Atazanavir CAS 198904-31-3 Purity ≥99.0% API Factory Anti-HIV-1 Protease Inhibitor
Ukubonelela ngoBusulungekileyo obuPhezulu kunye noMgangatho oZinzileyo
Igama leMichiza: Atazanavir
CAS: 198904-31-3
HIV-1 Protease Inhibitor
Umgangatho ophezulu we-API, iMveliso yoRhwebo
Igama leMchiza | Atazanavir |
Izithethantonye | BMS-232632 |
Inombolo yeCAS | 198904-31-3 |
Inombolo yeCAT | RF-API70 |
Ubume beStokhwe | Kwi-Stock, iMveliso yeMveliso ukuya kumakhulu eeKilogram |
Ifomula yeemolekyuli | I-C38H52N6O7 |
Ubunzima beMolekyuli | 704.86 |
Indawo yokunyibilika | 207.0 ~ 209.0℃ |
Ukunyibilika | Inyibilika kwi-DMSO;Ayinyibilikiyo emanzini |
Ugcino Lwexesha elide | Gcina Ixesha elide kwi -20 ℃ |
Uphawu | Ruifu Chemical |
Into | Iinkcukacha |
Imbonakalo | Umgubo oMhlophe |
Ifom | Isiseko sasimahla |
Ilahleko ekomisweni | ≤0.50% |
Intsalela kwi-Ignition | ≤0.20% |
Iintsimbi ezinzima | ≤20ppm |
Ukungcola A | ≤0.10% |
Ukungcola B | ≤0.10% |
Ukungacoceki Okukodwa | ≤0.20% |
Ukungcola ngokupheleleyo | ≤1.0% |
Indlela yokuhlanjululwa / yoHlalutya | ≥99.0% (HPLC) |
pH | 5.0~8.0 |
Umgangatho woVavanyo | Umgangatho woShishino |
Ukusetyenziswa | HIV-1 Protease Inhibitor Anti-HIV |
Iphakheji: Ibhotile, ingxowa yefoyile yeAluminiyam, Igubu lekhadibhodi, 25kg/Igubu, okanye ngokwemfuno yomthengi.
Imeko yoGcino:Gcina kwizikhongozeli ezivaliweyo kwindawo epholileyo neyomileyo;Khusela ekukhanyeni, ukufuma kunye nokuhlaselwa zizinambuzane.
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I-Atazanavir (CAS 198904-31-3) yi-antiretroviral, inoveli kunye neyeza elinamandla le-azapeptide yeklasi ye-protease inhibitor (PI).Ithengiswa phantsi kwegama lezorhwebo elithi Reyataz.Njengezinye ii-antiretrovirals, isetyenziselwa ukunyanga usulelo lwe-human immunodeficiency virus type 1 (HIV-1) protease enzyme kunye ne-inhibition constant Ki ye-66 nmol/L kwaye ikwathintela ukuphindaphindwa kwentsholongwane ye-HIV-1 kunye ne-50% yoxinaniso olusebenzayo EC50 ukusuka 2.6 ukuya ku-5.3 nmol/L.I-Atazanavir ibophelela kwi-HIV-1 protease inqanda ukuqhekeka kwe-gag kunye ne-gag-pol polyprotein, okukhokelela ekwenziweni kwee-virion ezingekavuthwa kwiiseli ezosulelwe yi-HIV-1.I-Atazanavir inokwakheka kweekhemikhali ezilinganayo ze-C-2 kunye namandla e-antiretroviral ngokubanzi kwiintlobo ezahlukeneyo ze-HIV xa kuthelekiswa nezinye ii-protease inhibitors, kubandakanywa i-Indinavir, i-Nelfinavir, i-Ritonavir, i-Saquinavir kunye ne-Amprenavir.I-Atazanavir yohlulwe kwezinye ii-PIs kuba inokunikwa kanye ngemini kwaye ineziphumo ezincinci kwiprofayili yelipid yesigulane.Njengezinye ii-protease inhibitors, isetyenziswa kuphela ngokudityaniswa namanye amayeza e-HIV.I-Atazanavir yinoveli ye-azapeptide HIV protease inhibitor.I-Antiviral.Ithathwa ngomlomo kanye ngosuku.
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