Risperidone CAS 106266-06-2 Uvavanyo 98.0~102.0%
I-Shanghai Ruifu Chemical Co., Ltd. ngumenzi ohamba phambili weRisperidone (CAS: 106266-06-2) enomgangatho ophezulu.I-Ruifu Chemical inokubonelela ngenkonzo yehlabathi jikelele, ixabiso elikhuphisanayo, inkonzo egqwesileyo, encinci kunye nezixa ezininzi ezikhoyo.Thenga iRisperidone,Please contact: alvin@ruifuchem.com
| Igama leMchiza | I-Risperidone |
| Izithethantonye | 3-[2-[4-(6-Fluoro-1,2-Benzisoxazol-3-yl)-1-Piperidinyl]ethyl]-6,7,8,9-Tetrahydro-2-Methyl-4H-Pyrido[1 ,2-a]pyrimidin-4-enye;Risperdal;Risperidal;Risperdal Consta;Rispolept;Risperin;I-Rispolin;iSequinan;Risperdal M-Tab |
| Ubume beStokhwe | Kwi-Stock, iMveliso yoRhwebo |
| Inombolo yeCAS | 106266-06-2 |
| Ifomula yeemolekyuli | I-C23H27FN4O2 |
| Ubunzima beMolekyuli | 410.49 g/mol |
| Indawo yokunyibilika | 170.0 ukuya 174.0℃ |
| Ukuxinana | 1.38±0.10 g/cm3 |
| IKlasi yeeNgozi | 6.1;Ityhefu |
| I-COA kunye ne-MSDS | Iyafumaneka |
| Imvelaphi | Shanghai, China |
| Uphawu | Ruifu Chemical |
| Izinto | Iinkcukacha | Iziphumo |
| Imbonakalo | Mhlophe ukuya kwi-Off-White Powder | Iyahambelana |
| Isazisi A | Ukufunxwa kwe-infrared | Iyahambelana |
| Isazisi B | Ixesha lokuGcina: Ihambelana neNgcaciso yeNgcaciso | Iyahambelana |
| Ilahleko ekomisweni | <0.50% | 0.12% |
| Intsalela kwi-Ignition | <0.10% | 0.07% |
| Iintsimbi ezinzima | <0.001% | <0.001% |
| IiCompounds eziyeleleneyo | ||
| E-Oxime | <0.20% | <0.20% |
| Z-Oxime | <0.20% | <0.20% |
| 9-Hydroxyrisperidone | <0.20% | <0.20% |
| I-5-Fluororisperidone | <0.20% | <0.20% |
| 6-Methylrisperidone | <0.20% | <0.20% |
| Nakuphi na Ukungcola Okungaziwa | <0.10% | <0.10% |
| Ukungcola ngokupheleleyo | <0.30% | <0.30% |
| Isivavanyi | 98.0 ~ 102.0% (Ibalwe kwisiseko esomileyo) | 100.52% |
| Ukuqukumbela | Imveliso ivavanyiwe kwaye ihambelana ne-USP 35 Standard | |
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I-Risperidone
C23H27FN4O2 410.48
4H-Pyrido[1,2-a]pyrimidin-4-enye, 3-[2-[4-(6-fluoro-1,2-benzisoxazol-3-yl)-1-piperidinyl]ethyl]-6,7 ,8,9-tetrahydro-2-methyl-.
3- [2-[4-(6-Fluoro-1,2-benzisoxazol-3-yl)piperidino]ethyl]-6,7,8,9-tetrahydro-2-methyl-4H-pyrido[1,2- a]pyrimidin-4-enye [106266-06-2].
» I-Risperidone iqulethe ngaphantsi kweepesenti ze-98.0 kwaye ingabi ngaphezu kwe-102.0 ipesenti ye-C23H27FN4O2, ibalwa kwisiseko esomileyo.
Ukupakishwa kunye nokugcinwa- Gcina kwizikhongozeli ezivalwe kakuhle.Gcina kwiqondo lokushisa.
Imigangatho yezalathiso ye-USP <11>-
USP Risperidone RS
3- [2-[4-(6-fluoro-1,2-benzisoxazol-3-yl)piperidino]ethyl]-6,7,8,9-tetrahydro-2-methyl-4H-pyrido[1,2- a]pyrimidin-4-enye 410.48 CAS-106266-06-2
USP Risperidone System Ukufaneleka Umxube RS
Iqulethe i-risperidone kwaye malunga ne-0.2% nganye kwezi zilandelayo:
Z-Oxime-3-[2-[4-[(Z))-(2,4-difluorophenyl)(hydroxyimino)methyl]piperidin-1-yl]ethyl]-2-methyl-6,7,8,9- tetrahydro-4H-pyrido [1,2-a] pyrimidin-4-enye.
I-9-Hydroxyrisperidone-(6RS)-3-[2-[4-(6-fluoro-1,2-benzisoxazol-3-yl)piperidin-1-yl]ethyl]-2,6-dimethyl-6,7, I-8,9-tetrahydro-4H-pyrido [1,2-a] pyrimidin-4-enye.
I-6-Methylrisperidone-(6RS)-3-[2-[4-(6-fluoro-1,2-benzisoxazol-3-yl)piperidin-1-yl]ethyl]-2,6-dimethyl-6,7, I-8,9-tetrahydro-4H-pyrido [1,2-a] pyrimidin-4-enye.
[Qaphela-Lo mxube uqulethe i-risperidone, i-Z-oxime, i-9-hydroxyrisperidone, kunye ne-6-methylrisperidone.]
Isazisi-
A: I-Infrared Absorption <197K>.
B: Ixesha lokugcinwa kwencopho enkulu kwichromatogram yoLungiselelo lwe-Assay ihambelana naleyo kwichromatogram yoLungiselelo oluMgangatho, njengoko lufunyenwe kwi-Assay.
Ilahleko ekumiseni <731>- Yomisa kwi-vacuum kwi-80 kwiiyure ze-4: ilahlekelwa ngaphezu kwe-0.5% yobunzima bayo.
Intsalela ekutshisweni <281>: hayi ngaphezulu kwe-0.1%, isampula yovavanyo lwe-2.0-g isetyenziswa.
Iintsimbi ezinzima, Indlela II <231>: 0.001%.
Iikhompawundi ezinxulumene-
Isisombululo se-Buffer, Isisombululo A, Isisombululo B, isigaba se-Mobile, i-Diluent, isisombululo sokufaneleka kweSistim, kunye ne-Chromatographic system-Lungisa njengoko kubhaliwe kwi-Assay.
Isisombululo esisemgangathweni-Sebenzisa ukulungiswa okuPhakathi, okulungiselelwe njengoko kuyalelwe kwi-Assay.
Isisombululo sovavanyo-Sebenzisa ukulungiswa koVavanyo.
Inkqubo-Tofa imiqulu elinganayo (malunga ne-10 µL) yoMgangatho wesisombululo kunye nesisombululo soVavanyo kwichromatograph, kwaye urekhode ichromatogram.Chonga ukungcola usebenzisa amaxesha okugcina anxulumeneyo anikwe kwiThebhile 1, kwaye ulinganise iimpendulo eziphakamileyo.Bala ipesenti yekhompawundi nganye enxulumene nerisperidone kwinxalenye yeRisperidone ethathwe yifomula:
100(CS /CU)(rU / rS)(1/F)
apho i-CS kunye ne-CU zizigxina, kwi-mg nge-mL, ye-risperidone kwisisombululo esiPhakathi kunye nesisombululo soVavanyo ngokulandelanayo;I-rU yindawo encopho yokungcola ngakunye okufunyenwe kwisisombululo soVavanyo;I-rS yindawo ephezulu ye-risperidone efunyenwe kwisisombululo esiPhakathi;kunye ne-F yimpendulo ehambelanayo yokungcola ngakunye kwi-risperidone.Ukongeza kokungagqithisi kwimida kwiThebhile 1, akukho ngaphezu kwe-0.10% yokungcola okungaziwayo (sebenzisa ixabiso le-F ye-1.0) lifunyenwe kwaye akukho ngaphezu kwe-0.30% yokungcola okupheleleyo kufunyenwe.Ukungakhathaleli iincopho zokungcola ezingaphantsi kwe-0.05%.
Uluhlu loku-1
Ixesha eliNxulumeneyo lokuGcinwa kweNdawo (RRT) Umba weMpendulo eNxulumeneyo (F) Umda (%)
E-oxime1 0.60 1.0 NMT 0.20
Z-oxime2 0.67 0.63 NMT 0.20
9-hydroxyrisperidone3 0.76 0.92 NMT 0.20
5-fluororisperidone4 0.94 1.0 NMT 0.20
I-Risperidone 1.0 1.0 -
6-methylrisperidone5 1.2 0.95 NMT 0.20
I-1 3-[2-[4-[(E))-(2,4-Difluorophenyl) (hydroxyimino)methyl]piperidin-1-yl]ethyl]-2-methyl-6,7,8,9-tetrahydro-4H -pyrido[1,2-a]pyrimidin-4-enye
I-2 3-[2-[4-[(Z))-(2,4-Difluorophenyl)(hydroxyimino)methyl]piperidin-1-yl]ethyl]-2-methyl-6,7,8,9-tetrahydro-4H -pyrido[1,2-a]pyrimidin-4-enye
3 (9RS)-3-[2-[4-(6-Fluoro-1,2-benzisoxazol-3-yl)piperidin-1-yl]ethyl]-9-hydroxy-2-methyl-6,7,8 ,9-tetrahydro-4H-pyrido[1,2-a]pyrimidin-4-enye
4 3-[2-[4-(5-Fluoro-1,2-benzisoxazol-3-yl)piperidin-1-yl]ethyl]-2-methyl-6,7,8,9-tetrahydro-4H-pyrido [1,2-a]pyrimidin-4-enye
5 (6RS)-3-[2-[4-(6-Fluoro-1,2-benzisoxazol-3-yl)piperidin-1-yl]ethyl]-2,6-dimethyl-6,7,8,9 -tetrahydro-4H-pyrido [1,2-a] pyrimidin-4-enye
Isivavanyi-
Isisombululo se-buffer- Nciba i-15.4 g ye-ammonium acetate kwi-1 L yamanzi.Lungisa nge-10% ye-acetic acid kwi-pH ye-6.5, kwaye udibanise.
Isisombululo A-Xuba i-100 mL yesisombululo se-Buffer kunye ne-150 mL ye-methanol kwi-1000-mL ye-volumetric flask, kwaye uhlambulule ngamanzi ukuya kwivolumu.
Isisombululo B- Xuba i-100 mL yesisombululo se-Buffer kunye ne-850 mL ye-methanol kwi-1000-mL ye-volumetric flask, kwaye uhlambulule ngamanzi ukuya kwivolumu.
Isigaba esiphathwayo-Sebenzisa imixube eguquguqukayo yeSisombululo A kunye neSisombululo B njengoko kumiselwe inkqubo yeChromatographic.Yenza uhlengahlengiso xa kukho imfuneko (jonga ukufaneleka kweNkqubo phantsi kweChromatography 621).
Diluent-Xuba i-100 mL yesisombululo se-Buffer kunye ne-900 mL yamanzi kunye ne-1000 mL ye-methanol.
Isisombululo sokufaneleka kwenkqubo-Lungisa i-1 mg nge-mL isisombululo se-USP Risperidone System Suitability Mixture RS kwi-Diluent.
Ukulungiswa okusemgangathweni-Nxibilikisa isixa esikaliniweyo ngokuchanekileyo se-USP Risperidone RS kwi-Diluent, kwaye nciphisa ngokobuninzi, kunye ne-stepwise ukuba kuyimfuneko, kunye ne-Diluent ukufumana isisombululo esinoxinzelelo olwaziwayo malunga ne-1.0 mg nge-mL nganye.
Ukulungiswa kovavanyo-Nyibilikisa isixa esinomlinganiso ngokuchanekileyo weRisperidone kwiDiluent, kwaye unciphise ngokobungakanani, kwaye ngokwenyathelo xa kuyimfuneko, ngeDiluent ukufumana isisombululo esinoxinzelelo olumalunga ne-1.0 mg ngemL nganye.
Inkqubo yeChromatographic (jonga i-Chromatography <621>)- I-chromatograph yolwelo ixhotyiswe nge-275-nm detector kunye ne-4.6-mm × 10-cm ikholamu equlethe i-3-µm yokupakisha i-L1.Izinga lokuhamba malunga ne-1.5 mL ngomzuzu.Ubushushu bekholomu bugcinwa kwi-35. I-chromatograph ihlelwe ngolu hlobo lulandelayo.
Ixesha (imizuzu) Isisombululo A (%) Isisombululo B (%) Uvavanyo
0–1 70 30 isokhrasi
1–20 70®5 30®95 umyinge womda
20–25 5 95 isokhrasi
25–27 5®70 95®30 umyinge womda
27–35 70 30 ukulungelelaniswa kwakhonaTofa isisombululo sokufaneleka kweSistim.Rekhoda iimpendulo eziphakamileyo njengoko ziqondiswe kwiNkqubo, kwaye uchonge iincopho ngenxa ye-Z-oxime, i-9-hydroxyrisperidone, i-6-methylrisperidone, kunye ne-risperidone usebenzisa amaxesha okugcinwa okuhambelanayo (RRT) ukusuka kwiThebhile 1;isisombululo, R, phakathi kwe-Z-oxime kunye ne-9-hydroxyrisperidone ayikho ngaphantsi kwe-2.8;i-tailing factor ye-risperidone ayikho ngaphezu kwe-1.5;kunye nokutenxa komgangatho ozalanayo wokutofa okuphindaphindayo akukho ngaphezu kwe-2.0% kwincopho yerisperidone.
Inkqubo- Ngokwahlukileyo tofa imithamo elinganayo (malunga ne-10 µL) yoLungiso oluMgangatho kunye nolungiselelo lwe-Assay kwichromatograph, kwaye ulinganise iimpendulo zencopho yerisperidone.Bala ubuninzi, kwipesenti yeC23H27FN4O2, kwisahlulo seRisperidone esithathwe ngefomula:
100(CS /CU)(rU / rS)
apho i-CS kunye ne-CU zizigxina, kwi-mg nge-mL, ye-risperidone kwi-Standard setting kunye nokulungiswa kwe-Assay, ngokulandelanayo;kunye ne-rU kunye ne-rS yincopho yeempendulo ezifunyenwe kulungiselelo loVavanyo kunye nolungiselelo loMgangatho, ngokulandelelanayo.
Ukuthenga njani?Nceda uqhagamshelaneDr. Alvin Huang: sales@ruifuchem.com or alvin@ruifuchem.com
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Udidi lweeNgozi 6.1(a)
Ukupakisha Iqela II
I-Risperidone (i-CAS: i-106266-06-2) inefuthe elichasayo kwi-5HT2 i-receptors kunye ne-D2 receptors.I-Risperidone isetyenziselwa i-schizophrenia ebukhali kwaye engapheliyo.Amachiza okulwa neengqondo.I-Risperidone isetyenziselwa unyango lwe-schizophrenia ebukhali kunye nengapheliyo kunye nezinye iimpawu ezicacileyo ze-psychotic (ezifana nokubona izinto ezingekhoyo, inkohliso, ukuphazamiseka kwengqondo, ubutshaba, ukukrokrela) kunye neempawu ezimbi (ezifana nokungaphenduli, ukungakhathali kweemvakalelo kunye nokungakhathali kwentlalo, ezimbalwa. amazwi).Kwakhona kunokunciphisa iimpawu ezichaphazelekayo ezinxulumene ne-schizophrenia (ezifana nokudandatheka, ukuziva unetyala, ukuxhalaba).Kwizigulana iRisperidone esebenzayo kuzo kunyango olubukhali, kwinqanaba lolondolozo lonyango, iRisperidone inokuqhubeka nokudlala ukusebenza kwayo kwezonyango.I-Risperidone, ke ngoko, inesenzo sonyango kuzo zombini iimpawu ezintle kunye nezibi ze-schizophrenia kwaye ivelisa iziphumo ebezingalindelekanga ezimbalwa kakhulu ngakumbi iimpawu ze-extrapyramidal xa kuthelekiswa ne-antipsychotics ecocekileyo ye-D2 esetyenziswa ngokuqhelekileyo.Ikwanayo nolawulo lokurhoxa kotywala kunye nokuba likhoboka lecocaine.
