Betamethasone CAS 378-44-9 Ubunyulu 97.0% ~ 103.0% API Factory High Purity High Featured Image

Betamethasone CAS 378-44-9 Purity 97.0%~103.0% API Factory High Purity

Inkcazelo emfutshane:

Igama leKhemikhali: Betamethasone

CAS: 378-44-9

Imbonakalo: Umgubo weCrystalline oMhlophe okanye ophantse wamhlophe

Ubunyulu: 97.0% ~ 103.0% yeC22H29FO5, kwisiseko esomileyo

Umgangatho ophezulu we-API, iMveliso yoRhwebo

Qhagamshelana: UGqr. Alvin Huang

Iselula/Wechat/WhatsApp: +86-15026746401

E-Mail: alvin@ruifuchem.com

Thumela i-imeyile kuthi

Iinkcukacha zeMveliso

Iimveliso ezinxulumeneyo

Iithegi zeMveliso

378-44-9 - Inkcazelo:

I-Betamethasone yezoRhwebo ngeNtengiso ephezulu kunye noMgangatho oZinzile
Igama leKhemikhali: Betamethasone
CAS: 378-44-9

378-44-9 -Iipropati zeMichiza:

Igama leMchiza	Betamethasone
Izithethantonye	Isiseko seBetamethasone;I-9alpha-Fluoro-16beta-Methylprednisolone;9-Fluoro-11,17,21-Trihydroxy-16-Methylpregna-1,4-Diene-3,20-Dione;(11beta,16alpha)-9-Fluoro-11,17,21-Trihydroxy-16-Methylpregna-1,4-Diene-3,20-Dione
Inombolo yeCAS	378-44-9
Ubume beStokhwe	Kwi-Stock, iMveliso yoMveliso ukuya kwiiToni
Ifomula yeemolekyuli	C22H29FO5
Ubunzima beMolekyuli	392.47
Indawo yokunyibilika	235.0~237.0℃
Imeko yokuthumela ngenqanawa	Phantsi koBubushushu be-Ambient
I-COA kunye ne-MSDS	Iyafumaneka
Uphawu	Ruifu Chemical

378-44-9 -Iinkcukacha:

Into	Iinkcukacha
Imbonakalo	Umgubo weCrystalline oMhlophe okanye ophantse wamhlophe
Isazisi A	Ukufunxwa kwe-infrared
Isazisi B	Uvavanyo lokuchongwa kweChromatographic eThin-Layer
Ujikelezo oluKhethekileyo lwe-Optical	+118.0 ° ukuya +126.0 ° (Ibalwe kwisiseko esomileyo)
Ukungacoceki komntu	≤1.00%
Ukungcola ngokupheleleyo	≤2.00%
Intsalela yezinyibilikisi zeMethanol	≤3000ppm
Intsalela yezinyibilikisi zeChloroform	≤60ppm
Ilahleko ekomisweni	≤0.50% (Yomise kwi-105 ℃, iiyure ze-3)
Intsalela kwi-Ignition	≤0.20%
Ubunyulu / Indlela yokuHlalutya	I-97.0% ~ 103.0% ye-C22H29FO5 Ibalwe kwisiseko esomileyo
Umgangatho woVavanyo	I-Pharmacopoeia yaseTshayina (CP);EP10.0 kunye ne-USP 42
Ukupakishwa kunye noGcino	Gcina kwizikhongozeli eziqinileyo.Gcina phakathi kwe-2℃ kunye ne-30℃.
Isicelo	I-Active Pharmaceutical ingredient (API)

Ukupakishwa kunye noGcino:

Umqulu:Ibhotile, ingxowa yefoyile yeAluminiyam, 25kg/Igubu lekhadibhodi, okanye ngokwemfuno yomthengi.
Imeko yoGcino:Gcina isikhongozeli sivalwe ngokuqinileyo kwaye usigcine kwindawo epholileyo, eyomileyo (2~30℃) kunye nendawo yokugcina impahla enomoya owaneleyo kude nezinto ezingahambelaniyo.Hlala kude nokukhanya okuqinileyo kunye nobushushu, ukufuma.
Ukuhambisa ngenqanawe:Zisa kwihlabathi liphela ngomoya, ngeFedEx / DHL Express.Ukubonelela ngokukhawuleza nangokuthembekileyo.

Izinto eziluncedo:

FAQ:

378-44-9 - Umngcipheko kunye noKhuseleko:

IiKhowudi zoMngcipheko R40 - Ubungqina obulinganiselweyo besiphumo se-carcinogenic
R48/20/21 -
I-R61 - Inokubangela ingozi kumntwana ongekazalwa
Inkcazelo yoKhuseleko S22 - Musa ukuphefumla uthuli.
S36 - Nxiba iimpahla ezifanelekileyo zokukhusela.
S45 - Kwimeko yengozi okanye ukuba uziva ungaphilanga, funa ingcebiso kagqirha ngokukhawuleza (bonisa ileyibhile nanini na kunokwenzeka.)
S53-Kuphephe ukuvezwa-fumana imiyalelo ekhethekileyo phambi kokusetyenziswa.
WGK eJamani 2
RTECS TU4000000
Ikhowudi yeHS 2937229000
Ubutyhefu LD50 ngomlomo kwimpuku: > 4500mg/kg

378-44-9 -Isicelo:

I-Betamethasone (i-CAS: i-378-44-9), i-adrenal corticosteroids, i-isomer ye-dexamethasone, kwaye indima ye-betamethasone ifana ne-prednisolone kunye ne-dexamethasone, ine-anti-inflammatory, anti-rheumatic, anti-allergic kunye nokunyanzeliswa. ye-immune kunye nezinye iziphumo ze-pharmacological, i-anti-inflammatory effect inamandla kune-dexamethasone, i-triamcinolone, i-hydrocortisone njl. ukusebenza ukudumba, anti-ukudumba isiphumo le mveliso 0.3mg ilingana dexamethasone 0.75mg, prednisone 5mg okanye 25mg cortisone.I-Betamethasone ye-sodium egcina isiphumo iphindaphindwe kalikhulu kune-hydrocortisone, kwi-hypofunction yokuqala ye-adrenal, inokusetyenziswa kunye ne-glucocorticoid kunyango lokutshintsha, kwaye isetyenziselwa ukuthintela okanye ukuthintela ukuphendula kwamajoni omzimba, ukulibazisa ukuchasana nomzimba kunye nokunciphisa amajoni omzimba. Ukwandiswa kwempendulo, isetyenziselwa i-renin ephantsi kunye ne-aldosterone syndrome ephantsi kunye ne-autonomic neuropathy eyenza i-orthostatic hypotension.Okwangoku, i-betamethasone ikwasetyenziselwa unyango lwe-rheumatoid arthritis, i-rheumatoid arthritis, i-lupus, i-asthma ye-bronchial, i-dermatitis enzima, i-leukemia ebukhali, i-atopic dermatitis, i-eczema, i-neurodermatitis, i-seborrheic dermatitis, kunye ne-pruritus kunye nonyango olubanzi losulelo oluthile.Imveliso iyachaswa kwimbali yengqondo enzima, isilonda se-duodenal esebenzayo, i-anastomosis yesisu samva nje, i-osteoporosis enzima, isifo seswekile esigqithisileyo, i-hypertension enzima, i-virus , i-bacterial, izifo zefungal ezisilelayo ukulawula ngokusetyenziswa kwe-antimicrobial agents , i-thrombophlebitis, izifo zesikhumba, ezifana njenge impetigo, tinea, jock itch njalo njalo.

378-44-9 - USP35 Standard:

Betamethasone
C22 H29FO5 392.46
Pregna-1,4-diene-3,20-dione, 9-fluoro-11,17,21-trihydroxy-16-methyl-, (11,16)-.
I-9-Fluoro-11,17,21-trihydroxy-16-methylpregna-1,4-diene-3,20-dione [378-44-9].
I-Betamethasone iqulethe ngaphantsi kweepesenti ze-97.0 kwaye ingabi ngaphezu kwe-103.0 ipesenti ye-C22H29FO5, ibalwa kwisiseko esomileyo.
Ukupakishwa kunye nokugcinwa-Londoloza kwizikhongozeli eziqinileyo.Gcina phakathi kwe-2℃ kunye ne-30℃.
Imigangatho yezalathiso ye-USP <11>-
USP Betamethasone RS
Isazisi-
A: I-Infrared Absorption <197M>.
B: Uvavanyo lokuchongwa kweChromatographic eThin-Layer <201>-
Isisombululo sovavanyo-Lungisa isisombululo seBetamethasone kwi-alcohol encitshisiweyo ene-0.5 mg nge-mL.
Ukuphuhlisa inkqubo ye-solvent: umxube we-chloroform kunye ne-diethylamine (2: 1).
Inkqubo-Qhubeka njengoko kuyalelwe kwisahluko, ngaphandle kokukhangela amabala ngokutshiza kancinci nge-dilute sulfuric acid (1 ku-2) kunye nokufudumeza kwipleyiti eshushu okanye phantsi kwesibane kude kuvele amabala.
Ukujikeleza okuthe ngqo <781S>: phakathi +118 kunye +126, kubalwe ngesiseko esomileyo.
Isisombululo sovavanyo: 5 mg nge-mL, kwi-methanol.
Ilahleko ekumiseni i-731-Yomise kwi-105 kwiiyure ze-3: ilahlekelwa ngaphezu kwe-1.0% yobunzima bayo.
Intsalela ekutshisweni kwe-281: hayi ngaphezulu kwe-0.2%, i-platinam crucible isetyenziswa.
Ukungcola okuqhelekileyo 466-
Isisombululo sovavanyo: methanol.
Isisombululo esisemgangathweni: i-methanol.
Umthamo wosetyenziso: 10 µL.
I-Eluant: umxube we-toluene, i-acetone, i-methyl ethyl ketone, kunye ne-asidi ye-formic (55: 20: 20: 5), kwigumbi elingenakulinganiswa.
Umbono: 5.
Isivavanyi-
Isigaba esiphathwayo-Lungisa umxube ohluziweyo kunye ne-degassed yamanzi kunye ne-acetonitrile (63:37).Yenza uhlengahlengiso xa kukho imfuneko (jonga ukufaneleka kweNkqubo phantsi kweChromatography 621).
Isisombululo somgangatho wangaphakathi-Lungisa isisombululo sepropylparaben etywaleni esinogxininiso olwaziwayo malunga ne-0.25 mg nge-mL.
Ukulungiswa okusemgangathweni-Dibanisa isixa esilinganiswe ngokuchanekileyo se-USP Betamethasone RS etywaleni ukuze ufumane isisombululo esinoxinzelelo olwaziwayo malunga ne-0.2 mg nge-mL nganye.Dlulisa i-10.0 mL yesi sisombululo kwi-vial efanelekileyo, kwaye ungeze i-10.0 mL yesisombululo esisemgangathweni sangaphakathi, ukufumana ukulungiswa koMgangatho onolwazi malunga ne-0.1 mg ye-betamethasone kunye ne-0.125 mg yepropylparaben nge-mL.
Ukulungiswa kwe-Assay-Ukusebenzisa malunga ne-80 mg ye-Betamethasone, ilinganiswe ngokuchanekileyo, lungiselela njengoko kulungiselelwe ukulungiswa okuPhakathi.
Inkqubo yeChromatographic (jonga i-Chromatography 621) -I-chromatograph yolwelo ixhotyiswe nge-240-nm detector kunye nekholamu ye-4.6-mm × 25-cm equlethe ukupakisha i-L1.Izinga lokuhamba malunga ne-1.0 mL ngomzuzu.I-Chromatograph Ukulungiswa koMgangatho, kwaye urekhode iimpendulo eziphezulu njengoko ziqondiswe kwiNkqubo: amaxesha okugcinwa okuhambelanayo malunga ne-1.0 ye-betamethasone kunye ne-1.4 yepropylparaben;isisombululo, R, phakathi kwe-betamethasone kunye nepropylparaben ayikho ngaphantsi kwe-3.0;kunye nokutenxa komgangatho ozalanayo wokuphindaphinda iinaliti akukho ngaphezu kwe-2.0%.
Inkqubo-Ngokwahlukileyo tofa imithamo elinganayo (malunga ne-10 µL) yolungiselelo loMgangatho kunye nolungiselelo loVavanyo kwichromatograph, urekhode iichromatograms, kwaye ulinganise iimpendulo zeencopho ezinkulu.Bala ubungakanani, kwi-mg, ye-C22H29FO5 kwinxalenye yeBetamethasone ethathwe ngefomula:
800C(RU / RS)
apho i-C igxininise, kwi-mg nge-mL, ye-USP ye-Betamethasone RS kulungiselelo oluMgangatho;kunye ne-RU kunye ne-RS yimilinganiselo yokuphakama kwencopho ye-betamethasone peak kunye nencopho yomgangatho wangaphakathi efunyenwe kulungiselelo lwe-Assay kunye nokulungiswa koMgangatho, ngokulandelanayo.