3-Chloro-4-(3-Fluorobenzyloxy)aniline CAS 202197-26-0 Lapatinib Intermediate Purity>98.0% (HPLC)
I-Shanghai Ruifu Chemical Co., Ltd. ngumenzi ohamba phambili we-3-Chloro-4- (3-Fluorobenzyloxy) ianiline (i-CAS: 202197-26-0) enomgangatho ophezulu.I-Ruifu Chemical inokubonelela ngenkonzo yehlabathi jikelele, ixabiso elikhuphisanayo, inkonzo egqwesileyo, encinci kunye nezixa ezininzi ezikhoyo.Thenga iLapatinib Intermediates,Please contact: alvin@ruifuchem.com
Igama leMchiza | 3-Chloro-4-(3-Fluorobenzyloxy)aniline |
Izithethantonye | 3-Chloro-4-[(3-Fluorophenyl)methoxy]aniline;4-(3-Fluorobenzyloxy)-3-Chlorobenzenamine;ILapatinib ePhakathi B |
Ubume beStokhwe | Kwi-Stock, iMveliso yoRhwebo |
Inombolo yeCAS | 202197-26-0 |
Ifomula yeemolekyuli | I-C13H11ClFNO |
Ubunzima beMolekyuli | 251.69 g/mol |
Indawo yokunyibilika | 78.0 ukuba 82.0℃ |
Ukuxinana | 1.306±0.06 g/cm3 |
I-COA kunye ne-MSDS | Iyafumaneka |
Isampulu | Iyafumaneka |
Imvelaphi | Shanghai, China |
Uphawu | Ruifu Chemical |
Izinto | ImiGangatho yokuHlola | Iziphumo |
Imbonakalo | Umdaka ukuya kwiPowder emnyama | Iyahambelana |
Indawo yokunyibilika | 78.0 ukuba 82.0℃ | 80.7℃ |
Ilahleko ekomisweni | <1.00% | Iyahambelana |
Intsalela kwi-Ignition | <0.50% | Iyahambelana |
Ukungcola okuNxulumeneyo yi-HPLC | <2.00% | 0.64% |
Ubunyulu / Indlela yokuHlalutya | >98.0% (HPLC) | 99.36% |
I-1H NMR Spectrum | Ngokungqinelana noLwakhiwo | Iyahambelana |
Ukuqukumbela | Imveliso ivavanyiwe kwaye ihambelana neenkcukacha ezinikiweyo | |
Isicelo | Phakathi kweLapatinib / Lapatinib Ditosylate Monohydrate |
Umqulu:Ibhotile eFluorinated, iAluminium foil bag, 25kg/Cardboard Drum, okanye ngokwemfuno yomthengi.
Imeko yoGcino:Gcina isikhongozeli sivaliwe kwaye usigcine kwindawo epholileyo, eyomileyo nengena umoya kakuhle kude nezinto ezingahambelaniyo.Khusela ukukhanya kunye nokufuma.
Ukuhambisa ngenqanawe:Zisa kwihlabathi liphela ngomoya, ngeFedEx / DHL Express.Ukubonelela ngokukhawuleza nangokuthembekileyo.
Ukuthenga njani?Nceda uqhagamshelaneDr. Alvin Huang: sales@ruifuchem.com or alvin@ruifuchem.com
Amava Eminyaka Eli-15?Sineminyaka engaphezu kwe-15 yamava ekwenziweni nasekuthumeleni kumazwe angaphandle uluhlu olubanzi oluphezulu lwamayeza aphakathi okanye amachiza alungileyo.
Iimarike eziphambili?Thengisa kwimarike yasekhaya, eMntla Melika, eYurophu, eIndiya, eKorea, eJapan, eOstreliya, njl.
Iingenelo?Umgangatho ophezulu, ixabiso elifikelelekayo, iinkonzo zengcali kunye nenkxaso yobugcisa, ukuhanjiswa ngokukhawuleza.
UmgangathoIsiqinisekiso?Inkqubo yokulawula umgangatho ongqongqo.Izixhobo zobuchwephesha zokuhlalutya ziquka i-NMR, LC-MS, GC, HPLC, ICP-MS, UV, IR, OR, KF, ROI, LOD, MP, Clarity, Solubility, Microbial limit test, njl.
Iisampulu?Uninzi lweemveliso zibonelela ngeesampulu zasimahla zokuvavanya umgangatho, iindleko zokuthumela kufuneka zihlawulwe ngabathengi.
Factory Audit?Uphicotho-zincwadi lwasefektri wamkelekile.Nceda wenze idinga kwangaphambili.
MOQ?Akukho MOQ.Umyalelo omncinci wamkelekile.
Ixesha lokuzisa? Ukuba ngaphakathi kwesitokhwe, ukuhanjiswa kweentsuku ezintathu kuqinisekisiwe.
Ezothutho?Nge-Express (FedEx, DHL), ngoMoya, ngoLwandle.
Amaxwebhu?Emva kwenkonzo yokuthengisa: I-COA, i-MOA, i-ROS, i-MSDS, njl.
Udibaniso lweSiko?Inokubonelela ngeenkonzo zesiko lokudibanisa ukuze zilungele iimfuno zakho zophando.
Immimiselo yokuhlawula?I-invoyisi yeProforma iya kuthunyelwa kuqala emva kokuqinisekiswa kwe-odolo, efakwe kwiinkcukacha zethu zebhanki.Intlawulo nge-T / T (i-Telex Transfer), i-PayPal, i-Western Union, njl.
Ii-ID ze-UN 3077
Ikhowudi yeHS 2921420090
Udidi 9 lweengozi
Ukupakisha Iqela III
I-3-Chloro-4- (3-Fluorobenzyloxy) i-aniline (i-CAS: i-202197-26-0) iphakathi kwi-synthesis yeLapatinib / Lapatinib Ditosylate Monohydrate.
I-Lapatinib lichiza elijolise kumdlavuza webele ophuhliswe yi-British GlaxoSmithKline Co. I-Human ErbB i-receptors iyingxenye ye-I tyrosine kinase (TK) intsapho ye-receptor, kuquka i-ErbB1 (EGFR), i-ErbB2 (HER2), i-ErbB3 (HER3), kunye ne-ErbB4 (HER4) .I-ErbB-1 (EGFR) kunye ne-ErbB-2 (HER-2) i-receptors zihlala zigqithise okanye zitshintshwe ngenye indlela kwizigulane zomhlaza.I-Human epidermal growth factor receptor 2 (ErbB-2, HER-2) yaziwa ngokuba ngumntu oncogene enxulumene ngokusondeleyo nomhlaza webele.Ukubonakaliswa kwayo okuphezulu kumhlaza wamabele kuhlala kuxela kwangaphambili i-lymph node metastasis kunye nokwahlulahlulwa kwethumba elibi, kunye ne-prognosis embi.I-HER-2 yenye yeemolekyuli ekujoliswe kuzo kunyango oluthile lomhlaza wamabele.ILapatinib inokusebenza ngaxeshanye kuyo yomibini i-Her-1 Her-2.Iziphumo zebhayoloji zale ndlela zithintela ukwanda kunye nokukhula kweeseli zethumba zikhulu kakhulu kunokuba zisebenze kwithagethi enye.Indibaniselwano yeLapatinib kunye neCapecitabine isetyenziselwa ukunyanga izigulane ezinomhlaza webele ophezulu okanye we-metastatic ngokugqithiswa kwe-epidermal receptor2 yabantu, esele iphathwe nge-anthracyclines, i-paclitaxel, kunye ne-trastuzumab.Ulingo lwezonyango lubonise ukuba iLapatinib ikwaphatha ngokukuko izigulane zomhlaza zohlobo lwe-HER2 ezinokumelana neHerceptin.
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