I-Boc-(R)-3-Amino-4-(2,4,5-Trifluoro-Phenyl)-Butyric Acid CAS 486460-00-8 Ubunyulu ≥99.5% (HPLC) I-Sitagliptin Phosphate Monohydrate ePhakathi Umfanekiso oMphakathi

Boc-(R)-3-Amino-4-(2,4,5-Trifluoro-Phenyl)-Butyric Acid CAS 486460-00-8 Ubunyulu ≥99.5% (HPLC) Sitagliptin Phosphate Monohydrate Intermediate

Inkcazelo emfutshane:

I-Boc-(R)-3-Amino-4-(2,4,5-Trifluoro-Phenyl)-Butyric Acid

CAS: 486460-00-8

Ubunyulu: ≥99.5% (HPLC)

Imbonakalo: Mhlophe ukuya kwi-Off-White Powder

I-Intermediate ye-Sitagliptin Phosphate Monohydrate (CAS: 654671-77-9) yonyango lwe-II diabetes mellitus

Umgangatho ophezulu, iMveliso yoRhwebo

E-Mail: alvin@ruifuchem.com

Thumela i-imeyile kuthi

Iinkcukacha zeMveliso

Iimveliso ezinxulumeneyo

Iithegi zeMveliso

Inkcazo:

Ubonelelo ngeSitagliptin Phosphate Monohydrate Eziyeleleneyo neziPhakathi:
I-Sitagliptin API CAS 486460-32-6
I-Sitagliptin Phosphate Monohydrate API CAS 654671-77-9
2,4,5-Trifluorophenylacetic Acid CAS 209995-38-0
Boc-(R)-3-Amino-4-(2,4,5-Trifluoro-Phenyl)-Butyric Acid CAS 486460-00-8
I-Sitagliptin Triazole Hydrochloride CAS 762240-92-6
I-Sitagliptin Phosphate Monohydrate ePhakathi CAS 486460-21-3

Iipropati zeMichiza:

Igama leMchiza	I-Boc-(R)-3-Amino-4-(2,4,5-Trifluoro-Phenyl)-Butyric Acid
Izithethantonye	(R)-Sitagliptin N-Boc-Acid Ukungcola
Inombolo yeCAS	486460-00-8
Inombolo yeCAT	RF-PI1192
Ubume beStokhwe	Kwi-Stock, iMveliso yoMveliso ukuya kwiiToni
Ifomula yeemolekyuli	C15H18F3NO4
Ubunzima beMolekyuli	333.31
Indawo yokunyibilika	136.0 ~ 138.0℃
Uphawu	Ruifu Chemical

Iinkcukacha:

Into	Iinkcukacha
Imbonakalo	Mhlophe ukuya kwi-Off-White Powder
Ukuchongwa yi-HPLC	Ixesha lokuGcinwa kweSampuli lihambelana noMgangatho weReferensi
Ilahleko ekomisweni	≤0.50%
Uthuthu lweSulfate	≤0.50%
Iintsimbi ezinzima	<20ppm
Isomer	≤0.50%
Izinto ezinxulumeneyo
Ukungcola A	≤0.50%
Nakuphi na Okunye Ukungcola Okukodwa	≤0.50%
Ukungcola ngokupheleleyo	≤0.50%
Ubunyulu	≥99.5% (HPLC)
Umgangatho woVavanyo	Umgangatho woShishino
Ukusetyenziswa	Umbindi weSitagliptin Phosphate Monohydrate (CAS: 654671-77-9)

Ukupakishwa kunye noGcino:

Iphakheji: Ibhotile, ingxowa yefoyile yeAluminiyam, 25kg/Igubu lekhadibhodi, okanye ngokwemfuno yomthengi.

Imeko yoGcino:Gcina kwizikhongozeli ezivaliweyo kwindawo epholileyo neyomileyo;Khusela ukukhanya kunye nokufuma.

Izinto eziluncedo:

FAQ:

Isicelo:

I-Boc-(R)-3-Amino-4- (2,4,5-Trifluoro-Phenyl)-I-Butyric Acid (i-CAS: 486460-00-8) yinto ebalulekileyo ephakathi ukulungiselela i-sitagliptin.I-Sitagliptinphosphate yi-inhibitor yokuqala ye-dipeptidase -IV (DPP-4) evunywe yi-FDA ngo-2006. Isetyenziselwa unyango lwe-type II diabetes mellitus.Inesiphumo esicacileyo se-hypoglycemic xa isetyenziswa yodwa okanye idityaniswe ne-metformin kunye ne-pioglitazone, kwaye kukhuselekile ukuyithatha, inyamezeleke kakuhle, kunye neempendulo ezimbalwa ezibi.Ngo-Agasti ka-2009, ichiza lamkelwa yiManyano yaseYurophu njengechiza lokuqala kunyango lwe-2 seswekile.Emva kwe-2011, elinye emva kwelinye ilizwe livumile ukudibanisa i-sitagliptin phosphate kunye ne-alpha glycosidase inhibitors okanye i-insulin.I-Sitagliptin phosphate yeyokuqala i-FDA-evunyiweyo yi-dipeptidyl peptidase-IV inhibitor ukuba isetyenziswe kunyango lwe-2 yeswekile ukuza kuthi ga ngoku, phantsi kwegama lorhwebo i-Januvia.