I-2-Cyanophenylboronic Acid 1,3-Propanediol Ester CAS 172732-52-4 Perampanel Intermediate Purity>99.0% (HPLC)
I-Shanghai Ruifu Chemical Co., Ltd. ngumenzi ohamba phambili we-2-Cyanophenylboronic Acid 1,3-Propanediol Ester (CAS: 172732-52-4) enomgangatho ophezulu, ophakathi kwePerampanel (CAS: 380917-97-5).I-Ruifu Chemical inokubonelela ngenkonzo yehlabathi jikelele, ixabiso elikhuphisanayo, inkonzo egqwesileyo, encinci kunye nezixa ezininzi ezikhoyo.Thenga iPerampanel intermediates, Please contact: alvin@ruifuchem.com
| Igama leMchiza | I-2-Cyanophenylboronic Acid 1,3-Propanediol Ester |
| Izithethantonye | I-2-Cyanobenzeneboronic Acid 1,3-Propanediol Ester;2-(1,3,2-Dioxaborinan-2-yl) benzonitrile |
| Inombolo yeCAS | 172732-52-4 |
| Ubume beStokhwe | Kwi-Stock, iMveliso yoMveliso ukuya kwiiToni |
| Ifomula yeemolekyuli | I-C10H10BNO2 |
| Ubunzima beMolekyuli | 187.01 |
| Indawo yokunyibilika | 46.0~51.0℃ (ilayiti.) |
| Ukuxinana | 1.13±0.10 g/cm3 |
| Ukunyibilika | Inyibilika kwiMethanol |
| Uzinzo | Hygroscopic |
| Uphawu | Ruifu Chemical |
| Into | Iinkcukacha |
| Imbonakalo | Umgubo oMhlophe ukuya kokuKhanyayo ukuya kwiCrystal |
| Ubunyulu / Indlela yokuHlalutya | >99.0% (HPLC) |
| Ilahleko ekomisweni | <0.50% |
| Intsalela kwi-Ignition | <0.20% |
| Ukungacoceki Okukodwa | <0.50% |
| Ukungcola ngokupheleleyo | <1.00% |
| Iintsimbi ezinzima (njenge Pb) | <20ppm |
| Umgangatho woVavanyo | Umgangatho woShishino |
| Ukusetyenziswa | Umbindi wePerampanel (CAS: 380917-97-5) |
Iphakheji: Ibhotile, ingxowa yefoyile yeAluminiyam, 25kg/Igubu lekhadibhodi, okanye ngokwemfuno yomthengi.
Imeko yoGcino:Gcina kwizikhongozeli ezivaliweyo kwindawo epholileyo neyomileyo;Khusela ukukhanya kunye nokufuma.
Iimpawu zeHazard Xi - Irritant
Iikhowudi zoMngcipheko
I-R20/21/22 - Iyingozi ngokuphefumla, xa udibana nolusu naxa uginyiwe.
R36/37/38 - Ukucaphukisa emehlweni, inkqubo yokuphefumla kunye nolusu.
Inkcazelo yoKhuseleko
S26 - Xa udibana namehlo, hlambulula ngokukhawuleza ngamanzi amaninzi kwaye ufune iingcebiso zonyango.
S36/37/39 - Nxiba iimpahla ezifanelekileyo zokukhusela, iiglavu kunye nokukhusela amehlo / ubuso.
Ii-ID ze-UN 3439
WGK eJamani 3
Inombolo ye-TSCA
I-Hazard Note irritant
I-2-Cyanophenylboronic Acid 1,3-Propanediol Ester (CAS: 172732-52-4) isetyenziswe kwi-synthesis yePerampanel (i-CAS: 380917-97-5), umchasi we-AMPA we-receptor.IPerampanel (inikwe ilayisenisi ngo-2012) sisizukulwana sesithathu se-AED eyaziwa ngegama lokuthengisa le-Fycompa® (Eisai, Hatfield) e-UK kunye ne-Banzel® (Eisai, Hatfield) e-USA.Ngo-Oktobha ka-2012, i-US FDA yavuma i-perampanel yonyango lokubanjwa kancinci kwizigulane ezine-epileptic ezineminyaka eyi-12 ubuncinane.IPerampanel ngumchasi wokuqala we-AMPA we-receptor ukufumana imvume ye-FDA njenge-AED.I-AMPA glutamate receptors ifumaneka ngokuyintloko kwi-postsynaptic neurons kwingqondo.Njengomchasi okhethiweyo, ongenakukhuphisana we-AMPA, i-parampanel ikhusela ukuvulwa kwesiteshi se-ion kwaye iyanciphisa ukusasazwa kwezinto ezinokwenzeka.I-Perampanel yamkelwa yi-EMA yaseYurophu kunye ne-US FDA ngoJulayi no-Oktobha 2012 ngokulandelelanayo, isetyenziselwa unyango lwe-adjuvant lwezigulane ezinokubanjwa okuyingxenye ngaphezu kweminyaka eyi-12 ubudala kunye okanye ngaphandle kwe-secondary systemic seizures.NgoJuni 22, i-2015, u-Eisai ubhengeze ukuba i-US FDA ivume ukwandiswa kwesibonakaliso se-Pirenparanide hydrate (Fycompa) njengonyango lwe-adjuvant kwi-primary comprehensive tonic-clonic seizures kwizigulane ezine-12 ubudala nangaphezulu.
