Afatinib Dimaleate Intermediate CAS 314771-88-5 Ubunyulu > 99.0% (HPLC) Factory

Inkcazelo emfutshane:

Igama leMichiza: (S)-N-(3-Chloro-4-Fluorophenyl)-6-Nitro-7-((Tetrahydrofuran-3-yl)oxy)quinazolin-4-Amine

CAS: 314771-88-5

Ubunyulu: >99.0% (HPLC)

Imbonakalo: Mthubi ukuya kwiPowder emthubi

Phakathi kwe-Afatinib Dimaleate (CAS: 850140-73-7)

E-Mail: alvin@ruifuchem.com

Thumela i-imeyile kuthi

Iinkcukacha zeMveliso

Iimveliso ezinxulumeneyo

Iithegi zeMveliso

Inkcazo:

I-Ruifu Chemical Supply Intermediates ye-Afatinib
Afatinib CAS 439081-18-2
Afatinib Dimaleate CAS 850140-73-7
(S)-(+)-3-Hydroxytetrahydrofuran CAS 86087-23-2
(Dimethylamino)i-acetaldehyde I-Diethyl Acetal CAS 3616-56-6
trans-4-Dimethylaminocrotonic Acid Hydrochloride CAS 848133-35-7
I-Diethylphosphonoacetic Acid CAS 3095-95-2
7-Fluoro-6-Nitroquinazolin-4 (1H)-enye CAS 162012-69-3
I-7-Chloro-6-Nitro-4-Hydroxyquinazoline CAS 53449-14-2
N-(3-Chloro-4-Fluorophenyl)-7-Fluoro-6-Nitroquinazolin-4-Amine CAS 162012-67-1
(S)-N4-(3-Chloro-4-Fluorophenyl)-7-((Tetrahydrofuran-3-yl)oxy)quinazoline-4,6-DiamineI-CAS 314771-76-1
(S)-N-(3-Chloro-4-Fluorophenyl)-6-Nitro-7-((Tetrahydrofuran-3-yl)oxy)quinazolin-4-AmineI-CAS 314771-88-5

Iipropati zeMichiza:

Igama leMchiza	(S)-N-(3-Chloro-4-Fluorophenyl)-6-Nitro-7-((Tetrahydrofuran-3-yl)oxy)quinazolin-4-Amine
Izithethantonye	N-(3-Chloro-4-Fluorophenyl)-6-Nitro-7-[(3S)-oxolan-3-yl]oxyquinazolin-4-Amine;7-((S)-Tetrahydrofuran-3-yloxy)-4-(3-Chloro-4-Fluorophenyl)amino-6-Nitroquinazoline;Afatinib Ukungcola
Inombolo yeCAS	314771-88-5
Inombolo yeCAT	RF-PI2027
Ubume beStokhwe	Kwi-Stock, iMveliso yoMveliso ukuya kwiiToni
Ifomula yeemolekyuli	I-C18H14ClFN4O4
Ubunzima beMolekyuli	404.78
Ukuxinana	1.534±0.060 g/cm3
Uphawu	Ruifu Chemical

Iinkcukacha:

Into	Iinkcukacha
Imbonakalo	Umgubo oMthubi ukuya kokuKhanya
Ubunyulu / Indlela yokuHlalutya	>99.0% (HPLC)
Ilahleko ekomisweni	<0.50%
Ukungacoceki komntu	<0.50%
Ukungcola ngokupheleleyo	<1.00%
Iintsimbi ezinzima	≤20ppm
Umgangatho woVavanyo	Umgangatho woShishino
Ukusetyenziswa	Phakathi kwe-Afatinib Dimaleate (CAS: 850140-73-7)

Ukupakishwa kunye noGcino:

Iphakheji: Ibhotile, ingxowa yefoyile yeAluminiyam, 25kg/Igubu lekhadibhodi, okanye ngokwemfuno yomthengi

Imeko yoGcino:Gcina kwizikhongozeli ezivaliweyo kwindawo epholileyo neyomileyo;Khusela ukukhanya kunye nokufuma

Izinto eziluncedo:

FAQ:

Isicelo:

(S)-N-(3-Chloro-4-Fluorophenyl)-6-Nitro-7-((Tetrahydrofuran-3-yl)oxy)quinazolin-4-Amine (CAS: 314771-88-5) isetyenziswa kwi ukulungiswa kwe-Afatinib Dimaleate (CAS: 850140-73-7).I-Afatinib lichiza ekujoliswe kulo elichasene nomhlaza, isizukulwana esitsha sechiza ekujoliswe kulo ngomlomo, iyeza lokuqala lehlabathi elichasene nomhlaza elibophelela ngokungenakuguquleka kusapho lwe-ErbB, kwaye lisebenza ngakumbi kwaye lijolise kwiiBlocks uphawu olubangela ukukhula kweeseli zomhlaza. , ukunciphisa okanye ukulibazisa ukwanda kweeseli zomhlaza.I-Afatinib yeyeklasi yamachiza eyaziwa ngokuba yi-tyrosine kinase inhibitors.Isebenza ngokuthintela umsebenzi weeprotheni ezimbini ezinxulumene ngokusondeleyo, i-epidermal growth factor receptor (EGFR) kunye ne-epidermal growth factor receptor 2 (HER2).Isetyenziselwa unyango lodidi lokuqala lwezigulane ezinomhlaza wemiphunga we-metastatic ongeyonxalenye encinci.I-Afatinib lichiza ekujoliswe kulo elichasene nomhlaza, isizukulwana esitsha sechiza ekujoliswe kulo ngomlomo, iyeza lokuqala lehlabathi elichasene nomhlaza elibophelela ngokungenakuguquleka kusapho lwe-ErbB, kwaye lisebenza ngakumbi kwaye lijolise kwiiBlocks uphawu olubangela ukukhula kweeseli zomhlaza. , ukunciphisa okanye ukulibazisa ukwanda kweeseli zomhlaza.