Atazanavir Sulfate CAS 229975-97-7 Purity ≥99.0% API Factory Anti-HIV-1 Protease Inhibitor
Ukubonelela ngoBusulungekileyo obuPhezulu kunye noMgangatho oZinzileyo
Igama leMichiza: Atazanavir Sulfate
I-CAS: 229975-97-7
HIV-1 Protease Inhibitor
Umgangatho ophezulu we-API, iMveliso yoRhwebo
Igama leMchiza | Atazanavir sulfate |
Izithethantonye | I-BMS-232632 Sulfate |
Inombolo yeCAS | 229975-97-7 |
Inombolo yeCAT | RF-API71 |
Ubume beStokhwe | Kwi-Stock, iMveliso yeMveliso ukuya kumakhulu eeKilogram |
Ifomula yeemolekyuli | C38H52N6O7.H2SO4 |
Ubunzima beMolekyuli | 802.93 |
Indawo yokunyibilika | 195.0 ~ 198.0℃ |
Ukunyibilika | Ayinyibiliki emanzini, iNyibilika kwi-DMSO |
Ugcino Lwexesha elide | Gcina Ixesha elide kwi -20 ℃ |
Uphawu | Ruifu Chemical |
Into | Iinkcukacha |
Imbonakalo | Umgubo oMhlophe okanye oMhlophe |
Sulfate | 12.0 ~ 12.5% |
Ilahleko ekomisweni | ≤0.50% |
Intsalela kwi-Ignition | ≤0.10% |
Iintsimbi ezinzima | ≤20ppm |
Ukungacoceki Okukodwa | ≤0.30% |
Ukungcola ngokupheleleyo | ≤1.0% |
Indlela yokuhlanjululwa / yoHlalutya | ≥99.0% (HPLC) |
pH | 5.0~8.0 |
Umgangatho woVavanyo | Umgangatho woShishino |
Ukusetyenziswa | HIV-1 Protease Inhibitor Anti-HIV |
Iphakheji: Ibhotile, ingxowa yefoyile yeAluminiyam, Igubu lekhadibhodi, 25kg/Igubu, okanye ngokwemfuno yomthengi.
Imeko yoGcino:Gcina kwizikhongozeli ezivaliweyo kwindawo epholileyo neyomileyo;Khusela ekukhanyeni, ukufuma kunye nokuhlaselwa zizinambuzane.
I-Atazanavir Sulfate (BMS-232632 Sulfate) (i-CAS: 229975-97-7) luhlobo lwetyuwa yesulfate ye-atazanavir ekhethwa kakhulu yi-HIV-1 protease inhibitor, yi-protease inhibitor yokuqala evunyiweyo ukuba ilawulwe kanye yonke imihla.I-Atazanavir Sulfate i-substrate kunye ne-inhibitor ye-CYP3A4, kunye ne-inhibitor kunye ne-inducer ye-P-glycoprotein (P-gp).I-Atazanavir Sulfate ikwayi-SARS-CoV 3CLpro inhibitor ene-IC50 ye-3.49 μM.I-Atazanavir Sulfate yi-azapeptide kunye ne-HIV-protease inhibitor esetyenziswa kunyango losulelo lwe-HIV kunye ne-AIDS ngokudibanisa nezinye ii-Anti-HIV Agents, iye yaphuhliswa kwaye yasungulwa yi-Bristol-Myers Squibb (BMS), phantsi kwelayisenisi yehlabathi evela kwi-Novartis, kunyango losulelo lwe-HIV.I-Atazanavir yasungulwa e-US njenge-Reyataz™ ngoJulayi 2003. I-Antiviral.I-Atazanavir ibonakalise ukuba namandla ngokubanzi kune-HIV-1 protease inhibitors ezivunyiweyo ngoku.I-Atazanavir inqanda ngokukhethekileyo ukusetyenzwa kwentsholongwane-ngqo kwintsholongwane yeGag kunye neGag-Pol polyprotein kwiiseli ezosulelekileyo ze-HIV-1 ngokuzibophelela kwindawo esebenzayo ye-HIV-1 protease, ngaloo ndlela ithintela ukwakheka kweeviriyoni ezivuthiweyo.I-Atazanavir ayisebenzi ngokuchasene ne-HIV-2.