ≤20ppm |
I-Infrared Spectrum | Iyahambelana neSakhiwo |
NMR | Iyahambelana neSakhiwo |
Umgangatho woVavanyo | Umgangatho woShishino |
Beka ubomi kwishelufa | Iinyanga ezingama-24 ukuba zigcinwe ngokufanelekileyo |
Ukusetyenziswa | API |
Iphakheji: Ibhotile, ingxowa yefoyile yeAluminiyam, 25kg/Igubu lekhadibhodi, okanye ngokwemfuno yomthengi
Imeko yoGcino:Gcina kwizikhongozeli ezivaliweyo kwindawo epholileyo neyomileyo;Khusela ukukhanya kunye nokufuma
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I-Afatinib Dimaleate (i-CAS: 850140-73-7), ifom ye-dimaleate yetyuwa ye-afanitib, i-agent ekhoyo yomlomo ye-antineoplastic.I-Afatinib Dimaleate yi-EGFR inhibitor ye-family inhibitor engenakuguqulwa kunye ne-IC50s ye-0.5 nM, 0.4 nM, 10 nM kunye ne-14 nM ye-EGFRwt, EGFRL858R, EGFRL858R/T790M kunye ne-HER2, ngokulandelanayo.I-Afatinib Dimaleate iboniswa kunyango lodidi lokuqala lwezigulane ezinomhlaza wemiphunga we-metastatic ongeyonxalenye encinci yeseli (NSCLC) enamathumba ane-epidermal growth factor receptor (EGFR) exon 19 deletions or exon 21 (L858R) substitution substitutions njengoko ifunyenwe yi-FDA- uvavanyo oluvunyiweyo.Kwixesha elidlulileyo, unyango oluqhelekileyo olusekelwe kwiplatinam yechemotherapy doublet regimen lwaluthathwa njengonyango oluqhelekileyo lodidi lokuqala kuzo zonke izigulane ezine-NSCLC.Nangona kunjalo, ubungqina obuvelayo buchonge i-subpopulations apho unyango olujoliswe kuyo lusebenza ngakumbi, olukhokelela ekuphuhlisweni kwamachiza aguquguqukayo.I-Afatinib Dimaleate yaphuhliswa yi-Boehringer Ingelheim Pharmaceuticals, i-Afatinib Dimaleate yavunywa yi-FDA kwi-2013 njengeyeza lentandane phantsi kwegama lokuthengisa elithi Gilotrif.I-Afatinib Dimaleate yenziwe ngamachiza kusetyenziswa iindlela eziqhelekileyo.Afatinib Dimaleateayisebenzi kuphela ngokuchasene neenguqu ze-EGFR ezijoliswe kwisizukulwana sokuqala se-TKIs ezifana ne-erlotinib okanye i-gefitinib, kodwa kunye nokuguqulwa kwenguqu efana ne-T790M engakhathaliyo kolu nyango luqhelekileyo.Ngenxa yomsebenzi wayo owongezelelweyo ngokuchasene ne-Her2, iphandwa umhlaza wamabele kunye neminye imihlaza eqhutywa yi-EGFR kunye ne-Her2.
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Afatinib Dimaleate CAS 850140-73-7 Ubunyulu > 99.5...
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I-Afatinib CAS 439081-18-2 Ubunyulu > 99.5% (HPLC) F...
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(S)-(+)-3-Hydroxytetrahydrofuran CAS 86087-23-2...
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(Dimethylamino)acetaldehyde Diethyl Acetal CAS ...
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I-Diethylphosphonoacetic Acid CAS 3095-95-2 Purit...
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N-(3-Chloro-4-Fluorophenyl)-7-Fluoro-6-Nitroqui...
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Afatinib Dimaleate Intermediate CAS 314771-76-1...
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Afatinib Dimaleate Intermediate CAS 314771-88-5...
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7-Fluoro-6-Nitroquinazolin-4 (1H)-enye CAS 162012...
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I-7-Chloro-6-Nitro-4-Hydroxyquinazoline CAS 53449...
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Trans-4-Dimethylaminocrotonic Acid Hydrochlorid...