Candesartan Cilexetil CAS 145040-37-5 Ubunyulu > 99.0% (HPLC) API Factory

Inkcazelo emfutshane:

Igama leMichiza: Candesartan Cilexetil

CAS: 145040-37-5

Ubunyulu: >99.0% (HPLC)

Imbonakalo: Mhlophe ukuya kuMhlophe-Mhlophe wePowder

Umchasi we-Angiotensin II okhethiweyo

Umgangatho ophezulu we-API, iMveliso yoRhwebo

E-Mail: alvin@ruifuchem.com

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Iinkcukacha zeMveliso

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Iithegi zeMveliso

Inkcazo:

Ubonelelo lweMichiza yeRuifu Candesartan Cilexetil ePhakathi ngokucoceka okuphezulu
Candesartan Cilexetil CAS 145040-37-5
Candesartan CAS 139481-59-7
I-1-Chloroethyl Cyclohexyl Carbonate CAS 99464-83-2
Candesartan Cilexetil Phakathi Eethyl Ester C6 CAS 139481-41-7
Candesartan Cilexetil Intermediate CAS 139481-44-0
I-Trityl Candesartan Cilexetil CAS 170791-09-0

Iipropati zeMichiza:

Igama leMchiza	Candesartan Cilexetil
Izithethantonye	I-TCV-116;1-(((Cyclohexyloxy)carbonyl)oxy)ethyl 1-((2'-(1H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)methyl)-2-ethoxy-1H -benzo[d] imidazole-7-Carboxylate
Inombolo yeCAS	145040-37-5
Inombolo yeCAT	RF-PI1891
Ubume beStokhwe	Kwi-Stock, iMveliso yoMveliso ukuya kwiiToni
Ifomula yeemolekyuli	I-C33H34N6O6
Ubunzima beMolekyuli	610.66
Uphawu	Ruifu Chemical

Iinkcukacha:

Into	Iinkcukacha
Imbonakalo	Mhlophe ukuya kuMhlophe oMhlophe wePowder
Ukuchongwa kwe-HPLC	Ixesha lokugcinwa kwencopho enkulu kwikhromatogram yesampulu ihambelana naleyo ikwichromatogram efunyenwe ngomgangatho
Ukuchongwa kwe-IR	I-IR infrared absorption spectrum iyafana naleyo yeCandesartan Cilexetil yereferensi yomgangatho
Ukucaca kunye nesisombululo soMbala	Isisombululo kwi-chloroform kwi-5% icacile kwaye ayinambala
Ubunyulu / Indlela yokuHlalutya	>99.0% (HPLC)
Indawo yokunyibilika	155.0 ~ 160.0℃
Ilahleko ekomisweni	<0.30%
Intsalela kwi-Ignition	<0.10%
Iintsimbi ezinzima	<10ppm
IArsenic (As)	<1ppm
Ukuhanjiswa kobungakanani beNcam	90% <30 μm
Ukungcola Okuphilayo	nguHPLC
Ethyl Candesartan	<0.15%
Desethyl Candesartan	<0.15%
N2-Ethyl Candesartan Cilexei	<0.15%
Nakuphi na Ukungcola Okungaziwa	<0.15%
Ukungcola ngokupheleleyo	<0.60%
Uvavanyo lwePotentiometry	I-99.0 ~ 101.0% ye-C33H34N6O6, ibalwa kwizinto ezingenamanzi
Ukungacoceki okuguquguqukayo kwe-Organic
Methano	<0.30%
I-Ethanol	<0.50%
I-Diethyl Ether	<0.50%
IAceton	<0.50%
IDichloromethan	<0.06%
I-Dimethylformamide	<0.088%
Ungcoliseko lweMicrobiological
Ubalo olupheleleyo lweAerobic Microbial	<1000cfu/g
Umngundo kunye negwele	<100cfu/g
E.Coli	Ukungabikho
Salmonella	Ukungabikho
Umgangatho woVavanyo	Umgangatho woShishino
Ukusetyenziswa	API;Iarhente yeAntihypertensive

Ukupakishwa kunye noGcino:

Iphakheji: Ibhotile, ingxowa yefoyile yeAluminiyam, 25kg/Igubu lekhadibhodi, okanye ngokwemfuno yomthengi

Imeko yoGcino:Gcina kwizikhongozeli ezivaliweyo kwindawo epholileyo neyomileyo;Khusela ukukhanya kunye nokufuma

Izinto eziluncedo:

FAQ:

Isicelo:

I-Candesartan Cilexetil (TCV-116) (i-CAS: 145040-37-5) i-angiotensin II receptor antagonist kunye ne-IC50 ye-0.26 nM, esetyenziselwa unyango lwe-hypertension.I-Candesartan yi-angiotensin-receptor blocker (ARB) enokuthi isetyenziswe yodwa okanye kunye nezinye ii-agent ukunyanga uxinzelelo lwegazi.Ilawulwa ngomlomo njenge-prodrug, i-candesartan cilexetil, eguqulelwa ngokukhawuleza kwi-metabolite esebenzayo, i-candesartan, ngexesha lokufunxa kwi-gastrointestinal tract.I-Candesartan yehlisa uxinzelelo lwegazi ngokuchasa inkqubo ye-renin-angiotensin-aldosterone (RAAS);ikhuphisana ne-angiotensin II ngokubophelela kuhlobo lwe-1 i-angiotensin II receptor (AT1) i-subtype kwaye inqande uxinzelelo lwegazi olukhulayo iziphumo ze-angiotensin II.Ngokungafaniyo ne-angiotensin-converting enzyme (ACE) inhibitors, ii-ARB azinayo impembelelo embi yokukhwehlela okomileyo.I-Candesartan ingasetyenziselwa ukunyanga uxinzelelo lwegazi oluphezulu, uxinzelelo lwegazi lwe-systolic olulodwa, i-hypertrophy ye-ventricular yasekhohlo kunye ne-nephropathy yesifo seswekile.Inokusetyenziswa njengenye indlela yonyango lokungaphumeleli kwentliziyo, ukungasebenzi kakuhle kwe-systolic, i-myocardial infarction kunye nesifo se-coronary artery.