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Apixaban Intermediate CAS 27143-07-3 Ethyl Chloro[(4-Methoxyphenyl)hydrazono]acetate Purity ≥99.0% (HPLC)
I-Ruifu Chemical ngumthengisi ohamba phambili we-Ethyl Chloro [(4-Methoxyphenyl) hydrazono] i-acetate (i-CAS: 27143-07-3) enomgangatho ophezulu, ophakathi kwe-Apixaban (CAS: 503612-47-3).I-Ruifu inokubonelela ngenkonzo yehlabathi jikelele, ixabiso elikhuphisanayo, amanani amancinci kunye nesixa esikhulu esikhoyo.Thenga i-Apixaban intermediates, i-imeyile: alvin@ruifuchem.com
| Igama leMchiza | I-Ethyl Chloro[(4-Methoxyphenyl)hydrazono]acetate |
| Izithethantonye | I-Ethyl 2-Chloro-2-[2-(4-Methoxyphenyl)hydrazono]acetate;(Z)-Ethyl 2-Chloro-2-(2-(4-Methoxyphenyl)hydrazono)acetate;2-Chloro-2-[2-(4-Methoxyphenyl)hydrazinylidene];Apixaban-2;Ukungacoceki kwe-Apixaban 3 |
| Ubume beStokhwe | Kwi-Stock, iMveliso yoRhwebo |
| Inombolo yeCAS | 27143-07-3 |
| Ifomula yeemolekyuli | I-C11H13ClN2O3 |
| Ubunzima beMolekyuli | 256.69 g/mol |
| Indawo yokunyibilika | 94℃ |
| Ukuxinana | 1.23 |
| I-COA kunye ne-MSDS | Iyafumaneka |
| Imvelaphi | Shanghai, China |
| Udidi | Phakathi kwe-Apixaban (CAS: 503612-47-3) |
| Uphawu | Ruifu Chemical |
| Izinto | ImiGangatho yokuHlola | Iziphumo |
| Imbonakalo | Umgubo oMthubi oKhanyayo ukuya kumthubi | Iyahambelana |
| Ilahleko ekomisweni | <0.50% | 0.23% |
| Ubunyulu / Indlela yokuHlalutya | ≥99.0% (HPLC) | 99.3% |
| I-Infrared Spectrum | Iyahambelana neSakhiwo | Iyahambelana |
| I-1 H NMR Spectrum | Ngokungqinelana noLwakhiwo | Iyahambelana |
| Ukuqukumbela | Imveliso ivavanyiwe kwaye iyahambelana neenkcukacha ezinikiweyo | |
Umqulu:Ibhotile, ingxowa yefoyile yeAluminiyam, 25kg/Igubu lekhadibhodi, okanye ngokwemfuno yomthengi.
Imeko yoGcino:Gcina isikhongozeli sivalwe ngokuqinileyo kwaye usigcine kwindawo epholileyo, eyomileyo (2~8℃) kunye nendawo yokugcina impahla engena moya ikude kwizinto ezingahambelaniyo.Khusela ukukhanya kunye nokufuma.
Ukuhambisa ngenqanawe:Zisa kwihlabathi liphela ngomoya, ngeFedEx / DHL Express.Ukubonelela ngokukhawuleza nangokuthembekileyo.
Uluhlu lwezinyibilikisi ezisetyenziswa kwiMveliso
| Hayi. | Igama | Inombolo yeCAS. | Ifomula yeemolekyuli |
| 1 | I-Ethyl Acetate | CAS: 141-78-6 | C4H8O2 |
| 2 | Dichloromethane | CAS: 75-09-2 | I-CH2Cl2 |
| 3 | Utywala be-Ethyl | CAS: 64-17-5 | C2H5OH |
5.3.1 Imbonakalo: Kufuneka ibengumgubo otyheli okhanyayo ukuya kumgubo omthubi.Ngokubonakalayo, beka ubungakanani obaneleyo bemveliso yovavanyo (ngaphandle kobunzima) kwisitya sekristale esicocekileyo kwimvelaphi emhlophe (njengephepha elimhlophe) phantsi kokukhanya kwendalo.
5.3.2 Ukuchonga: I-1H-NMR inesakhiwo esifanayo nomgangatho.I-10 ~ 15mg yesampulu yalinganiswa kwityhubhu yemagnethi yenyukliya, kwaye i-0.5mL ye-deuterium DMSO yongezwa ukunyibilikisa ngokupheleleyo isampuli, kwaye emva koko yavavanywa ngesixhobo senyukliya semagnetic resonance engaphezu kwe-400MHz.
5.3.3 Ilahleko ekomisweni : Yenza umlinganiselo wesampula malunga ne-1.0g kwaye uyomise i-3h kwi-oven yokumisa kwi-85℃.Umsebenzi othile wokubala ukulahleka kwesisindo uya kwenziwa ngokwemiqathango ye-SOP-AP-QC-002-01 yokuQinisekisa ukomisa ukuLahla kobunzima.
5.3.4.1 Iimeko zeChromatographic:
Ii-reagents zovavanyo: 1) i-acetonitrile yechromatography 2) amanzi acocekileyo 3) i-phosphoric acid
Uluhlu: WondaCract ODS-2 4.6 * 250mm * 5um (8520-39993)
Isigaba seselula: A: Ukulinganisa ngokuchanekileyo i-1.0ml phosphoric acid kunye ne-1000ml yamanzi, i-filter ultrasonic degassing.
B: IAcetonitrile.
Inkqubo yegradient: le theyibhile ilandelayo
Ixesha elihambayo inqanaba A (%) Isigaba esiphathwayo B (%)
3 90 10
10 25 75
20 0 100
25 0 100
Umtshina: 210nm
Ubushushu bekholamu: 35℃
Isantya sokuhamba: 1.0ml / min
Ubungakanani besampulu: 5µl
5.3.4.2 Ukulungiswa kwesisombululo:
5.3.4.3 Diluent: iacetonitrile
5.3.4.4 Isinyibiliko esingenanto: idiluent iya kusetyenziswa njengesisombululo esingenanto.
5.3.4.5 Isisombululo semveliso yovavanyo: Yenza umlinganiselo wemveliso yovavanyo malunga ne-12.5mg kwibhotile ye-volumetric ye-25ml kwaye uyinyibilikise nge-diluent kwisikali.
5.3.4.6 Inkqubo yokusebenza: Emva kokuba isiseko sesixhobo sizinzile, i-injection enye ukuya kweyesibini yesisombululo esingenanto ihamba phambili, kwaye isisombululo semveliso yovavanyo sihlalutywa.Ichromatogram igcinwa kwaye ihlalutywe, incopho engenanto itsalwa, kwaye eyona ncopho iphambili yokucoceka kunye neziphumo zokungcola okukodwa kwichromatogram yemveliso yovavanyo zirekhodwa ngokwendlela yesiqhelo yendawo.Emva kohlalutyo, ichromatogram yashicilelwa.
Ukuthenga njani?Nceda uqhagamshelaneDr. Alvin Huang: sales@ruifuchem.com or alvin@ruifuchem.com
Amava Eminyaka Eli-15?Sineminyaka engaphezu kwe-15 yamava ekwenziweni nasekuthumeleni kumazwe angaphandle uluhlu olubanzi oluphezulu lwamayeza aphakathi okanye amachiza alungileyo.
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Ixesha lokuzisa? Ukuba ngaphakathi kwesitokhwe, ukuhanjiswa kweentsuku ezintathu kuqinisekisiwe.
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I-Ethyl Chloro [(4-Methoxyphenyl) hydrazono] i-acetate (i-CAS: 27143-07-3) isetyenziswe njengendawo ephakathi kwi-synthesis ye-Apixaban (CAS: 503612-47-3).I-Apixaban luhlobo olutsha lwe-oral factor Xa inhibitor ephuhliswe ngokudibeneyo yiBristol-Myers Squibb kunye nePfizer.Igama lokurhweba ngu-Erroto.Luhlobo olutsha lwe-anticoagulant yomlomo.Ngokuthintela i-coagulation factor Xa, i-apixaban inokuthintela ukuveliswa kwe-thrombin kunye ne-thrombosis.I-Apixaban yaphuhliswa yiBristal-Myers squibb Company.Ine-bioavailability elungileyo kunye nokukhetha okuphezulu.Yayibhalwe e-China kwi-2013. I-Apixaban ikhuselekile, ithuba lokusebenzisana kweziyobisi lincinci, kwaye kukho iindlela ezininzi zokuyiphelisa, ekulindeleke ukuba isetyenziswe kumaqela akhethekileyo aphethwe yisifo sesibindi okanye umonakalo wezintso.
![Apixaban Intermediate CAS 27143-07-3 Ethyl Chloro[(4-Methoxyphenyl)hydrazono]acetate Purity ≥99.0% (HPLC)](https://www.ruifuchemical.com/uploads/Apixaban-Intermediate-CAS-490-46-0-Factory-Shanghai-Ruifu-Chemical-Co.-Ltd.-www.ruifuchem.com_-300x300.jpg)
