English
Ibrutinib Intermediate CAS 330792-70-6 Ubunyulu > 98.0% (HPLC) Umfanekiso obonakalayo
  • Ibrutinib Intermediate CAS 330792-70-6 Ubunyulu > 98.0% (HPLC)

Ibrutinib Intermediate CAS 330792-70-6 Ubunyulu > 98.0% (HPLC)

Inkcazelo emfutshane:

5-Amino-3-(4-Phenoxyphenyl)-1H-Pyrazole-4-Carbonitrile

CAS: 330792-70-6

Ubunyulu: >98.0% (HPLC)

Imbonakalo: Okumhlophe-kuMhlophe ukuya kwiPowder emthubi eKhanyayo

Umbindi we-Ibrutinib (CAS: 936563-96-1) 

Qhagamshelana: UGqr. Alvin Huang

Iselula/Wechat/WhatsApp: +86-15026746401

E-Mail: alvin@ruifuchem.com


Iinkcukacha zeMveliso

Iimveliso ezinxulumeneyo

Iithegi zeMveliso

Abaphakathi be-Ibrutinib:

Ibrutinib I-CAS 936563-96-1
3-Hydroxypiperidine I-CAS 6859-99-0
I-1-Boc-3-Hydroxypiperidine I-CAS 85275-45-2
(S) -1-Boc-3-Hydroxypiperidine I-CAS 143900-44-1
I-4-Phenoxybenzoic Acid I-CAS 2215-77-2
I-4-Phenoxyphenylboronic Acid I-CAS 51067-38-0
I-4-Aminopyrazolo[3,4-d] pyrimidine I-CAS 2380-63-4
4-Amino-3-Iodo-1H-Pyrazolo[3,4-d]pyrimidine I-CAS 151266-23-8
Ibrutinib Deacryloylpiperidine I-CAS 330786-24-8
5-Amino-3-(4-Phenoxyphenyl)-1H-Pyrazole-4-Carbonitrile I-CAS 330792-70-6

Iipropati zeMichiza:

Igama leMchiza 5-Amino-3-(4-Phenoxyphenyl)-1H-Pyrazole-4-Carbonitrile
Izithethantonye Ibrutinib ePhakathi N-3;3-Amino-5-(4-Phenoxyphenyl)pyrazole-4-Carbonitrile;3-Amino-4-Cyano-5-(4-Phenoxyphenyl)pyrazole;5-Amino-3-(4-Phenoxyphenyl)-1H-Pyrazole-4-Carbonitrile
Inombolo yeCAS 330792-70-6
Ubume beStokhwe Kwi-Stock, iMveliso yoMveliso ukuya kwiiToni
Ifomula yeemolekyuli I-C16H12N4O
Ubunzima beMolekyuli 276.29
Ukuxinana 1.37±0.10 g/cm3
I-COA kunye ne-MSDS Iyafumaneka
Imvelaphi Shanghai, China
Uphawu Ruifu Chemical

Iinkcukacha:

Into Iinkcukacha
Imbonakalo I-Off-White ukuya kwiPowder eKhanyayo etyheli
Ubunyulu / Indlela yokuHlalutya >98.0% (HPLC)
Ilahleko ekomisweni <1.00%
Intsalela kwi-Ignition <0.50%
Ukungcola ngokupheleleyo <2.00%
Iintsimbi ezinzima (njenge Pb) <20ppm
I-1 H NMR Spectrum Ngokungqinelana noLwakhiwo
Umgangatho woVavanyo Umgangatho woShishino
Ukusetyenziswa Umbindi we-Ibrutinib (CAS: 936563-96-1)

Ukupakishwa kunye noGcino:

Iphakheji: Ibhotile, ingxowa yefoyile yeAluminiyam, 25kg/Igubu lekhadibhodi, okanye ngokwemfuno yomthengi.

Imeko yoGcino:Gcina kwizikhongozeli ezivaliweyo kwindawo epholileyo neyomileyo;Khusela ukukhanya kunye nokufuma.

Izinto eziluncedo:

1

FAQ:

www.ruifuchem.com

330792-70-6 - Isicelo:

I-5-Amino-3- (4-Phenoxyphenyl) -1H-Pyrazole-4-Carbonitrile (CAS: 330792-70-6) iphakathi kwe-Ibrutinib (CAS: 936563-96-1).I-Ibrutinib ibonisa umphumo onamandla kunye nongenakuguquleka we-inhibitory kunye nokukhetha kwi-Btk umsebenzi we-enzymatic.Kwi-BCR indlela ye-DOHH2 ye-cell line, i-Ibrutinib inqanda i-autophosphorylation ye-Btk, i-phosphorylation ye-Btk's physiological substrate PLCγ, kunye ne-phosphorylation ye-downstream kinase, i-ERK kunye ne-IC50 ye-11 nM, i-29 nM kunye ne-13 nM ngokulandelanayo.I-Ibrutinib ibonisa i-dose exhomekeke kwi-dose kunye nexesha elixhomekeke kwi-cytotoxicity kwiiseli ezingapheliyo ze-lymphocytic leukemia (CLL).Ukongeza, i-Ibrutinib ibangela ukufa kweeseli ngokuxhomekeke ekusebenzeni kwendlela ye-caspase kwaye ichasene nokukwazi kweeseli ze-CLL ukuba zande emva kokubonakaliswa kwe-TLR.

Bhala umyalezo wakho apha kwaye uwuthumele kuthi