CAS 177036-94-1 Ubunyulu >99.0% (HPLC) API Factory High Purity Featured Image

I-CAS 177036-94-1 Ubunyulu > 99.0% (HPLC) I-API Factory High Purity

Inkcazelo emfutshane:

CAS: 177036-94-1

Ubunyulu: >99.0% (HPLC)

Imbonakalo: I-White okanye i-Off-White Powder

Unyango lwe-Pulmonary Arterial Hypertension (PAH)

Umgangatho ophezulu we-API, iMveliso yoRhwebo

E-Mail: alvin@ruifuchem.com

Thumela i-imeyile kuthi

Iinkcukacha zeMveliso

Iimveliso ezinxulumeneyo

Iithegi zeMveliso

Inkcazo:

Ubonelelo ngezoRhwebo (CAS: 177036-94-1) abaPhakathi abaNxulumeneyo:
CAS: 177036-94-1
I-Methyl 2-Hydroxy-3-Methoxy-3,3-Diphenylpropanoate CAS: 178306-47-3
I-2-Hydroxy-3-Methoxy-3,3-Diphenylpropanoic Acid CAS: 178306-51-9
(S)-2-Hydroxy-3-Methoxy-3,3-Diphenylpropionic Acid CAS: 178306-52-0
L-Proline Methyl Ester Hydrochlorid CAS: 2133-40-6
4,6-Dimethyl-2-(Methylsulfonyl)pyrimidine CAS: 35144-22-0

Iipropati zeMichiza:

Igama leMchiza	(S) -2-[(4,6-Dimethylpyrimidin-2-yl)oxy]-3-Methoxy-3,3-Diphenylpropionic Acid
Izithethantonye	(+-)-(2S)-2-((4,6-Dimethylpyrimidin-2-yl)oxy)-3-Methoxy-3,3-Diphenylpropanoic Acid
Inombolo yeCAS	177036-94-1
Ubume beStokhwe	Kwi-Stock, iMveliso yoMveliso ukuya kwiiToni
Ifomula yeemolekyuli	I-C22H22N2O4
Ubunzima beMolekyuli	378.43
Ukujikeleziswa okuthe ngqo [α]D20	+170.0 ° ukuya +176.0 ° (C=0.5, MeOH)
Indawo yokunyibilika	172.0~178.0℃(dec.)
Ukunyibilika	Inyibilika kakhulu kwiMethanol;Inyibilika kwi-Ethanol, i-acetone;Ayinyibilikiyo emanzini
Uphawu	Ruifu Chemical

Iinkcukacha:

Into	Iinkcukacha
Imbonakalo	Umgubo oMhlophe okanye oMhlophe
Ukuchongwa	I-HPLC;NMR;I-LC-MS
Izinto ezinxulumeneyo
Ukungacoceki komntu	≤0.50%
Ukungcola ngokupheleleyo	<1.00%
Ilahleko ekomisweni	≤0.50%
Intsalela kwi-Ignition	≤0.20%
Iintsimbi ezinzima	≤20ppm
Ubunyulu / Indlela yokuHlalutya	>99.0% (HPLC)
Umgangatho woVavanyo	Umgangatho woShishino
Ukusetyenziswa	AbaPhakathi bamayeza

Ukupakishwa kunye noGcino:

Iphakheji: Ibhotile, ingxowa yefoyile yeAluminiyam, 25kg/Igubu lekhadibhodi, okanye ngokwemfuno yomthengi

Imeko yoGcino:Gcina kwizikhongozeli ezivaliweyo kwindawo epholileyo neyomileyo;Khusela ukukhanya kunye nokufuma

Izinto eziluncedo:

FAQ:

Isicelo:

(CAS: 177036-94-1) APIngumchasi we-endothelin-A (ETA) okhethiweyo owaziswa kunyango lomlomo lwezigulane ezine-pulmonary arterial hypertension (PAH), ukuphucula umthamo wokuzilolonga kunye nokulibazisa ukonakala kweklinikhi.I-PAH isifo esinqabileyo semibhobho encinci ye-pulmonary ebonakaliswe ngokunyuka kwe-vascular kunye nokulungiswa kwakhona, okubangelwa ukunyuka okuqhubekayo kwi-pulmonary vascular resistance and pulmonary arterial pressure, kwaye ekugqibeleni, ukungaphumeleli kwe-ventricular kunye nokufa kwangaphambi kwexesha.Iimpawu zakwangoko ze-PAH ziquka ukuphelelwa ngumphefumlo ngokuthe ngcembe, ukudinwa, ukubetha kwentliziyo, ukudumba, nokuquleka.I-Endothelin-1 (ET-1), i-vasoconstrictor enamandla kunye ne-mitogen ye-muscle egudileyo, inegalelo eliphambili ekukhawuleziseni kwesi sifo, kwaye iziphumo zayo zixutywe ngokusetyenziswa kwe-ETA kunye ne-ETB receptors.NgoJuni ka-2007, i-FDA inike imvume (i-CAS: 177036-94-1) i-API yonyango lwe-PAH kanye ngosuku.