Afatinib Dimaleate CAS 850140-73-7 Ubunyulu > 99.5% (HPLC) API

Inkcazelo emfutshane:

Igama leKhemikhali: Afatinib Dimaleate

Izithethantonye: BIBW2992 Dimaleate

CAS: 850140-73-7

Ubunyulu: >99.0% (HPLC)

Imbonakalo: Mhlophe ukuya kwi-Off-White Powder

Umgangatho ophezulu we-API, iMveliso yoRhwebo

E-Mail: alvin@ruifuchem.com

Thumela i-imeyile kuthi

Iinkcukacha zeMveliso

Iimveliso ezinxulumeneyo

Iithegi zeMveliso

Inkcazo:

I-Ruifu Chemical Supply Intermediates ye-Afatinib
Afatinib CAS 439081-18-2
Afatinib Dimaleate CAS 850140-73-7
(S)-(+)-3-Hydroxytetrahydrofuran CAS 86087-23-2
(Dimethylamino)i-acetaldehyde I-Diethyl Acetal CAS 3616-56-6
trans-4-Dimethylaminocrotonic Acid Hydrochloride CAS 848133-35-7
I-Diethylphosphonoacetic Acid CAS 3095-95-2
7-Fluoro-6-Nitroquinazolin-4 (1H)-enye CAS 162012-69-3
I-7-Chloro-6-Nitro-4-Hydroxyquinazoline CAS 53449-14-2
N-(3-Chloro-4-Fluorophenyl)-7-Fluoro-6-Nitroquinazolin-4-Amine CAS 162012-67-1
(S)-N4-(3-Chloro-4-Fluorophenyl)-7-((Tetrahydrofuran-3-yl)oxy)quinazoline-4,6-DiamineI-CAS 314771-76-1
(S)-N-(3-Chloro-4-Fluorophenyl)-6-Nitro-7-((Tetrahydrofuran-3-yl)oxy)quinazolin-4-AmineI-CAS 314771-88-5

Iipropati zeMichiza:

Igama leMchiza	Afatinib Dimaleate
Izithethantonye	BIBW2992 Dimaleate;(S,E)-N-(4-(3-Chloro-4-Fluorophenylamino)-7-(Tetrahydrofuran-3-yloxy)quinazolin-6-yl)-4-(dimethylamino)kodwa-2-Enamide Dimaleate
Inombolo yeCAS	618-89-3
Inombolo yeCAT	RF-PI2032
Ubume beStokhwe	Kwi-Stock, iMveliso yoMveliso ukuya kwiiToni
Ifomula yeemolekyuli	I-C32H33ClFN5O11
Ubunzima beMolekyuli	718.08
Uvakalelo	Ukungenwa kukufuma
Uphawu	Ruifu Chemical

Iinkcukacha:

Into	Iinkcukacha
Imbonakalo	Mhlophe ukuya kwi-Off-White Powder
Ubunyulu / Indlela yokuHlalutya	>99.5% (HPLC)
Ilahleko ekomisweni	<0.50%
Intsalela kwi-Ignition	<0.10%
Ukungacoceki okuphezulu okukodwa	<0.30%
Ukungcola ngokupheleleyo	<0.50%
Iintsimbi ezinzima (njenge Pb)	≤20ppm
I-Infrared Spectrum	Iyahambelana neSakhiwo
NMR	Iyahambelana neSakhiwo
Umgangatho woVavanyo	Umgangatho woShishino
Beka ubomi kwishelufa	Iinyanga ezingama-24 ukuba zigcinwe ngokufanelekileyo
Ukusetyenziswa	API

Ukupakishwa kunye noGcino:

Iphakheji: Ibhotile, ingxowa yefoyile yeAluminiyam, 25kg/Igubu lekhadibhodi, okanye ngokwemfuno yomthengi

Imeko yoGcino:Gcina kwizikhongozeli ezivaliweyo kwindawo epholileyo neyomileyo;Khusela ukukhanya kunye nokufuma

Izinto eziluncedo:

FAQ:

Isicelo:

I-Afatinib Dimaleate (i-CAS: 850140-73-7), ifom ye-dimaleate yetyuwa ye-afanitib, i-agent ekhoyo yomlomo ye-antineoplastic.I-Afatinib Dimaleate yi-EGFR inhibitor ye-family inhibitor engenakuguqulwa kunye ne-IC50s ye-0.5 nM, 0.4 nM, 10 nM kunye ne-14 nM ye-EGFRwt, EGFRL858R, EGFRL858R/T790M kunye ne-HER2, ngokulandelanayo.I-Afatinib Dimaleate iboniswa kunyango lodidi lokuqala lwezigulane ezinomhlaza wemiphunga we-metastatic ongeyonxalenye encinci yeseli (NSCLC) enamathumba ane-epidermal growth factor receptor (EGFR) exon 19 deletions or exon 21 (L858R) substitution substitutions njengoko ifunyenwe yi-FDA- uvavanyo oluvunyiweyo.Kwixesha elidlulileyo, unyango oluqhelekileyo olusekelwe kwiplatinam yechemotherapy doublet regimen lwaluthathwa njengonyango oluqhelekileyo lodidi lokuqala kuzo zonke izigulane ezine-NSCLC.Nangona kunjalo, ubungqina obuvelayo buchonge i-subpopulations apho unyango olujoliswe kuyo lusebenza ngakumbi, olukhokelela ekuphuhlisweni kwamachiza aguquguqukayo.I-Afatinib Dimaleate yaphuhliswa yi-Boehringer Ingelheim Pharmaceuticals, i-Afatinib Dimaleate yavunywa yi-FDA kwi-2013 njengeyeza lentandane phantsi kwegama lokuthengisa elithi Gilotrif.I-Afatinib Dimaleate yenziwe ngamachiza kusetyenziswa iindlela eziqhelekileyo.Afatinib Dimaleateayisebenzi kuphela ngokuchasene neenguqu ze-EGFR ezijoliswe kwisizukulwana sokuqala se-TKIs ezifana ne-erlotinib okanye i-gefitinib, kodwa kunye nokuguqulwa kwenguqu efana ne-T790M engakhathaliyo kolu nyango luqhelekileyo.Ngenxa yomsebenzi wayo owongezelelweyo ngokuchasene ne-Her2, iphandwa umhlaza wamabele kunye neminye imihlaza eqhutywa yi-EGFR kunye ne-Her2.