ILapatinib ePhakathi CAS 231278-84-5 Ubunyulu >98.0% (HPLC)
Igama leMchiza | 5-[4-[3-Chloro-4-(3-Fluorobenzyloxy)anilino]-6-Quinazolinyl]furan-2-Carboxaldehyde |
Izithethantonye | ILapatinib ePhakathi 3;5-[4-[[3-Chloro-4-[(3-Fluorophenyl)methoxy]phenyl]amino]-6-Quinazolinyl]-2-Furancarboxaldehyde;5-[4-((3-Chloro-4-((3-Fluorobenzyl)oxy)phenyl)amino)quinazolin-6-yl]-2-Furaldehyde |
Inombolo yeCAS | 231278-84-5 |
Ubume beStokhwe | Kwi-Stock, iMveliso yoMveliso ukuya kwiiToni |
Ifomula yeemolekyuli | I-C26H17ClFN3O3 |
Ubunzima beMolekyuli | 473.90 |
Indawo yokunyibilika | 225.0 ukuba 235.0℃ |
Ukuxinana | 1.407±0.06 g/cm3 |
Refractive Index | 1.694 |
I-COA kunye ne-MSDS | Iyafumaneka |
Imvelaphi | Shanghai, China |
Uphawu | Ruifu Chemical |
Into | Iinkcukacha |
Imbonakalo | Umgubo oMthubi oMthubi ukuya kumthubi |
Ubunyulu / Indlela yokuHlalutya | >98.0% (HPLC) |
Indawo yokunyibilika | 225.0 ~ 235.0℃ |
Ilahleko ekomisweni | <1.00% |
Intsalela kwi-Ignition | <0.50% |
Ukungcola ngokupheleleyo | <2.00% |
Iintsimbi ezinzima (njenge Pb) | <20ppm |
Umgangatho woVavanyo | Umgangatho woShishino |
Ukusetyenziswa | I-API ephakathi (CAS 388082-77-7) |
Iphakheji: Ibhotile, ingxowa yefoyile yeAluminiyam, 25kg/Igubu lekhadibhodi, okanye ngokwemfuno yomthengi
Imeko yoGcino:Gcina kwizikhongozeli ezivaliweyo kwindawo epholileyo neyomileyo;Khusela ukukhanya kunye nokufuma
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5-[4-[3-Chloro-4-(3-Fluorobenzyloxy)anilino]-6-Quinazolinyl]furan-2-Carboxaldehyde (CAS: 231278-84-5) iphakathi kwe-API (CAS 388082-77-7) ).(i-CAS 388082-77-7) lichiza elijolise kumdlavuza webele ophuhliswe yi-British GlaxoSmithKline Co. I-tyrosine kinase inhibitor enokuthintela ngokufanelekileyo umsebenzi we-tyrosine kinase we-epidermal growth factor receptors 1 kunye ne-2 (ErbB1, ErbB2).Inokwenza ngokukodwa ngeendlela ezahlukeneyo, iqinisekisa ukuba iiseli zomhlaza wamabele azikwazi ukufumana iimpawu zokukhula.Ivimbela i-intracellular EGFR (ErbB-1) kunye ne-HER2 (ErbB-2) iisayithi ze-ATP, ukukhusela i-tumor cell phosphorylation kunye nokusebenza, ukuthintela izibonakaliso eziphantsi kwe-homogeneity kunye ne-heterogeneity ye-EGFR (ErbB-1) kunye ne-HER2 (ErbB-1) ukuncipha.
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