I-1-(3-Methoxypropyl) -4-Piperidinamine CAS 179474-79-4 Prucalopride Succinate Intermediate Purity>98.0% (GC)
I-Shanghai Ruifu Chemical Co., Ltd. ngumenzi ohamba phambili we-1- (3-Methoxypropyl) -4-Piperidinamine (CAS: 179474-79-4) enomgangatho ophezulu, ophakathi kwePrucalopride Succinate (CAS: 179474-85-2) .I-Ruifu Chemical inokubonelela ngenkonzo yehlabathi jikelele, ixabiso elikhuphisanayo, inkonzo egqwesileyo, encinci kunye nezixa ezininzi ezikhoyo.Thenga i-1-(3-Methoxypropyl)-4-Piperidinamine,Please contact: alvin@ruifuchem.com
| Igama leMchiza | I-1-(3-Methoxypropyl) -4-Piperidinamine |
| Izithethantonye | I-1-(3-Methoxypropyl) ipiperidin-4-Amine;4-Amino-1-(3-Methoxypropyl)piperidine;IPrucalopride Succinate Intermediate B;IPrucalopride ephakathi B;Ukungacoceki kwePrucalopride 17 |
| Ubume beStokhwe | Kwi-Stock, iMveliso yoRhwebo |
| Inombolo yeCAS | 179474-79-4 |
| Ifomula yeemolekyuli | I-C9H20N2O |
| Ubunzima beMolekyuli | 172.27 g/mol |
| Indawo yokubilisa | 249℃ |
| Indawo yokuflasha | 105℃ |
| Ukuxinana | 0.946 g/cm3 |
| I-COA kunye ne-MSDS | Iyafumaneka |
| Imvelaphi | Shanghai, China |
| Ukuhambisa ngenqanawe | Okuqhelekileyo |
| Udidi | Phakathi kwePrucalopride Succinate (CAS: 179474-85-2) |
| Uphawu | Ruifu Chemical |
| Izinto | ImiGangatho yokuHlola | Iziphumo |
| Imbonakalo | AbunaMbala ukuya kuLwelo oluKhanyayo | Ulwelo olungenambala |
| Amanzi nguKarl Fischer | <0.50% | 0.25% |
| Ukungacoceki Okukodwa | <0.50% | 0.11% |
| Ukungcola ngokupheleleyo | <2.00% | 0.70% |
| Ubunyulu / Indlela yokuHlalutya | >98.0% (GC) | 99.3% |
| I-1 H NMR Spectrum | Iyahambelana neSakhiwo | Iyahambelana |
| Ukuqukumbela | Imveliso ivavanyiwe kwaye iyahambelana neenkcukacha ezinikiweyo | |
Umqulu:Ibhotile, 25kg / Drum, okanye ngokwemfuno umthengi.
Imeko yoGcino:Gcina isikhongozeli sivalwe ngokuqinileyo kwaye usigcine kwindawo epholileyo, eyomileyo (2~8℃) kunye nendawo yokugcina impahla engena moya ikude kwizinto ezingahambelaniyo.Khusela ukukhanya kunye nokufuma.
Ukuhambisa ngenqanawe:Zisa kwihlabathi liphela ngomoya, ngeFedEx / DHL Express.Ukubonelela ngokukhawuleza nangokuthembekileyo.
Le mveliso yi-1-(3-Methoxypropyl) -4-Piperidinamine.Iqulethe i-C9H20N2O ayiyi kuba ngaphantsi kwe-98.0%, ibalwa ngesiseko se-anhydrous.
[Iinkcazelo ngeempawu: Le mveliso ayinambala ukuya kulwelo olutyheli olukhanyayo.
Thatha ubungakanani obufanelekileyo bamanzi ale mveliso, yongeza i-solvent (methanol), uyinyibilikise, uyimisele ngokwendlela yokumisela amanzi (Isihlomelo Ⅷ M, indlela yokuqala A), sebenzisa amathontsi ovavanyo lukaFisher ukumisela de isisombululo sitshintshe ukusuka ekukhanyeni okutyheli. kumdaka obomvu obonisa isiphelo, kwaye uqhube olunye uvavanyo olungenanto.Bala ngokwefomula ilandelayo: umthamo wamanzi akufanele udlule i-1.0%.
Isiqulatho sokufuma (%) = (AB) F/W×100%
Apho, A ngumthamo wolwelo lweFisher olusetyenziswe yimveliso yovavanyo (ml);
B ngumthamo wolwelo lovavanyo lukaFisher olusetyenziswe sisithuba esingenanto, ml;
F bubunzima besisombululo sovavanyo lukaFisher olulingana namanzi nge-1ml, mg;
W ubunzima bemveliso yovavanyo, mg
Ukungcola okukodwa
Ngokweemeko zokufumanisa kunye neendlela phantsi [kokumiselwa komxholo], i-chromatogram irekhodwe kwaye ixesha lokugcinwa ukusuka kwinqanaba eliphambili lalingama-3 amaxesha.Ukuba kukho incopho yokungcola kwisisombululo sovavanyo, ukungcola okukodwa akuyi kuba ngaphezulu kwe-0.5% kwaye isixa sabo bonke ukungcola asiyi kuba ngaphezu kwe-2.0% ngokwendlela yesiqhelo yendawo.
[Ukumiselwa komxholo] Ngokwendlela eshiyekileyo yokumisela isinyibilikisi (Isihlomelo Ⅷ P)
(6%) i-cyanopropyl phenyl - (94%) i-dimethylpolysiloxane (okanye i-polarity efanayo) njengekholamu ye-capillary engamanzi;
Indlela yokufudumala ecwangcisiweyo yenkqubo yesampuli ye-capillary column headspace kunye neemeko zechromatographic yegesi yasetyenziswa.Iqondo lokushisa lokuqala laliyi-100℃ ye-5min, kwaye iqondo lokushisa liphakanyiswe kwi-15℃ ngomzuzu ukuya kwi-250℃ nge-4min.Iqondo lobushushu lokungena laliyi-250℃, kwaye iqondo lobushushu besixhobo lalingama-280℃.Umlinganiselo wokuhamba wawuyi-4ml/min.Umlinganiselo we shunt ngu 8:1.
Ngokumalunga ne-0.6g yale mveliso ithathwe, ilinganiswe ngokuchanekileyo, ifakwe kwibhotile ye-10ml, ichithwe nge-methanol kwaye ihlanjululwe kwisikali, njengesisombululo semveliso yovavanyo.Isisombululo sesampulu satofwa nge-1μl ubuncinane amaxesha amabini alandelelanayo, ngokulandelelanayo.Indawo encopho yencopho eza kulinganiswa yamiselwa.Incopho ephambili yokucoceka yayingekho ngaphantsi kwe-98.0% ngokwendlela yokulinganisa indawo ephezulu.
Ukuthenga njani?Nceda uqhagamshelaneDr. Alvin Huang: sales@ruifuchem.com or alvin@ruifuchem.com
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Ezothutho?Nge-Express (FedEx, DHL), ngoMoya, ngoLwandle.
Amaxwebhu?Emva kwenkonzo yokuthengisa: I-COA, i-MOA, i-ROS, i-MSDS, njl.
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I-1-(3-Methoxypropyl) -4-Piperidinamine (CAS: 179474-79-4) i-synthetic intermediate esebenzayo kwi-synthesis yePrucalopride Succinate (CAS: 179474-85-2).I-Prucalopride yinto ekhethiweyo ye-5-HT4 ye-receptor agonist esetyenziswa ngokufanelekileyo kwi-constipation engapheliyo, kodwa okwangoku ayivunywanga kwi-US I-Prucalopride ivunyiwe kunyango lwe-constipation engapheliyo eYurophu.I-Prucalopride succinate, i-dihydrobenzofurancarboxamide yeklasi yokuqala, i-serotonin ekhethiweyo (i-5- HT4) i-receptor agonist.Ichiza, elithengiswe phantsi kwegama lebrendi i-Resolor®, linomsebenzi we-enterookinetic kwaye laphuhliswa yifemu esekwe eBelgian yamayeza iMovetis.I-Prucalopride iguqula iipateni ze-colonic motility nge-serotonin 5-HT4 i-receptor stimulation, ibangela amandla aphakathi okuqhubela phambili kwi-defecation.
