I-4-Amino-5-Chloro-2,3-Dihydrobenzofuran-7-Carboxylic Acid CAS 123654-26-2 Prucalopride Succinate Intermediate Purity ≥98.0% (HPLC)
I-Shanghai Ruifu Chemical ngumenzi ohamba phambili we-4-Amino-5-Chloro-2,3-Dihydrobenzofuran-7-Carboxylic Acid (CAS: 123654-26-2) enomgangatho ophezulu.I-Ruifu Chemical inokubonelela ngenkonzo yehlabathi jikelele, ixabiso elikhuphisanayo, inkonzo egqwesileyo, encinci kunye nezixa ezininzi ezikhoyo.Thenga iPrucalopride Succinate Intermediates,Please contact: alvin@ruifuchem.com
| Igama leMchiza | 4-Amino-5-Chloro-2,3-Dihydrobenzofuran-7-Carboxylic Acid |
| Izithethantonye | I-4-Amino-5-Chlorocoumaran-7-Carboxylic Acid;I-4-Amino-5-Chloro-2,3-Dihydrobenzo[b]furan-7-Carboxylic Acid;I-4-Amino-5-Chloro-2,3-Dihydro-1-Benzofuran-7-Carboxylic Acid;I-4-Amino-5-Chloro-2,3-Dihydro-7-Benzofurancarboxylic Acid;Ukungacoceki kwePrucalopride A;I-Prucalopride Succinate Ukungcola-2 |
| Ubume beStokhwe | Kwi-Stock, iMveliso yoRhwebo |
| Inombolo yeCAS | 123654-26-2 |
| Ifomula yeemolekyuli | C9H8ClNO3 |
| Ubunzima beMolekyuli | 213.62 g/mol |
| Indawo yokunyibilika | 242℃(Disemba) |
| Indawo yokubilisa | 406.5±45.0℃ |
| Ukuxinana | 1.566 |
| I-COA kunye ne-MSDS | Iyafumaneka |
| Imvelaphi | Shanghai, China |
| Udidi | Phakathi kwePrucalopride Succinate (CAS: 179474-85-2) |
| Uphawu | Ruifu Chemical |
| Izinto | ImiGangatho yokuHlola | Iziphumo |
| Imbonakalo | I-Off-White ukuya kuLight-Red Solid | UkuKhanya-Obomvu Okuqinileyo |
| Amanzi nguKarl Fischer | ≤1.00% | 0.35% |
| Intsalela kwi-Ignition | <0.20% | 0.08% |
| Iintsimbi ezinzima (Pb) | ≤20ppm | <10ppm |
| Ukungacoceki Okukodwa | ≤1.00% | Iyahambelana |
| Ukungcola ngokupheleleyo | ≤2.00% | Iyahambelana |
| Ubunyulu / Indlela yokuHlalutya | ≥98.0% (HPLC) | 99.6% |
| I-Infrared Spectrum | Iyahambelana neSakhiwo | Iyahambelana |
| I-1 H NMR Spectrum | Iyahambelana neSakhiwo | Iyahambelana |
| Ukuqukumbela | Imveliso ivavanyiwe kwaye iyahambelana neenkcukacha ezinikiweyo | |
Umqulu:Ibhotile, ingxowa yefoyile yeAluminiyam, 25kg/Igubu lekhadibhodi, okanye ngokwemfuno yomthengi.
Imeko yoGcino:Gcina isikhongozeli sivalwe ngokuqinileyo kwaye usigcine kwindawo epholileyo, eyomileyo (2~8℃) kunye nendawo yokugcina impahla engena moya ikude kwizinto ezingahambelaniyo.Khusela ukukhanya kunye nokufuma.
Ukuhambisa ngenqanawe:Zisa kwihlabathi liphela ngomoya, ngeFedEx / DHL Express.Ukubonelela ngokukhawuleza nangokuthembekileyo.
Le mveliso yi-4-Amino-5-Chloro-2,3-Dihydrobenzofuran-7-Carboxylic Acid, umxholo we-C12H12ClNO4 awuyi kuba ngaphantsi kwe-98.0%, ibalwa kwisiseko se-anhydrous.
[iiProperties] Le mveliso imhlophe-mhlophe ukuya kukukhanya-bomvu okuqinileyo.
[Jonga]
Thatha isixa esifanelekileyo sale mveliso (malunga ne-0.5g) yamanzi, yongeza i-solvent (methanol: N, N-dimethylformamide = 50:50), kwaye uyichithe ngokwendlela yokumisela amanzi (Isihlomelo Ⅷ M, indlela yokuqala A).Sebenzisa amathontsi ovavanyo lukaFisher ukumisela de isisombululo sitshintshe ukusuka kumthubi okhanyayo ukuya kubomvu-mdaka obonisa indawo yokugqibela, kwaye wenze olunye uvavanyo olungenanto.Bala ngokwefomula ilandelayo: umthamo wamanzi akufanele udlule i-1.00%.
Isiqulatho sokufuma (%) = (AB) F/W×100%
Apho, A ngumthamo wolwelo lweFisher olusetyenziswe yimveliso yovavanyo (ml);
B ngumthamo wolwelo lovavanyo lukaFisher olusetyenziswe sisithuba esingenanto, ml;
F bubunzima besisombululo sovavanyo lukaFisher olulingana namanzi nge-1ml, mg;
W ubunzima bemveliso yovavanyo, mg
Into enxulumeneyo
Ngokwendlela ephantsi kwe "Into yokulinganisa isiqulatho", ukuba kukho iincopho zokungcola kwichromatogram yesisombululo sovavanyo, indawo encopho yokungcola okukodwa ayiyi kuba nkulu kumaxesha ali-10 (1.0%) yendawo ephezulu yolawulo isisombululo, kunye nesamba sendawo encopho yazo zonke izinto ezingcolileyo aziyi kuba zikhulu ngaphezu kwamaxesha angama-20 (2.0%) ommandla ophambili wesisombululo solawulo.
[Umiselo lwesiqulatho] Ngokwekhromatography yolwelo olusebenzayo oluphezulu (Isihlomelo VI D).
Ijeli ye-silica edityanisiweyo ye-Octadecylsilane yasetyenziswa njenge-filler yeemeko zechromatographic kunye novavanyo lokufaneleka kwenkqubo.Isisombululo se-Phosphate buffer (1.36g potassium dihydrogen phosphate, i-ultrasonic echithwe kwi-1L yamanzi, i-phosphoric acid elungiswe kwi-PH 3.0) isetyenziswe njengesigaba esihambayo A. I-Acetonitrile yisigaba esihambayo B, kwaye i-gradient elution yenziwa ngokuhambelana netafile elandelayo:
Ixesha (min) Isigaba esihambayo A isigaba B
0 80 20
15 80 20
30 50 50
45 50 50
Ubude bokubona ubude be-254 nm.Umlinganiselo wokuhamba wawuyi-1.0 ml / min.Inani leeplati zeethiyori alikho ngaphantsi kwe-2000 ngokwencopho ye-4-Amino-5-Chloro-2,3-Dihydrobenzofuran-7-Carboxylic Acid
Incopho ye-furanoformic acid ayikho ngaphantsi kwe-2000.
Indlela yokumisela:
Thatha i-10mg yemveliso yovavanyo, uyilinganise ngokuchanekileyo, uyibeke kwi-A 10ml ibhotile, yichithe i-ultrasonic ngesigaba esihambayo A-mobile isigaba B (70:30) njenge-solvent, yihlambulule kwisikali, xubha kakuhle, kwaye ulungiselele isisombululo kunye noxinzelelo lwe-1mg / ml.I-20 l yokuchaneka yafakwa kwi-chromatograph yolwelo, kwaye i-chromatogram yabhalwa.Incopho ephambili yokucoceka yayingekho ngaphantsi kwe-98.0% ngokwendlela yokulinganisa indawo ephezulu
Ikholamu: I-Dionex Acclaim C18, 4.6 * 250mm, 5um
Ubushushu bekholamu: 40℃
Izinga lokuhamba: 1.0ml / min
Ukubonwa kobude: 254nm
Ubungakanani besampuli: 10μL
Ukuthenga njani?Nceda uqhagamshelaneDr. Alvin Huang: sales@ruifuchem.com or alvin@ruifuchem.com
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I-4-Amino-5-Chloro-2,3-Dihydrobenzofuran-7-Carboxylic Acid (CAS: 123654-26-2), ingasetyenziselwa njengendawo ephakathi kwi-synthesis yePrucalopride Succinate (CAS: 179474-85-2), i-agonist ekhethiweyo ye-5-HT4 ye-receptor esetyenziswa ngokufanelekileyo kwi-constipation engapheliyo.I-Prucalopride Succinate, i-dihydrobenzofurancarboxamide yeklasi yokuqala, i-serotonin ekhethiweyo (i-5- HT4) i-receptor agonist.Ichiza, elithengiswe phantsi kwegama lebrendi i-Resolor®, linomsebenzi we-enterookinetic kwaye laphuhliswa yifemu esekwe eBelgian yamayeza iMovetis.I-Prucalopride iguqula iipateni ze-colonic motility nge-serotonin 5-HT4 i-receptor stimulation, ibangela amandla aphakathi okuqhubela phambili kwi-defecation.
