Brexpiprazole CAS 913611-97-9 Ubunyulu > 99.0% (HPLC) API Factory
Ruifu Chemical Supply Brexpiprazole Intermediates
Brexpiprazole CAS 913611-97-9
7-Hydroxyquinolinone CAS 70500-72-0
4-Bromobenzo[b]thiophene CAS 5118-13-8
1-(1-Benzothiophen-4-yl)piperazine Hydrochloride CAS 913614-18-3
7-(4-Chlorobutoxy)quinolin-2(1H)-enye CAS 913613-82-8
4-Chlorobenzo[b]thiophene CAS 66490-33-3
Igama leMchiza | Brexpiprazole |
Izithethantonye | OPC-34712;7-(4-(4-(Benzo[b]thiophen-4-yl)piperazin-1-yl)butoxy)quinolin-2(1H)-enye |
Inombolo yeCAS | 913611-97-9 |
Inombolo yeCAT | RF-PI1982 |
Ubume beStokhwe | Kwi-Stock, iMveliso yoMveliso ukuya kwiiToni |
Ifomula yeemolekyuli | I-C25H27N3O2S |
Ubunzima beMolekyuli | 433.57 |
Ukuxinana | 1.245±0.060 g/cm3 |
Uphawu | Ruifu Chemical |
Into | Iinkcukacha |
Imbonakalo | Umgubo weCrystalline oMhlophe okanye oMhlophe |
Ukuchongwa | Ngu-IR |
RT | Ngaphantsi kwe-chirality kufuneka ihambelane |
I-Chloride | Inika ukusabela kwekloridi |
Amanzi | 3.0%~4.5% |
Indawo yokunyibilika | 198.0 ~ 202.0℃ |
Intsalela kwi-Ignition | <0.20% |
Iintsimbi ezinzima | ≤10ppm |
Izinto ezinxulumeneyo | |
Ukungacoceki komntu | <0.50% |
Ukungcola ngokupheleleyo | <1.00% |
EE | >99.0% |
Ubunyulu / Indlela yokuHlalutya | >99.0% (HPLC, ngokomileyo) |
Umgangatho woVavanyo | Umgangatho woShishino |
Ukusetyenziswa | API |
Iphakheji: Ibhotile, ingxowa yefoyile yeAluminiyam, 25kg/Igubu lekhadibhodi, okanye ngokwemfuno yomthengi
Imeko yoGcino:Gcina kwizikhongozeli ezivaliweyo kwindawo epholileyo neyomileyo;Khusela ukukhanya kunye nokufuma
I-Brexpiprazole (i-CAS: i-913611-97-9) ngumviwa weziyobisi oluncedo kunyango kunye nokuthintela ukuphazamiseka kwengqondo kuquka ukuphazamiseka kwe-CNS.I-Brexpiprazole lichiza eliyinoveli le-antipsychotic elisebenza njenge-serotonin ® dopamine umsebenzi wemodyuli kwaye ibonise ukusebenza njengonyango lokongezelela kwizigulana ezinoxinzelelo olukhulu loxinzelelo (MDD).I-Brexpiprazole ibonisa iphrofayili ekhethekileyo ye-pharmacological, esebenza njenge-agonist inxalenye ye-serotonin 5-HT1A kunye ne-dopamine D2 receptors kunye nomchasi opheleleyo we-5-HT2A kunye ne-noradrenaline α1B / 2C i-receptors, kunye ne-subnanomolar efanayo ebophelelayo.I-Brexpiprazole yaphuhliswa ngu-Otsuka kunye no-Lundbeck, yavunywa kwi-2015 yi-FDA yonyango lwe-schizophrenia kunye nonyango olongezelelweyo lokudakumba.I-Brexpiprazole ithathwa ngokubanzi njengendlalifa ye-Otsuka ye-antipsychotic drug aripiprazole (igama lorhwebo i-Abilify) eliphelelwe ilungelo labo lomenzi ngo-Agasti ka-2014.