6,7-Bis(2-Methoxyethoxy)-4(3H)-Quinazolinone CAS 179688-29-0 Erlotinib Hydrochloride Intermediate Purity>99.0% (HPLC)
Umvelisi ohamba phambili kunye nomthengisi we-Erlotinib Hydrochloride Intermediates
I-Erlotinib Hydrochloride CAS 183319-69-9
3-Ethynylaniline CAS 54060-30-9
6,7-Bis (2-Methoxyethoxy)-3H-Quinazolin-4-enye CAS 179688-29-0
Please contact: alvin@ruifuchem.com
| Igama leMchiza | 6,7-Bis(2-Methoxyethoxy)-3H-Quinazolin-4-enye |
| Izithethantonye | 6,7-Bis(2-Methoxyethoxy)-4(3H)-Quinazolinone;I-6,7-Bis (2-Methoxyethoxy) -3,4-Dihydroquinazolin-4-enye;I-6,7-Bis (2-Methoxyethoxy) -4-Hydroxyquinazoline;I-6,7-Bis (2-Methoxyethoxy) -4-Quinazolinol;CP-380736 |
| Ukungcola | Ukungacoceki kwe-Erlotinib A;Ukungcola kwe-Erlotinib Lactam |
| Inombolo yeCAS | 179688-29-0 |
| Inombolo yeCAT | RF2685 |
| Ubume beStokhwe | Kwi-Stock, iMveliso yoMveliso ukuya kwiiToni |
| Ifomula yeemolekyuli | I-C14H18N2O5 |
| Ubunzima beMolekyuli | 294.31 |
| Indawo yokunyibilika | 190.0 ukuba 194.0℃ |
| Ukuxinana | 1.26±0.1 g/cm3 |
| Inovakalelo | Ubuthathaka bomoya |
| Uphawu | Ruifu Chemical |
| Into | Iinkcukacha |
| Imbonakalo | Umgubo oMhlophe okanye oMhlophe |
| Ubunyulu / Indlela yokuHlalutya | >99.0% (HPLC) |
| Indawo yokunyibilika | 190.0 ukuba 194.0℃ |
| Ilahleko ekomisweni | <0.50% |
| Intsalela kwi-Ignition | <0.20% |
| Ukungcola okuNxulumeneyo yi-HPLC | |
| Ukungacoceki komntu | <0.50% |
| Ukungcola ngokupheleleyo | <1.00% |
| Iintsimbi ezinzima | <10ppm |
| I-Infrared Spectrum | Iyahambelana neSakhiwo |
| Umgangatho woVavanyo | Umgangatho woShishino |
| Ukusetyenziswa | Phakathi kwe-Erlotinib Hydrochloride (CAS: 183319-69-9) |
Iphakheji: Ibhotile, ingxowa yefoyile yeAluminiyam, 25kg/Igubu lekhadibhodi, okanye ngokwemfuno yomthengi
Imeko yoGcino:Gcina kwizikhongozeli ezivaliweyo kwindawo epholileyo neyomileyo;Khusela ukukhanya kunye nokufuma
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I-6,7-Bis (2-Methoxyethoxy) -3H-Quinazolin-4-enye (i-CAS: 179688-29-0) iphakathi kwe-Erlotinib Hydrochloride (CAS: 183319-69-9).I-Erlotinib Hydrochlorate yi-molecule encinci ye-tyrosine kinase inhibitor esebenza ngokuguquguqukayo kwi-epidermal growth factor receptors, i-hydrochloride ye-erlotinib, ichiza elijoliswe kwi-molecular.I-US Food and Drug Administration (FDA) ivume i-erlotinib (i-Tarceva) idityaniswe ne-gemcitabine njengonyango lokuqala lomhlaza we-pancreatic kunye ne-metastatic.Isetyenziswa ikakhulu njengonyango lodidi lwesibini okanye lwesithathu kumhlaza wemiphunga okwinqanaba eliphezulu okanye i-metstatic non-small cell lung (NSCLC) kunye nonyango lomhlaza wepancreatic.Isetyenziswe njenge-tyrosine inhibitor yonyango lwe-NSCLC.Ikhompawundi encinci yemolekyuli i-Erlotinib Hydrochlorate yi-tyrosine kinase receptor inhibitor ethintela ukwanda kweeseli ze-tumor ngokuthintela i-phosphorylation, ibophelela kwi-intracellular catalytic domain ye-tyrosine kinase kukhuphiswano ne-ATP, ngaloo ndlela ivalela ukuhanjiswa komqondiso osezantsi kunye nokuthintela umsebenzi we-tumor cell ligand exhomekeke. HER-1/EGFR.
