I-Daclatasvir Dihydrochloride Intermediate CAS 1007882-23-6 Ubunyulu > 98.0% (HPLC)
I-Shanghai Ruifu Chemical Co., Ltd. ngumenzi ohamba phambili we-Daclatasvir Dihydrochloride Intermediate (CAS: 1007882-23-6) enomgangatho ophezulu.I-Ruifu Chemical inokubonelela ngenkonzo yehlabathi jikelele, ixabiso elikhuphisanayo, amancinci kunye nenani elikhulu elikhoyo.Thenga iDaclatasvir Dihydrochloride Intermediates,Please contact: alvin@ruifuchem.com
| Igama leMchiza | I-Di-tert-Butyl (2S,2'S)-2,2'-(4,4'-Biphenyldiylbis(1H-imidazole-5,2-diyl))di(1-Pyrrolidinecarboxylate) |
| Izithethantonye | I-Daclatasvir ePhakathi Ⅱ;I-Dacaltasvir ePhakathi 02;Daclatasvir T-Butyl Ester;I-Bis (2-Methyl-2-Propanyl) (2S,2'S) -2,2'-[4,4'-Biphenyldiylbis(1H-Imidazole-4,2-diyl)]di(1-Pyrrolidinecarboxylate);I-Di-tert-butyl 2,2′-([1,1′-Biphenyl]-4,4′-diylbis(1H-Imidazole-5,2-diyl))(2S,2'S)-bis(Pyridineidine-1- Carboxylate);(2S,2'S)-2,2'-([1,1'-Biphenyl]-4,4'-diyldi-1H-Imidazole-5,2-diyl) bis-1-Pyrrolidinecarboxylic Acid 1,1'-Bis (1,1-Dimethylethyl) Ester;Ukungacoceki kweDaclatasvir 4 |
| Ubume beStokhwe | Kwi-Stock, iMveliso yoRhwebo |
| Inombolo yeCAS | 1007882-23-6 |
| Ifomula yeemolekyuli | I-C40H51ClN8O6 |
| Ubunzima beMolekyuli | 775.35 g/mol |
| Indawo yokubilisa | 890.2±65.0℃ kwi-760 mmHg |
| Ukuxinana | 1.220±0.06 g/cm3 |
| I-COA kunye ne-MSDS | Iyafumaneka |
| Imvelaphi | Shanghai, China |
| Udidi | Umbindi weDaclatasvir Dihydrochloride (CAS: 1009119-65-6) |
| Uphawu | Ruifu Chemical |
| Izinto | Iinkcukacha | Iziphumo |
| Imbonakalo | Umgubo oMthubi oKhanyayo ukuya kumthubi | Umgubo oMthubi oKhanya |
| Ilahleko ekomisweni | <1.00% | 0.65% |
| Ukungacoceki okuphezulu okukodwa | <1.00% | 0.45% |
| Ukungcola ngokupheleleyo | <2.00% | 1.24% |
| Ubunyulu / Indlela yokuHlalutya | >98.0% (HPLC) | 98.76% |
| I-Infrared Spectrum | Ngokungqinelana noLwakhiwo | Iyahambelana |
| I-1H NMR Spectrum | Ngokungqinelana noLwakhiwo | Iyahambelana |
| Ukuqukumbela | Imveliso ivavanyiwe kwaye ihambelana neenkcukacha ezinikiweyo | |
| Isicelo | Umbindi weDaclatasvir Dihydrochloride (CAS: 1009119-65-6) | |
Umqulu:Ibhotile eFluorinated, iAluminium foil bag, 25kg/Cardboard Drum, okanye ngokwemfuno yomthengi.
Imeko yoGcino:Gcina isikhongozeli sivaliwe kwaye usigcine kwindawo epholileyo, eyomileyo nengena umoya kakuhle kude nezinto ezingahambelaniyo.Khusela ukukhanya kunye nokufuma.
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Ukuthenga njani?Nceda uqhagamshelaneDr. Alvin Huang: sales@ruifuchem.com or alvin@ruifuchem.com
Amava Eminyaka Eli-15?Sineminyaka engaphezu kwe-15 yamava ekwenziweni nasekuthumeleni kumazwe angaphandle uluhlu olubanzi oluphezulu lwamayeza aphakathi okanye amachiza alungileyo.
Iimarike eziphambili?Thengisa kwimarike yasekhaya, eMntla Melika, eYurophu, eIndiya, eKorea, eJapan, eOstreliya, njl.
Iingenelo?Umgangatho ophezulu, ixabiso elifikelelekayo, iinkonzo zengcali kunye nenkxaso yobugcisa, ukuhanjiswa ngokukhawuleza.
UmgangathoIsiqinisekiso?Inkqubo yokulawula umgangatho ongqongqo.Izixhobo zobuchwephesha zokuhlalutya ziquka i-NMR, LC-MS, GC, HPLC, ICP-MS, UV, IR, OR, KF, ROI, LOD, MP, Clarity, Solubility, Microbial limit test, njl.
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Factory Audit?Uphicotho-zincwadi lwasefektri wamkelekile.Nceda wenze idinga kwangaphambili.
MOQ?Akukho MOQ.Umyalelo omncinci wamkelekile.
Ixesha lokuzisa? Ukuba ngaphakathi kwesitokhwe, ukuhanjiswa kweentsuku ezintathu kuqinisekisiwe.
Ezothutho?Nge-Express (FedEx, DHL), ngoMoya, ngoLwandle.
Amaxwebhu?Emva kwenkonzo yokuthengisa: I-COA, i-MOA, i-ROS, i-MSDS, njl.
Udibaniso lweSiko?Inokubonelela ngeenkonzo zesiko lokudibanisa ukuze zilungele iimfuno zakho zophando.
Immimiselo yokuhlawula?I-invoyisi yeProforma iya kuthunyelwa kuqala emva kokuqinisekiswa kwe-odolo, efakwe kwiinkcukacha zethu zebhanki.Intlawulo nge-T / T (i-Telex Transfer), i-PayPal, i-Western Union, njl.
I-Di-tert-Butyl (2S,2'S)-2,2'-(4,4'-Biphenyldiylbis(1H-imidazole-5,2-diyl))di(1-Pyrrolidinecarboxylate) (CAS: 1007882-23-6) yindawo ephakathi yeDaclatasvir Dihydrochloride (CAS: 1009119-65-6).
I-Daclatasvir (i-Daklinza) ifumene isimo "sophononongo oluphambili", idityaniswe ne-Sorafenib kunyango lwe-genotype III yezigulane zabantu abadala abane-hepatitis C engapheliyo. usulelo ngaphandle kokubambisana kunye ne-interferon okanye i-ribavirin.I-Interferon kunye ne-Ribavirin ngamachiza amabini avunywe yi-FDA kunyango lwe-virus ye-hepatitis C.I-Hepatitis C sisifo sentsholongwane esinokubangela ukuvuvukala kwesibindi, okukhokelela ekunciphiseni ukusebenza kwesibindi okanye ukungaphumeleli kwesibindi.Uninzi lwezigulana ezosulelwe yi-hepatitis C azinazimpawu de kubonakale umonakalo wesibindi, onokuthi uthabathe iminyaka eliqela.Ehlabathini lonke, i-genotype III i-hepatitis C yi-genotype yesibini eqhelekileyo ye-hepatitis C emva kwe-genotype 1 ye-hepatitis C kwaye ithathwa njengenye yezona zifo ze-genotype eziphikisayo.I-Daklinza yi-pan-genotype NS5A replication complex inhibitor, kunye nokusebenza kakuhle kokuthintela ukuphindaphinda kwe-RNA kunye nendibano yentsholongwane, i-antiviral effect ezimbini.Kwizifundo ze-in vitro, i-Daklinza ibonakaliswe ukuba ine-anti-viral effect ngokuchasene ne-genotype 1 ~ 6 intsholongwane ye-hepatitis C.I-Daklinza ikhatshwa sisilumkiso sokuba indibaniselwano ye-amiodarone, i-Daklinza kunye ne-Sofosbuvir inokubangela ukubetha kwentliziyo okucuthe kakhulu.I-Daklinza ithebhulethi yomlomo ene-dose ekhuthazwayo ye-60 mg ngamaxesha e-1 / d, ngokubambisana ne-Sofosbuvir kwiiveki ezili-12 zizonke.
Uphando kunye nenkampani yophuhliso: Bristol-Myers Squibb.
Uncwadi lwePatent: WO 2008021927A2 (Agasti 9, 2007).
Ixesha lokuthengisa: NgoJulayi 24, i-2015 edweliswe e-United States, igama lezorhwebo Daklinza.
Izalathisi: Isetyenziswa ngokudibeneyo Sofosbuvir unyango genotype 3 chronic hepatitis C (HCV) usulelo.
Indlela yokwenza: i-HCV ye-nonstructural protein 5A (NS5A) inhibitors.Ukuphendula okungalunganga: intloko kunye nokudinwa.
Ukuqulunqwa kunye neenkcukacha: Iipilisi, i-30 kunye ne-60mg.
