5-(2R)-2-Oxiranyl-8-Benzyloxy-2(1H)-Quinolinone CAS 173140-90-4 Indacaterol Maleate Intermediate Purity>98.0% (HPLC)
Unikezelo lwezoRhwebo lwe-Indacaterol Maleate (CAS: 753498-25-8) abaPhakathi abaNxulumeneyo:
5,6-Diethyl-2,3-dihydro-1H-inden-2-amine hydrochloride CAS: 312753-53-0
I-8-Benzyloxy-5-(2-Bromoacetyl)-2-Hydroxyquinoline CAS: 100331-89-3
5-(2R)-2-Oxiranyl-8-benzyloxy-2(1H)-quinolinone CAS: 173140-90-4
| Igama leMchiza | 5-(2R)-2-Oxiranyl-8-Benzyloxy-2(1H)-Quinolinone |
| Izithethantonye | 8-Benzoxy-5-(R)-Oxiranyl-1H-Quinolin-2-Enye |
| Inombolo yeCAS | 173140-90-4 |
| Inombolo yeCAT | RF-PI127 |
| Ubume beStokhwe | Kwi-Stock, iMveliso yeMveliso ukuya kumakhulu eeKilogram |
| Ifomula yeemolekyuli | C18H15NO3 |
| Ubunzima beMolekyuli | 293.31 |
| Uphawu | Ruifu Chemical |
| Into | Iinkcukacha |
| Imbonakalo | Mthubi oMthubi ukuya kumgubo oMhlophe-Olupheleyo |
| Ubunyulu / Indlela yokuHlalutya | ≥98.0% (HPLC) |
| Ukufuma (KF) | ≤1.0% |
| Ukujikeleziswa okuthe ngqo | -20.0° ~ -26.0° (C=1 DMF) |
| Umgangatho woVavanyo | Umgangatho woShishino |
| Ukusetyenziswa | I-Indacaterol Maleate (CAS: 753498-25-8) Phakathi |
Iphakheji: Ibhotile, ingxowa yefoyile yeAluminiyam, igubu lekhadibhodi, 25kg/Igubu, okanye ngokwemfuno yomthengi.
Imeko yoGcino:Gcina kwizikhongozeli ezivaliweyo kwindawo epholileyo neyomileyo;Khusela ekukhanyeni, ukufuma kunye nokuhlaselwa zizinambuzane.
I-Shanghai Ruifu Chemical Co., Ltd. ngumenzi ohamba phambili kunye nomthengisi we-5- (2R) -2-Oxiranyl-8-benzyloxy-2 (1H) -quinolinone (CAS: 173140-90-4) kunye nomgangatho ophezulu.Yinto ephakathi ngokuqhelekileyo kwi-synthesis ye-Indacaterol Maleate (CAS: 753498-25-8).
I-Indacaterol Maleate (CAS: 753498-25-8) yinto entsha, i-ultra-long-acting, iqala ngokukhawuleza i-β (2) -adrenoceptor agonist kunye ne-bronchodilator.Isetyenziselwa unyango lwezifo ezingapheliyo ze-pulmonary (COPD) kunye ne-asthma.I-Arhente ye-European Medicines Agency (EMA) ivume i-indacaterol njengechiza kwi-2009 phantsi kwegama lokuthengisa i-Onbrez ngelixa e-United States i-Food and Drug Administration ivume phantsi kwegama lokuthengisa i-Arcapta kwi-2011. Ichiza lenziwa njengefom yetyuwa ye-malate.Kwakhona, i-indacaterol yi-molecule ye-chiral;nangona kunjalo, kuphela i-R-enantiomer ecocekileyo isasazwa.Kufuneka ithathwe kanye kuphela ngosuku, ngokungafaniyo nabakhuphisana nabo kwi-formoterol kunye ne-salmeterol.
