Apixaban CAS 503612-47-3 Ubunyulu ≥99.5% (HPLC)
I-Shanghai Ruifu Chemical Co., Ltd. ngumenzi ohamba phambili we-Apixaban (CAS: 503612-47-3) enomgangatho ophezulu.I-Ruifu Chemical inokubonelela ngenkonzo yehlabathi jikelele, ixabiso elikhuphisanayo, inkonzo egqwesileyo, encinci kunye nezixa ezininzi ezikhoyo.Thenga i-Apixaban,Please contact: alvin@ruifuchem.com
| Igama leMchiza | Apixaban |
| Izithethantonye | 1-(4-Methoxyphenyl) -7-oxo-6-[4-(2-oxopiperidin-1-yl)phenyl]-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine -3-carboxamide, 4,5,6,7-Tetrahydro-1- (4-methoxyphenyl) -7-oxo-6-[4-(2-oxo-1-piperidinyl) phenyl] -1H-pyrazolo[3, 4-c]pyridine-3-carboxamide, BMS 562247, BMS-562247 |
| Ubume beStokhwe | Kwi-Stock, iMveliso yoRhwebo |
| Inombolo yeCAS | 503612-47-3 |
| Ifomula yeemolekyuli | I-C25H25N5O4 |
| Ubunzima beMolekyuli | 459.51 g/mol |
| Indawo yokunyibilika | 235.0 ~ 238.0℃ |
| Ukuxinana | 1.42 |
| I-COA kunye ne-MSDS | Iyafumaneka |
| Imvelaphi | Shanghai, China |
| Udidi | API |
| Uphawu | Ruifu Chemical |
| Izinto | ImiGangatho yokuHlola | Iziphumo |
| Imbonakalo | Mhlophe ukuya kuMhlophe oMhlophe wePowder | Iyahambelana |
| Ilahleko ekomisweni | ≤0.50% | 0.10% |
| Intsalela kwi-Ignition | ≤0.10% | 0.08% |
| Iintsimbi ezinzima (njenge Pb) | ≤20ppm | Iyahambelana |
| Izinto ezinxulumeneyo | ||
| Nakuphi na Ukungacoceki Okukodwa | ≤0.50% | Iyahambelana |
| Ukungcola ngokupheleleyo | ≤0.50% | Iyahambelana |
| Ubunyulu / Indlela yokuHlalutya | ≥99.5% (HPLC) | 99.9% |
| I-Infrared Spectrum | Iyahambelana neSakhiwo | Iyahambelana |
| I-1 H NMR Spectrum | Iyahambelana neSakhiwo | Iyahambelana |
| Ukuqukumbela | Imveliso ivavanyiwe kwaye iyahambelana neenkcukacha | |
Umqulu:Ibhotile, ingxowa yefoyile yeAluminiyam, 25kg/Igubu lekhadibhodi, okanye ngokwemfuno yomthengi.
Imeko yoGcino:Gcina isikhongozeli sivalwe ngokuqinileyo kwaye usigcine kwindawo epholileyo, eyomileyo (2~8℃) kunye nendawo yokugcina impahla engena moya ikude kwizinto ezingahambelaniyo.Khusela ukukhanya kunye nokufuma.
Ukuhambisa ngenqanawe:Zisa kwihlabathi liphela ngomoya, ngeFedEx / DHL Express.Ukubonelela ngokukhawuleza nangokuthembekileyo.
Akukho nanye kwimveliso eya kubonelelwa kumazwe apho oku kunokungqubana namalungelo abenzi akhoyo.Nangona kunjalo uxanduva lokugqibela luxhomekeke kumthengi.
Ukusetyenziswa kophando lwezenzululwazi kuphela, hayi nayiphi na injongo yorhwebo, hayi ukusetyenziswa komntu okanye uxilongo.
Ukuthenga njani?Nceda uqhagamshelaneDr. Alvin Huang: sales@ruifuchem.com or alvin@ruifuchem.com
Amava Eminyaka Eli-15?Sineminyaka engaphezu kwe-15 yamava ekwenziweni nasekuthumeleni kumazwe angaphandle uluhlu olubanzi oluphezulu lwamayeza aphakathi okanye amachiza alungileyo.
Iimarike eziphambili?Thengisa kwimarike yasekhaya, eMntla Melika, eYurophu, eIndiya, eKorea, eJapan, eOstreliya, njl.
Iingenelo?Umgangatho ophezulu, ixabiso elifikelelekayo, iinkonzo zengcali kunye nenkxaso yobugcisa, ukuhanjiswa ngokukhawuleza.
UmgangathoIsiqinisekiso?Inkqubo yokulawula umgangatho ongqongqo.Izixhobo zobuchwephesha zokuhlalutya ziquka i-NMR, LC-MS, GC, HPLC, ICP-MS, UV, IR, OR, KF, ROI, LOD, MP, Clarity, Solubility, Microbial limit test, njl.
Iisampulu?Uninzi lweemveliso zibonelela ngeesampulu zasimahla zokuvavanya umgangatho, iindleko zokuthumela kufuneka zihlawulwe ngabathengi.
Factory Audit?Uphicotho-zincwadi lwasefektri wamkelekile.Nceda wenze idinga kwangaphambili.
MOQ?Akukho MOQ.Umyalelo omncinci wamkelekile.
Ixesha lokuzisa? Ukuba ngaphakathi kwesitokhwe, ukuhanjiswa kweentsuku ezintathu kuqinisekisiwe.
Ezothutho?Nge-Express (FedEx, DHL), ngoMoya, ngoLwandle.
Amaxwebhu?Emva kwenkonzo yokuthengisa: I-COA, i-MOA, i-ROS, i-MSDS, njl.
Udibaniso lweSiko?Inokubonelela ngeenkonzo zesiko lokudibanisa ukuze zilungele iimfuno zakho zophando.
Immimiselo yokuhlawula?I-invoyisi yeProforma iya kuthunyelwa kuqala emva kokuqinisekiswa kwe-odolo, efakwe kwiinkcukacha zethu zebhanki.Intlawulo nge-T / T (i-Telex Transfer), i-PayPal, i-Western Union, njl.
I-Apixaban (i-CAS: i-503612-47-3) yindlela entsha ye-anticoagulant yomlomo ephuhliswe nguBristol Myers Squibb kunye nePfizer.Luhlobo olutsha lwe-oral Xa factor inhibitor, kwaye igama layo lentengiso ngu-Eliquis.I-Apixaban isetyenziselwa ukunyanga izigulane ezikhulileyo ezithatha utyando olukhethiweyo lwe-hip okanye idolo ukukhusela i-venous thromboembolism (VTE)
I-Apixaban (i-CAS: 503612-47-3) i-oral selective activated Xa factor inhibitor kwaye inokuthintela ukuveliswa kwe-thrombin kunye ne-thrombosis.
I-Apixaban (i-CAS: i-503612-47-3) yinto yesithathu ye-anticoagulant yomlomo entsha eya kuthengiswa, ilandela i-dabigatran kunye ne-rivaroxaban, kwaye sele ivunyiwe eYurophu ukukhusela i-thromboembolism ye-venous kwizigulane ezithatha utyando olukhethiweyo lwe-hip okanye idolo.Kula ma-anticoagulants amathathu omlomo avunyiweyo eYurophu, xa kuthelekiswa nonyango lwangoku lothintelo oluchasene ne-venous thromboembolism, i-enoxaparin, i-rivaroxaban igqwesileyo kuvavanyo lwerekhodi, kwaye i-apixaban igqwesile kuvavanyo lwangaphambili.Iziphumo zokunyanga zeRivaroxaban zaziphezulu kancinci, kodwa zibangele ukopha kakhulu kune-apixaban.Abaphandi bathi ezi ntlukwano kwixesha leyeza, njengoko i-rivaroxaban ithathwe kwiiyure ze-6-8 emva kokuhlinzwa kwirekhodi yovavanyo, ngelixa i-apixaban isetyenziswe iiyure ze-18 emva kokuhlinzwa kwi-experiment yangaphambili.La machiza anesiphumo esingcono sokunyanga xa esetyenziswa kufutshane nexesha lotyando, kodwa abe nomngcipheko wokopha owandayo.Uphando lwezonyango lubonise ukuba xa kuthelekiswa ne-40mg ye-enoxaparin ye-subdermal yemihla ngemihla, i-2 oral 2.5mg dosages ye-apixaban yayinemiphumo engcono yokukhusela i-thromboembolism ye-venous elandela utyando lokutshintshwa kwe-hip okanye idolo kwaye ayizange inyuse ingozi yokopha.
I-Apixaban (i-CAS: 503612-47-3) luhlobo olutsha lwe-oral Xa factor inhibitor edibeneyo eyenziwe nguBristol-Myers Squibb kunye nePfizer.Igama lokurhweba yi-eratol, luhlobo olutsha lwe-anticoagulant yomlomo.Ngokuthintela i-coagulation factor Xa, i-apixaban inokuthintela ukuveliswa kwe-thrombin kunye ne-thrombosis.Ngo-Aprili 26, i-2007, i-Bristol-Myers Squibb yadibanisa izandla kunye noPfizer ukuvakalisa intsebenziswano ekuphuhliseni i-apixaban yomlomo ye-anticoagulant entsha ephethwe nguBristol-Myers Squibb njengenye indlela ephuculweyo ye-warfarin.Ngokwesivumelwano sentsebenziswano, uPfizer uya kuhlawula intlawulo yangaphambili ye-US $ 0.25 yezigidigidi kwi-Bristol-Myers Squibb ukuba ithwale i-60% yeendleko ezipheleleyo zophuhliso lwe-anticoagulant apixaban (iya kuphunyezwa ukususela ngoJanuwari 1, 2007), ngelixa iBristol-Myers. I-squibb iya kuthwala i-40% eseleyo, ngaloo ndlela ifumana ilungelo lokuphuhlisa ngokudibeneyo kunye nokuthengisa ichiza.NgoMeyi 2011, i-apixaban yaba ngowokuqala ukuvuma ukukhuselwa kwe-venous thrombosis kwizigulane zabantu abadala ezithatha utyando olukhethiweyo lwe-hip okanye idolo kumazwe angama-27 e-EU, e-Iceland naseNorway.NgoNovemba 20, i-2012, iKhomishoni yaseYurophu yavuma i-Ererto (i-apixaban) yokuthintela i-stroke kunye ne-systemic embolism kwizigulane zabantu abadala abane-non-valvular atrial fibrillation (NVAF) kunye neengozi enye okanye ngaphezulu.Emva koko, i-Canadian Food and Drug Administration, eJapan, kunye ne-US FDA yamvuma u-Ererto?(i-apixaban) yokukhusela i-stroke kunye ne-systemic embolism kwizigulane zabantu abadala abane-non-valvular atrial fibrillation (NVAF) kunye neengozi enye okanye ngaphezulu.Ngomhla we-12 ka-Apreli, i-2013, i-anticoagulant drug Eloto (ELIQUIS) (apixaban) ngokubambisana neBristol-Myers Squibb kunye nePfizer yabhengezwa ngokusemthethweni ukuba ibhalwe eChina.I-Ererto iyinoveli yomlomo we-Xa inhibitor yothintelo lwe-venous thromboembolism (VTE) kwizigulane zabantu abadala ezithatha indawo ekhethiweyo ye-hip okanye idolo.Uluhlu lwayo lunikeza ukhetho olutsha olukhuselekileyo nolusebenzayo lwe-anticoagulation yeklinikhi emva kotyando lwamathambo, kwaye izisa iindaba ezilungileyo kwizigulane zaseTshayina ezithatha indawo yokukhethwa kwe-hip / idolo.Izifundo zeklinikhi ziqinisekisile ukuba xa kuthelekiswa ne-40mg enoxaparin kanye ngosuku, amaxesha ama-2 ngosuku ulawulo lomlomo lwe-eratol?(i-apixaban) I-2.5mg isebenza ngakumbi ekukhuseleni i-thromboembolism ye-venous emva kokuhlinzwa kwe-hip okanye idolo, kwaye ayinyusi umngcipheko wokuphuma kwegazi.Umzobo we-1 ubonisa iipilisi ze-Elotoapixaban eziveliswe nguBristol-Myers Squibb kunye nePfizer.
![Apixaban Intermediate CAS 27143-07-3 Ethyl Chloro[(4-Methoxyphenyl)hydrazono]acetate Purity ≥99.0% (HPLC)](https://www.ruifuchemical.com/uploads/Apixaban-Intermediate-CAS-490-46-0-Factory-Shanghai-Ruifu-Chemical-Co.-Ltd.-www.ruifuchem.com_-300x300.jpg)
