Vardenafil Intermediate CAS 224789-21-3 Ubunyulu > 99.0% (HPLC)
I-Shanghai Ruifu Chemical Co., Ltd. ngumenzi okhokelayo we-2-(2-Ethoxyphenyl)-5-Methyl-7-Propylimidazo[5,1-F][1,2,4]triazin-4(3H)-enye (I-CAS: 224789-21-3) enomgangatho ophezulu, ophakathi kweVardenafil.I-Ruifu Chemical inokubonelela ngenkonzo yehlabathi jikelele, ixabiso elikhuphisanayo, inkonzo egqwesileyo, encinci kunye nezixa ezininzi ezikhoyo.Thenga i-Vardenafil Intermediates,Please contact: alvin@ruifuchem.com
| Igama leMchiza | 2-(2-Ethoxyphenyl)-5-Methyl-7-Propylimidazo[5,1-F][1,2,4]triazin-4(3H)-enye |
| Izithethantonye | Ukungcola kweVardenafil Dessulfonyl;I-2-(2-Ethoxyphenyl)-5-Methyl-7-Propyl-3H-Imidazo[5,1-F][1,2,4]triazin-4-enye;I-Vardenafil Propyl Imidazotriazinone Ukungcola;Vardenafil Related Compound 1 |
| Ubume beStokhwe | KwiSitokhwe, Umthamo weMveliso iiToni ezi-2 ngenyanga |
| Inombolo yeCAS | 224789-21-3 |
| Ifomula yeemolekyuli | I-C17H20N4O2 |
| Ubunzima beMolekyuli | 312.37 g/mol |
| Indawo yokunyibilika | 142.0 ~ 148.0℃ |
| Ukuxinana | 1.26±0.10 g/cm3 |
| Ugcino Lwexesha elide | Indawo epholileyo neyomileyo (2~8℃) |
| I-COA kunye ne-MSDS | Iyafumaneka |
| Imvelaphi | Shanghai, China |
| Uphawu | Ruifu Chemical |
| Izinto | Iinkcukacha | Iziphumo |
| Imbonakalo | Okumhlophe-kuMhlophe ukuya kwiPoda eLuthulu | I-Off-White Powder |
| Indawo yokunyibilika | 142.0 ~ 148.0℃ | 146.0 ~ 147.0℃ |
| Ilahleko ekomisweni | <1.00% (102℃, 3h) | 0.23% |
| Iintsimbi ezinzima (Pb) | ≤20ppm | <20ppm |
| Ubunyulu / Indlela yokuHlalutya | >99.0% (HPLC) | 99.79% |
| I-1H NMR Spectrum | Ngokungqinelana noLwakhiwo | Iyahambelana |
| Ukuqukumbela | Imveliso ivavanyiwe kwaye ihambelana neenkcukacha ezinikiweyo | |
| Isicelo | Phakathi kweVardenafil / Vardenafil Hydrochloride | |
Umqulu:Ibhotile, ingxowa yefoyile yeAluminiyam, 25kg/Igubu lekhadibhodi, okanye ngokwemfuno yomthengi.
Imeko yoGcino:Gcina isikhongozeli sivalwe ngokuqinileyo kwaye usigcine kwindawo epholileyo, eyomileyo (2~8℃) kunye nendawo yokugcina impahla engena moya ikude kwizinto ezingahambelaniyo.Khusela ekukhanyeni kwelanga kunye nokufuma.
Ukuhambisa ngenqanawe:Zisa kwihlabathi liphela ngomoya, ngeFedEx / DHL Express.Ukubonelela ngokukhawuleza nangokuthembekileyo.
1. Imbonakalo: Beka isampulu kwiphepha elimhlophe kwaye ujonge inkangeleko, off-mhlophe ukuya kumgubo omthubi.
2. Uhlalutyo:
2.1 Ukumiselwa kwendawo enyibilikayo ngokomthetho (i-Chinese Pharmacopoeia 2010 Edition II Isihlomelo ⅥC) Indawo yokunyibilika yi-142.0~148.0℃.
2.2 Ilahleko ekomisweni: Ukumiselwa ngokomthetho (Isihlomelo ⅧL, iCandelo II, uHlelo luka-2010 lwe-Chinese Pharmacopoeia).Ukuchaneka kobunzima bexabiso elifanelekileyo le mveliso, yome kwi-102 ℃ kwiiyure ze-3, ukulahleka kwesisindo akuyi kuba ngaphezu kwe-1.00%.
2.3 Isinyithi esinzima: Ukumiselwa ngokomthetho (People's Republic of China Pharmacopoeia 2010 Edition, Part II Appendix ⅧH) Ukumiselwa ngendlela yesibini.
Ukuchaneka ubunzima be-1.0g yemveliso yovavanyo, ukutshisa ngokukhawuleza kude kube yi-carbonized ngokupheleleyo, ipholile, yongeza i-0.5-1.0ml sulfuric acid, yenza ukuba ifumile, ishushu kwiqondo lokushisa eliphantsi kude kube yilapho i-asidi ye-sulfuric iphelile, yongeza i-0.5ml nitric acid, i-steam yomile, de kube umphunga we-nitrogen oxide uphelile, upholile, ushushu kwi-500-600 ℃ ukuba i-carbonized ngokupheleleyo, ipholile, yongeza i-2ml i-hydrochloric acid, Emva kokumisa kwindawo yokuhlambela amanzi, yongeza i-15ml yamanzi, yehla isisombululo sovavanyo lwe-ammonia de ibe yinto engathathi hlangothi kwisalathisi se-phenolphthalein. isisombululo, yongeza i-2ml i-acetate buffer (ph3.5), kunye nobushushu obuncinci buyinyibilike, yihambise kwi-tube ye-Nachner colorimetric, kwaye udibanise kwi-25ml ngamanzi.Thatha enye i-reagent yokulungiselela isisombululo sokuvavanya, kwaye uyifake kwisitya se-porcelain, yongeza i-2ml ye-acetate buffer (PH3.5) kunye ne-15ml yamanzi ekutshiseni kancinci Emva kokuchithwa, hambisa i-Nath colorimetric tube, yongeza inani elithile lesisombululo esiqhelekileyo sokukhokelela, kwaye emva koko uhlambulule ngamanzi ukuya kwi-25ml.Uvavanyo lwe-colorimetric lwenziwa phakathi kwesisombululo sovavanyo kunye nesisombululo esiqhelekileyo sokufumana.Ukulungiswa kwesisombululo esisemgangathweni ngokwe (People's Republic of China Pharmacopoeia 2010 edition II Isihlomelo Ⅷ indlela yokuvavanya isinyithi esinzima) indlela yokuqala.Isinyithi esinzima akufuneki sibe ngaphezu kweengxenye ezingama-20 kwisigidi ngasinye.
3. Ubunyulu: Ngokokusebenza okuphezulu kwechromatography yolwelo, emiselwe ngokomthetho (Chinese Pharmacopoeia 2010 edition II Appendix VD).
Iimeko zeChromatographic:
Ikholamu: C18, 200mm×4.6mm, 5μm;
Isigaba seselula: I-Phosphate buffer (ubunzima be-2.72g potassium dihydrogen phosphate, yongeza amanzi ukuze udibanise kwaye udibanise kwi-1000ml, lungisa i-pH = 3.5): i-acetonitrile: = 35:65;
Ukubona ubude bamaza: 254nm;
Izinga lokuhamba: 1.0ml / min.
Indlela yokumisela: Thatha malunga ne-30mg yale mveliso, yilinganise ngokuchanekileyo, yihlambulule kunye nesigaba esihambahambayo ukwenza uxinaniso malunga ne-0.3mg / ml, thatha i-20μl kwi-chromatograph yolwelo, urekhode ichromatogram.Ngokwendlela yokulinganisa indawo, ukucoceka akukho ngaphantsi kwe-99.0%.
Ukuthenga njani?Nceda uqhagamshelaneDr. Alvin Huang: sales@ruifuchem.com or alvin@ruifuchem.com
Amava Eminyaka Eli-15?Sineminyaka engaphezu kwe-15 yamava ekwenziweni nasekuthumeleni kumazwe angaphandle uluhlu olubanzi oluphezulu lwamayeza aphakathi okanye amachiza alungileyo.
Iimarike eziphambili?Thengisa kwimarike yasekhaya, eMntla Melika, eYurophu, eIndiya, eKorea, eJapan, eOstreliya, njl.
Iingenelo?Umgangatho ophezulu, ixabiso elifikelelekayo, iinkonzo zengcali kunye nenkxaso yobugcisa, ukuhanjiswa ngokukhawuleza.
UmgangathoIsiqinisekiso?Inkqubo yokulawula umgangatho ongqongqo.Izixhobo zobuchwephesha zokuhlalutya ziquka i-NMR, LC-MS, GC, HPLC, ICP-MS, UV, IR, OR, KF, ROI, LOD, MP, Clarity, Solubility, Microbial limit test, njl.
Iisampulu?Uninzi lweemveliso zibonelela ngeesampulu zasimahla zokuvavanya umgangatho, iindleko zokuthumela kufuneka zihlawulwe ngabathengi.
Factory Audit?Uphicotho-zincwadi lwasefektri wamkelekile.Nceda wenze idinga kwangaphambili.
MOQ?Akukho MOQ.Umyalelo omncinci wamkelekile.
Ixesha lokuzisa? Ukuba ngaphakathi kwesitokhwe, ukuhanjiswa kweentsuku ezintathu kuqinisekisiwe.
Ezothutho?Nge-Express (FedEx, DHL), ngoMoya, ngoLwandle.
Amaxwebhu?Emva kwenkonzo yokuthengisa: I-COA, i-MOA, i-ROS, i-MSDS, njl.
Udibaniso lweSiko?Inokubonelela ngeenkonzo zesiko lokudibanisa ukuze zilungele iimfuno zakho zophando.
Immimiselo yokuhlawula?I-invoyisi yeProforma iya kuthunyelwa kuqala emva kokuqinisekiswa kwe-odolo, efakwe kwiinkcukacha zethu zebhanki.Intlawulo nge-T / T (i-Telex Transfer), i-PayPal, i-Western Union, njl.
I-2-(2-Ethoxyphenyl)-5-Methyl-7-Propylimidazo[5,1-F][1,2,4]triazin-4(3H)-enye (CAS: 224789-21-3) yindawo ephakathi IVardenafil (CAS: 224785-90-4) / Vardenafil Hydrochloride (CAS: 224785-91-5).I-Vardenafil yi-PDE5 inhibitor entsha eqaliswe kunyango lomlomo lwe-erectile dysfunction yamadoda kwaye inokufana okuphawulekayo kwesakhiwo kunye ne-sildenafil (i-Viagra), eyayiyi-PDE5 inhibitor yokuqala eyaziswa kwi-1998 kwesi sibonakaliso.
I-Vardenafil yayiyi-arhente yesibini ukuba ithengiswe kwaye yayinenzuzo yokuba ixesha layo lokuqala alizange lincitshiswe ngokuthatha iyeza kwisisu esipheleleyo .Ngamaxesha e-30 anamandla njenge-inhibitor ye-PDE5 (ithetha i-IC50, i-3.9 nM) kune-sildenafil kunye namaxesha e-10 anamandla ngaphezu kwe-tadalafil, ngokukhetha okukhulu (> amaxesha angama-1,000) kwi-PDE5 yabantu kune-PDE2 yabantu, i-PDE3, kunye ne-PDE4 kunye ukhetho oluphakathi (> amaxesha angama-80) kwi-PDE1.I-PDE inhibitory selectivity kunye ne-in vitro kunye ne-vivo potency ye-PDE5 inhibitor vardenafil entsha.I-Vardenafil inqande ngokukodwa i-hydrolysis ye-cGMP nge-PDE5, kunye ne-IC50 ye-0.7 nM (sildenafil 6.6 nM).I-IC50 ye-vardenafil ye-PDE1 yayingu-180 nM, ye-PDE6 11 nM, kunye ne-PDE2, i-PDE3 kunye ne-PDE4 ngaphezu kwe-1,000 nM.
