I-Capecitabine CAS 154361-50-9 Ubunyulu 98.0% ~ 102.0% API Umgangatho ophezulu
Unikezelo lwezoRhwebo abaPhakathi abaNxulumeneyo neCapecitabine:
I-5-Fluorocytosine CAS: 2022-85-7
2',3'-Di-O-acetyl-5'-deoxy-5-fluorocytidine CAS: 161599-46-8
I-1,2,3-Tri-O-acetyl-5-deoxy-β-D-ribofuranose CAS: 62211-93-2
Capecitabine CAS: 154361-50-9
| Igama leMchiza | Capecitabine |
| Inombolo yeCAS | 154361-50-9 |
| Inombolo yeCAT | RF-API08 |
| Ubume beStokhwe | Kwi-Stock, iMveliso yoMveliso ukuya kwiiToni |
| Ifomula yeemolekyuli | I-C15H22FN3O6 |
| Ubunzima beMolekyuli | 359.35 |
| Indawo yokunyibilika | 110.0 ~ 121.0℃ |
| Imeko yokuthumela ngenqanawa | Phantsi koBubushushu be-Ambient |
| Uphawu | Ruifu Chemical |
| Into | Iinkcukacha |
| Imbonakalo | Umgubo oMhlophe |
| Ukuchongwa | Isampulu ye-IR Spectrum kufuneka ihambelane ne-spectrum yomgangatho wereferensi |
| Ukuchongwa | I-HPLC: Ixesha lokugcinwa kwencopho enkulu yesisombululo sesampulu kufuneka ihambelane naleyo yomgangatho wereferensi. |
| Ubunyulu | 98.0% ~ 102.0% (kwisiseko se-anhydrous kunye ne-solvent-free) |
| Ukujikeleziswa kwe-Optical | + 96.0 ° ~ + 100 ° |
| Ukufuma (KF) | ≤0.30% |
| Intsalela ekutshisweni | ≤0.10% |
| Iintsimbi ezinzima | ≤20ppm |
| Ukungcola Okunxulumeneyo A | ≤0.30% |
| Ukungcola Okunxulumeneyo B | ≤0.30% |
| Ukungcola Okunxulumeneyo C | ≤0.10% (2',3'-Di O-Acety-5'-deoxy-5-Fluoroytidine) |
| Ukungcola Okungachazwanga Okungatshatanga | ≤0.10% |
| Ukungcola okungachazwanga ngokupheleleyo | ≤0.50% |
| Ukungcola ngokupheleleyo | ≤1.5% |
| Intsalela yezinyibilikisi (GC) | |
| IMethanol | ≤3000ppm |
| I-Ethanol | ≤5000ppm |
| Dichloromethane | ≤600ppm |
| I-Ethyl Acetate | ≤5000ppm |
| Toluene | ≤800ppm |
| I-Pyridine | ≤200ppm |
| Hexane | ≤290ppm |
| Ubalo olupheleleyo lweAerobic Microbial | ≤200cfc/g |
| Igwele kunye noMngundo zibala | ≤50cfc/g |
| Umgangatho woVavanyo | I-United States Pharmacopoeia (USP) |
| Ukusetyenziswa | Umhlaza wamabele weMetastatic |
Iphakheji: Ibhotile, ingxowa yefoyile yeAluminiyam, igubu lekhadibhodi, 25kg/Igubu, okanye ngokwemfuno yomthengi.
Imeko yoGcino:Gcina kwizikhongozeli ezivaliweyo kwindawo epholileyo neyomileyo;Khusela ekukhanyeni, ukufuma kunye nokuhlaselwa zizinambuzane.
I-Capecitabine (i-CAS: 154361-50-9) luhlobo olutsha lweyeza lomlomo lwe-fluorinated pyrimidine.I-Capecitabine yaphuhliswa yi-Roche Pharmaceuticals, kwaye igama layo lezorhwebo yi-Xeloda.I-Capecitabine inokutshintsha kwi-vivo ibe yi-5- FU, i-anti-metabolizim fluorine pyrimidine deoxynucleoside carbamate ichiza elijolise kwiiseli zomhlaza ukuvimbela ukwahlukana kweeseli kunye nokuphazamisa i-RNA kunye neprotheni synthesis.Iziphumo zayo zibophelelwe kakhulu kwinqanaba le-TP enzyme yokubonakaliswa kwi-neoplastic tissue kunye ne-DPD enzyme kwi-vivo expression.Ifanelekile njengonyango olongezelelweyo kwizigulane ezinomhlaza webele we-primary okanye we-metastatic ongakhange uphendule kwi-paclitaxel okanye i-anthracycline antibiotics.Njengechiza le-anticancer, lisetyenziswa kakhulu ukunyanga umhlaza webele okwinqanaba eliphambili okanye we-metastatic, kunye nakunyango lomhlaza wemiphunga ongeyonxalenye encinci, umhlaza wepancreatic, umhlaza wesinyi, umhlaza we-rectal, umhlaza we-colon, umhlaza wesisu, kunye namanye amathumba aqinileyo. .
