Brigatinib CAS 1197953-54-0 Ubunyulu > 99.0% (HPLC)

Inkcazelo emfutshane:

Igama leKhemikhali: Brigatinib

Izithethantonye: AP-26113

CAS: 1197953-54-0

Ubunyulu: >99.0% (HPLC)

Imbonakalo: Mhlophe ukuya kwi-Off-White Powder

Qhagamshelana: UGqr. Alvin Huang

Iselula/Wechat/WhatsApp: +86-15026746401

E-Mail: alvin@ruifuchem.com

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1197953-54-0 -Inkcazo:

I-Shanghai Ruifu Chemical Co., Ltd. ngumenzi ohamba phambili weBrigatinib (AP-26113) (i-CAS: 1197953-54-0) enomgangatho ophezulu.I-Ruifu Chemical inokubonelela ngenkonzo yehlabathi jikelele, ixabiso elikhuphisanayo, inkonzo egqwesileyo, encinci kunye nezixa ezininzi ezikhoyo.Thenga iBrigatinib,Please contact: alvin@ruifuchem.com

1197953-54-0 -Iipropati zeMichiza:

Igama leMchiza	Brigatinib
Izithethantonye	AP26113;AP-26113;5-Chloro-N4-[2-(Dimethylphosphinyl)phenyl]-N2-[2-Methoxy-4-[4-(4-Methyl-1-Piperazinyl)-1-Piperidinyl]phenyl]-2,4-Pyrimidinediamine
Ubume beStokhwe	Kwi-Stock, iMveliso yoRhwebo
Inombolo yeCAS	1197953-54-0
Ifomula yeemolekyuli	I-C29H39ClN7O2P
Ubunzima beMolekyuli	584.09 g/mol
Indawo yokunyibilika	>203℃(ngoDisemba)
Ukuxinana	1.31±0.10 g/cm3
I-COA kunye ne-MSDS	Iyafumaneka
Imvelaphi	Shanghai, China
Uphawu	Ruifu Chemical

1197953-54-0 -Iinkcukacha:

Izinto	Iinkcukacha	Iziphumo
Imbonakalo	Mhlophe ukuya kwi-Off-White Powder	Iyahambelana
Ubunyulu / Indlela yokuHlalutya	>99.0% (HPLC)	99.26%
Max.Ukungacoceki Okukodwa	<1.00%	0.25%
Ilahleko ekomisweni	<1.00%	0.27%
I-Infrared Spectrum	Ngokungqinelana noLwakhiwo	Iyahambelana
I-1H NMR Spectrum	Ngokungqinelana noLwakhiwo	Iyahambelana
Ukuqukumbela	Imveliso ivavanyiwe kwaye ihambelana neenkcukacha ezinikiweyo

Ukupakishwa/uGcino/Ukuhambisa ngenqanawe:

Umqulu:Ibhotile eFluorinated, iAluminium foil bag, 25kg/Cardboard Drum, okanye ngokwemfuno yomthengi.
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Umgangatho ophezulu: Kusekwe inkqubo epheleleyo yokuqinisekisa umgangatho

FAQ:

Ukuthenga njani?Nceda uqhagamshelaneDr. Alvin Huang: sales@ruifuchem.com or alvin@ruifuchem.com

Amava Eminyaka Eli-15?Sineminyaka engaphezu kwe-15 yamava ekwenziweni nasekuthumeleni kumazwe angaphandle uluhlu olubanzi oluphezulu lwamayeza aphakathi okanye amachiza alungileyo.

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Amaxwebhu?Emva kwenkonzo yokuthengisa: I-COA, i-MOA, i-ROS, i-MSDS, njl.

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1197953-54-0 - Inkcazo ngokubanzi:

I-Brigatinib (AP-26113) (i-CAS: 1197953-54-0) luphando oluncinci lwe-molecule ejoliswe kunyango lomhlaza oluphuhliswa yi-ARIAD Pharmaceuticals, Inc. Brigatinib liyeza elisetyenziselwa ukunyanga umhlaza ocinezela i-epidermal growth factor receptor (EGFR) kunye i-anaplastic lymphoma kinase (ALK).I-Brigatinib i-agonist ekhethiweyo ngokuchasene nokuhluka kwe-EGFR ngokuchasene neefom ze-mutant zasendle.Ichiza likwabonisa ukukhetha ngokuchasene nejini ye-ALK-EML4 yokudibanisa, eyona mba isisiseko sohlengahlengiso lwe-lung parenchyma.I-Brigatinib imiselwe izigulane ezineejeni ezithile ezingaqhelekanga kwaye xa umhlaza wemiphunga ye-cell (NSCLC) engeyiyo encinci ayiphenduli kulawulo kunye namanye amayeza.I-Brigatinib ihlelwa njenge-kinase inhibitor, indlela yokusebenza kwayo ibandakanya ukucinezela isenzo seeprotheyini ezingaqhelekanga ezandisa ukwanda kweeseli zomhlaza.

1197953-54-0 - Iimpawu:

I-Brigatinib (i-CAS: i-1197953-54-0) imiselwe izigulane ezineendlela ezithile ze-NSCLC eziye zasasazeka kumacandelo ahlukeneyo omzimba kubantu abaye bafumana unyango lwangaphambili kunye namanye amayeza omhlaza afana ne-Crizotinib, kwaye imeko yabo ibe yimbi ngakumbi. okanye zibonisa iimpawu ezincinci zokuphucuka.Ikakhulu iphantsi kophando ngonyango lwayo kumhlaza wemiphunga weseli ongeyiyo encinci (NSCLC) apho i-ALK iyasebenza kwaye iinguqu ze-EGFP zihlala zenzeka.

1197953-54-0 - Isicelo:

I-Brigatinib (AP-26113) (i-CAS: 1197953-54-0) yi-inhibitor yesizukulwana esitsha se-tyrosine kinase, ebonisa ukusebenza okubonakalayo kwi-ALK + ye-metastatic NSCLC.Ngomhla ka-Agasti 30, i-2016, i-United States FDA inike i-bugtinib njengonyango oluphumelelayo kunye neyeza elinqabileyo le-ALK + NSCLC kwizigulane eziye zaphuhliswa okanye azikwazi ukunyamezela i-Crizotinib, isizukulwana sokuqala sonyango lwe-ALK + NSCLC.Nika ingqwalaselo ephambili kuluhlu lokuphononongwa kwesicelo kwaye uvumele idatha yesicelo ukuba ingeniswe ngokuqhubekayo.I-FDA ivume i-Bugtinib ngo-Ephreli 28, i-2017, phantsi kwegama lezorhwebo elithi Alunbrigtm.