Carvedilol CAS 72956-09-03 Ubunyulu > 99.0% (HPLC)
I-Shanghai Ruifu Chemical Co., Ltd. ngumenzi ohamba phambili weCarvedilol (CAS: 72956-09-03) enomgangatho ophezulu.I-Ruifu Chemical inokubonelela ngenkonzo yehlabathi jikelele, ixabiso elikhuphisanayo, inkonzo egqwesileyo, encinci kunye nezixa ezininzi ezikhoyo.Thenga iCarvedilol,Please contact: alvin@ruifuchem.com
AbaPhakathi abanxulumeneyo beCarvedilol
Igama leMchiza | Carvedilol |
Izithethantonye | 1-(9H-Carbazol-4-yloxy) -3-[[2-(2-Methoxyphenoxy)ethyl]amino]-2-Propanol;Igcisa;Cadilan;Carca;IiCardivas;UCarloc;IiCarvas;Carvedilol;Carvediol;Coreg;DQ 2466;Dilatrend;iDimitone;I-Eucardic;I-Korvasan;Kredex;Querto;Talliton;BM-14190 |
Ubume beStokhwe | Kwi-Stock, i-GMP yoRhwebo |
Inombolo yeCAS | 72956-09-3 |
Ifomula yeemolekyuli | I-C24H26N2O4 |
Ubunzima beMolekyuli | 406.48 g/mol |
Indawo yokunyibilika | 115.0 ukuba 119.0℃ |
Ukuxinana | 1.250±0.06 g/cm3 |
Ukunyibilika emanzini | Ayinyibilikiyo emanzini |
Ukunyibilika | Inyibilika kwiMethanol.Inyibilika kancinane kwi-Ethanol, i-Ether |
Ugcino Temp. | Indawo epholileyo neyomileyo (2~8℃) |
I-COA kunye ne-MSDS | Iyafumaneka |
Uphawu | Ruifu Chemical |
Izinto | ImiGangatho yokuHlola | Iziphumo |
Imbonakalo | Umgubo weCrystalline oMhlophe | Iyahambelana |
Ilahleko ekomisweni | ≤0.50% (105℃ ngeyure ezi-3) | 0.25% |
Intsalela kwi-Ignition | ≤0.10% | 0.07% |
Izinto ezinxulumeneyo | ||
Ukungcola ngokupheleleyo | ≤0.50% | Iyahambelana |
Ukungcola A | ≤0.20% | Iyahambelana |
Ukungcola C | ≤0.02% | Iyahambelana |
Nakuphi na Okunye Ukungacoceki komntu | ≤0.10% | Iyahambelana |
Iintsimbi ezinzima (Pb) | ≤10ppm | <10ppm |
Ubunyulu / Indlela yokuHlalutya | >99.0% (HPLC) | 99.72% |
I-Infrared Spectrum | Iyahambelana neSakhiwo | Iyahambelana |
Ukuqukumbela | Imveliso ivavanyiwe kwaye iyahambelana neenkcukacha |
Umqulu:Ibhotile, ingxowa yefoyile yeAluminiyam, 25kg/Igubu lekhadibhodi, okanye ngokwemfuno yomthengi.
Imeko yoGcino:Gcina kwisitya esivaliweyo.Gcina kwindawo epholileyo, eyomileyo (2~8℃) kunye nendawo yokugcina impahla engenamoya kude nezinto ezingahambelaniyo.Khusela ukukhanya kunye nokufuma.
Ukuhambisa ngenqanawe:Zisa kwihlabathi liphela ngomoya, ngeFedEx / DHL Express.Ukubonelela ngokukhawuleza nangokuthembekileyo.
Ukuthenga njani?Nceda uqhagamshelaneDr. Alvin Huang: sales@ruifuchem.com or alvin@ruifuchem.com
Amava Eminyaka Eli-15?Sineminyaka engaphezu kwe-15 yamava ekwenziweni nasekuthumeleni kumazwe angaphandle uluhlu olubanzi oluphezulu lwamayeza aphakathi okanye amachiza alungileyo.
Iimarike eziphambili?Thengisa kwimarike yasekhaya, eMntla Melika, eYurophu, eIndiya, eKorea, eJapan, eOstreliya, njl.
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Iikhowudi zeeNgcipheko N,Xn
Iingxelo zoMngcipheko 51/53-36/37/38-20/21/22
Iingxelo zoKhuseleko 61-36-26
RIDADR UN 3077 9/PG 3
WGK eJamani 3
RTECS UA8670000
I-HazardClass IRRITANT
PackingGroup III
Idatha yezinto ezinobungozi 72956-09-3(Idatha yezinto ezinobungozi)
Ubuthi be-LD50 ngomlomo kwinja:> 1gm/kg
I-Carvedilol (i-CAS: 72956-09-03) i-beta-blocker ye-vasodilating eluncedo kunyango lwe-hypertension kunye ne-angina pectoris.Ukongeza ekunciphiseni uxinzelelo lwegazi, i-carvedilol iyancipha ukuxhathisa kwe-vascular ngaphandle kwe-reflex tachycardia edla ngokuvela nge-vasodilators.Kuxelwe ukuba kunyanyezelwe kakuhle ngeziphumo zokonga izintso.
I-Carvedilol yaqala ukuqaliswa eBelgium kwi-1985. Le mveliso inokuthintela i-alpha kunye ne-beta receptors, akukho msebenzi wangaphakathi, kwiindawo eziphezulu zefashoni kunye ne-calcium antagonism.Inempembelelo enamandla yokuthintela i-beta receptors, enokwandisa imithambo yegazi, inciphise ukuxhathisa kwe-peripheral kunye noxinzelelo lwegazi olusezantsi, kwaye inefuthe elincinci kwimveliso yentliziyo kunye nesantya sentliziyo.Ikliniki ingasetyenziselwa uxinzelelo lwegazi oluphambili kunye ne-angina pectoris.
RU= | impendulo ephezulu ye-carvedilol kwisisombululo seSample |
rS= | impendulo ephezulu ye-carvedilol kwisisombululo esiPhakathi |
CS= | Uxinzelelo lwe-carvedilol kwisisombululo esiPhakathi (mg/mL) |
CU= | Uxinzelelo lweCarvedilol kwisisombululo seSampuli (mg/mL) |
rU | = | incopho yempendulo yekhompawundi ehambelanayo ehambelanayo okanye nakuphi na okunye ukungcola kwiSampuli yesisombululo |
rS | = | Incopho yempendulo yekhompawundi ehambelanayo ehambelanayo ukusuka kwisisombululo esiPhakathi.Ukubala ipesenti yomnye ukungcola komntu sebenzisa impendulo ephezulu ye-carvedilol. |
CS | = | Ugxininiso lwekhompawundi ehambelanayo ehambelanayo kwisisombululo soMgangatho (mg / mL).Ukubala ipesenti yazo naziphi na ezinye izinto ezingcolileyo ze-CS, sebenzisa i-concentration ye-USP Carvedilol RS. |
CU | = | Uxinzelelo lweCarvedilol kwisisombululo seSampuli (mg/mL) |
Igama | Ixesha lokuGcina isihlobo | Iinqobo zoKwamkelwa, NMT (%) | |
Ikhompawundi enxulumene neCarvedilol Ea | 0.35 | 0.1 | |
Ikhompawundi enxulumene neCarvedilol Ab | 0.52 | 0.1 | |
Carvedilol bisalkylpyrocatechol derivative (ukuba ikhona)c | 0.70 | 0.15 | |
Carvedilol | 1.0 | - | |
Ikhompawundi enxulumene neCarvedilol Cd | 3.6 | 0.02 | |
Ikhompawundi enxulumene neCarvedilol De | 5.0 | 0.1 | |
Ikhompawundi enxulumene neCarvedilol Bf | 8.5 | 0.1 | |
Nakuphi na okunye ukungcola komntu | - | 0.10 | |
Ukungcola okupheleleyo | - | 0.5g | |
i-2-(2-Methoxyphenoxy) ethyl amine. b 1-(4-(2-Hydroxy-3-(2-(2-methoxyphenoxy)ethylamino)propoxy)-9H-carbazol-9-yl)-3-(2-(2-methoxyphenoxy)ethylamino) propan-2 -ol. c 3,3¢-{2,2¢-[1,2-Phenylenebis(oxy)]bis(ethane-2,1-diyl)}bis(azanediyl)bis(1-(9H-carbazol-4-yloxy) propan-2-ol). d 1-(9H-Carbazol-4-yloxy) -3-(benzyl(2-(2-methoxyphenoxy)ethyl)amino)propan-2-ol. e 4-(Oxiran-2-ylmethoxy) -9H-carbazole. f 3,3¢-(2-(2-Methoxyphenoxy)ethylazanediyl)bis(1-(9H-carbazol-4-yloxy)propan-2-ol). g Ukungakhathaleli nakuphi na ukungcola okungaphantsi kwe-0.01%. |
Ixesha (umzuzu) | Isisombululo A (%) | Isisombululo B (%) |
---|---|---|
0 | 22 | 78 |
20 | 22 | 78 |
33 | 38 | 62 |
45 | 38 | 62 |
55 | 55 | 45 |
65 | 55 | 45 |
68 | 22 | 78 |
80 | 22 | 78 |
rU | = | impendulo encopho yokungcola ngakunye kwiSampuli yesisombululo |
rT | = | isimbuku sazo zonke iimpendulo eziphezulu kwiSampuli yesisombululo |
Igama | Isihlobo Ukugcinwa Ixesha | Ukwamkelwa Iikhrayitheriya, NMT (%) | |
---|---|---|---|
Ikhompawundi enxulumene neCarvedilol Aa | 0.7 | 0.1 | |
Carvedilol | 1.0 | - | |
Ikhompawundi enxulumene neCarvedilol Fb | 1.2 | 0.1c | |
N-Isopropylcarvedilold | 1.6 | 0.1 | |
Ikhompawundi enxulumene neCarvedilol Ce | 1.8 | 0.02 | |
Ikhompawundi enxulumene neCarvedilol Bf | 2.1 | 0.1 | |
Biscarbazoleg | 3 | 0.1 | |
Nakuphi na okunye ukungcola komntu | - | 0.1 | |
Ukungcola okupheleleyo | - | 0.5 | |
i-1-(4-(2-Hydroxy-3-(2-(2-methoxyphenoxy)ethylamino)propoxy)-9Hcarbazol-9-yl)-3-(2-(2-methoxyphenoxy)ethylamino) propan-2-ol . b 1-(2-(2-Methoxyphenoxy) ethylamino) -3-(6,7,8,9-tetrahydro-5H-carbazol-4-yloxy)propan-2-ol. c Oku kungcola kubalwa kusetyenziswa inkqubo phantsi kwe-Organic Impurities, Inkqubo yesi-3: I-Carvedilol eNxulumene neCompound F. d 1-(H-Carbazol-4-yloxy) -3-[[2-(2-methoxyphenoxy) ethyl]N-isopropylamino] -2-propanol. e 1-(9H-Carbazol-4-yloxy)-3-(benzyl(2-(2-methoxyphenoxy)ethyl)amino)propan-2-ol. f 3,3'-(2-(2-Methoxyphenoxy)ethylazanediyl)bis(1-(9H-carbazol-4-yloxy)propan-2-ol). g 1,3-Bis-(9H-carbazol-4-yloxy) -2-propanol. |
rU | = | impendulo ephezulu ye-carvedilol ehambelana nekhompawundi F ukusuka kwisisombululo seSample |
rT | = | Isixa seempendulo eziphezulu ze-carvedilol kunye ne-carvedilol ezinxulumene nekhompawundi F kwisisombululo seSampuli |
F | = | umba wempendulo ehambelanayo, 1.1 |
1-(4-(2-Hydroxy-3-(2-(2-methoxyphenoxy)ethylamino)propoxy)-9H-carbazol-9-yl)-3-(2-(2-methoxyphenoxy)ethylamino) propan-2- ol.
C36H43N3O7 629.74
3,3'-(2-(2-Methoxyphenoxy)ethylazanediyl)bis(1-(9H-carbazol-4-yloxy)propan-2-ol).
C39H39N3O6 645.74
1-(9H-Carbazol-4-yloxy)-3-(benzyl(2-(2-methoxyphenoxy)ethyl)amino)propan-2-ol.
C31H32N2O4 496.60
4-(Oxiran-2-ylmethoxy) -9H-carbazole.
C15H13NO2 239.27
2-(2-Methoxyphenoxy)ethyl amine.
C9H13NO2 167.21
Umxube malunga ne-0.1% ye-carvedilol ehambelana nekhompawundi F (1- (2- (2-Methoxyphenoxy) ethylamino) -3- (2,3,4,9-tetrahydro-1H-carbazol-5-yloxy) propan-2-ol) kwimatrix yeziyobisi carvedilol.