Afatinib Dimaleate Intermediate CAS 314771-76-1 Ubunyulu > 99.0% (HPLC) Factory

Inkcazelo emfutshane:

Igama leMichiza: (S)-N4-(3-Chloro-4-Fluorophenyl)-7-((Tetrahydrofuran-3-yl)oxy)quinazoline-4,6-Diamine

CAS: 314771-76-1

Ubunyulu: >99.0% (HPLC)

Imbonakalo: Mthubi oKhanyayo ukuya kumgubo otyheli

Phakathi kwe-Afatinib Dimaleate (CAS: 850140-73-7)

E-Mail: alvin@ruifuchem.com

Thumela i-imeyile kuthi

Iinkcukacha zeMveliso

Iimveliso ezinxulumeneyo

Iithegi zeMveliso

Inkcazo:

I-Ruifu Chemical Supply Intermediates ye-Afatinib
Afatinib CAS 439081-18-2
Afatinib Dimaleate CAS 850140-73-7
(S)-(+)-3-Hydroxytetrahydrofuran CAS 86087-23-2
(Dimethylamino)i-acetaldehyde I-Diethyl Acetal CAS 3616-56-6
trans-4-Dimethylaminocrotonic Acid Hydrochloride CAS 848133-35-7
I-Diethylphosphonoacetic Acid CAS 3095-95-2
7-Fluoro-6-Nitroquinazolin-4 (1H)-enye CAS 162012-69-3
I-7-Chloro-6-Nitro-4-Hydroxyquinazoline CAS 53449-14-2
N-(3-Chloro-4-Fluorophenyl)-7-Fluoro-6-Nitroquinazolin-4-Amine CAS 162012-67-1
(S)-N4-(3-Chloro-4-Fluorophenyl)-7-((Tetrahydrofuran-3-yl)oxy)quinazoline-4,6-DiamineI-CAS 314771-76-1
(S)-N-(3-Chloro-4-Fluorophenyl)-6-Nitro-7-((Tetrahydrofuran-3-yl)oxy)quinazolin-4-AmineI-CAS 314771-88-5

Iipropati zeMichiza:

Igama leMchiza	(S)-N4-(3-Chloro-4-Fluorophenyl)-7-((Tetrahydrofuran-3-yl)oxy)quinazoline-4,6-Diamine
Izithethantonye	N4-(3-Chloro-4-Fluorophenyl) -7-[[(3S)-Tetrahydro-3-Furanyl]oxy] -4,6-Quinazolinediamine;Ukungacoceki kwe-Afatinib B;I-Afatinib-des(4-Dimethylamino-2-en-1-oxo)butyl;Des(4-Dimethylamino-2-en-1-oxo)butyl Afatinib
Inombolo yeCAS	314771-76-1
Inombolo yeCAT	RF-PI2028
Ubume beStokhwe	Kwi-Stock, iMveliso yeMveliso ye-100MT/Unyaka
Ifomula yeemolekyuli	I-C18H16ClFN4O2
Ubunzima beMolekyuli	374.8
Indawo yokubilisa	559.0±50.0℃
Ukuxinana	1.473±0.060 g/cm3
Uphawu	Ruifu Chemical

Iinkcukacha:

Into	Iinkcukacha
Imbonakalo	Umgubo oMthubi oKhanyayo ukuya kumthubi
Ukuchongwa	Ixesha lokuGcinwa kweNqununu kwi-HPLC kufuneka lihambelane noMgangatho
Ubunyulu / Indlela yokuHlalutya	>99.0% (HPLC)
Ilahleko ekomisweni	<0.50%
Intsalela kwi-Ignition	<0.20%
Ukungacoceki Okukodwa	<0.50%
Ukungcola ngokupheleleyo	<1.00%
Iintsimbi ezinzima (njenge Pb)	≤20ppm
Umgangatho woVavanyo	Umgangatho woShishino
Ukusetyenziswa	Phakathi kwe-Afatinib Dimaleate (CAS: 850140-73-7)

Ukupakishwa kunye noGcino:

Iphakheji: Ibhotile, ingxowa yefoyile yeAluminiyam, 25kg/Igubu lekhadibhodi, okanye ngokwemfuno yomthengi

Imeko yoGcino:Gcina kwizikhongozeli ezivaliweyo kwindawo epholileyo neyomileyo;Khusela ukukhanya kunye nokufuma

Izinto eziluncedo:

FAQ:

Isicelo:

(S)-N4- (3-Chloro-4-Fluorophenyl)-7-((Tetrahydrofuran-3-yl)oxy)quinazoline-4,6-Diamine (CAS: 314771-76-1) iphakathi kwe-Afatinib Dimaleate (CAS: 850140-73-7).I-Afatinib isizukulwana sesibini esinamandla kunye nesingenakuguquleka se-inhibitor ye-epidermal growth factor receptor (EGFR) kunye ne-epidermal growth factor receptor 2 (HER2) i-tyrosine kinase, ephuhliswe nguBoehringer Ingelheim, eJamani.Iyakwazi ukuvimbela ngokungenakuguqulwa umsebenzi we-tyrosine kinase ngokufumana impendulo kaMichael kunye neqela le-thiol le-cysteine kwindawo ye-797 ye-EGFR.Umsebenzi: 1. NjengeLapatinib kunye neNeratinib, i-Afatinib yi-protein kinase inhibitor ephinda ivimbele ngokungenakuphikiswa i-epidermal growth factor receptor 2 (Her2) kunye ne-epidermal growth factor receptor (EGFR) kinases.2. I-Afatinib ayisebenzi kuphela ngokumalunga nokuguqulwa kwe-EGFR ekujoliswe kuyo yi-TKI yesizukulwana sokuqala njenge-erlotinib okanye i-gefitinib, kodwa kunye nokuguqulwa kwenguqu efana ne-T790M engabalulekanga kula mayeza aqhelekileyo.Ngenxa yomsebenzi wayo owongezelelweyo ngokuchasene ne-Her2, iphandwa umhlaza wamabele kunye neminye imihlaza eqhutywa yi-EGFR kunye ne-Her2.3. I-Afatinib iyeza lonyango lokuqala lwezigulane ezineentlobo ezahlukeneyo ze-metastatic (EGFR mutation positive) engeyiyo encinci ye-cell lung carcinoma (NSCLC).Isebenza njenge-inhibitor ye-covalent engenakuguqulwa ye-receptor tyrosine kinases ye-epidermal growth factor receptor (EGFR) kunye ne-erbB-2 (HER2).