CAS 361442-04-8 Ucoceko >99.0% (HPLC) API Umfanekiso ofakiweyo

CAS 361442-04-8 Ubunyulu >99.0% (HPLC) API

Inkcazelo emfutshane:

Izithethantonye: BMS-477118;Onglyza

CAS: 361442-04-8

Ubunyulu: >99.0% (HPLC)

Imbonakalo: Umgubo oMhlophe

I-API, uMgangatho oPhezulu, iMveliso yoRhwebo

E-Mail: alvin@ruifuchem.com

Thumela i-imeyile kuthi

Iinkcukacha zeMveliso

Iimveliso ezinxulumeneyo

Iithegi zeMveliso

Inkcazo:

Ruifu Chemical Supply Related Intermediates
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Iipropati zeMichiza:

Izithethantonye	BMS-477118;Onglyza;(1S,3S,5S)-2-[(2S)-2-Amino-2-(3-Hydroxy-1-Adamantyl)acetyl]-2-Azabicyclo[3.1.0]hexane-3-Carbonitrile;(1S,3S,5S)-2-[(2S)-2-Amino-2-(3-Hydroxytricyclo [3.3.1.13,7]dec-1-yl)acetyl]-2-Azabicyclo[3.1.0]hexane -3-Carbonitrile
Inombolo yeCAS	361442-04-8
Inombolo yeCAT	RF-PI1991
Ubume beStokhwe	Kwi-Stock, iMveliso yoMveliso ukuya kwiiToni
Ifomula yeemolekyuli	I-C18H25N3O2
Ubunzima beMolekyuli	315.41
Uphawu	Ruifu Chemical

Iinkcukacha:

Into	Iinkcukacha
Imbonakalo	Umgubo oMhlophe
Ivumba	Uphawu
ukuchongwa	A: IR B: Ixesha lokugcinwa kweHPLC
Ubunyulu / Indlela yokuHlalutya	>99.0% (HPLC)
Ukucaca kwesisombululo saManzi	Okusekuhleni, okungenambala, akukho miba imisiweyo
Uhlalutyo lweSieve	100% Dlula i-80 Mesh
Indawo yokunyibilika	202.0~212.0℃
Ilahleko ekomisweni	<0.50%
Uthuthu lweSulfate	<0.20%
Ukujikeleziswa okuthe ngqo	+174.0 ° ~+186.0 °
Ukungacoceki Okukodwa	<0.50%
Ukungcola ngokupheleleyo	<1.00%
Iintsimbi ezinzima	<10ppm
IArsenic (As)	<2.0ppm
Khokela (Pb)	<1.0ppm
I-Cadmium (Cd)	<1.0ppm
Izinyibilikisi ezishiyekileyo	<100ppm
Intsalela yePesticide	Ibi
IMicrobiology
Ukubalwa kwePleti iyonke	<1000cfu/g
Igwele kunye noMngundo	<100cfu/g
E. Coli	Ibi
S. Aureus	Ibi
Salmonella	Ibi
Beka ubomi kwishelufa	Iinyanga ezingama-24 ukusuka kumhla wokuveliswa ukuba zigcinwe ngokufanelekileyo
Umgangatho woVavanyo	Umgangatho woShishino
Ukusetyenziswa	API;Uhlobo lwesi-2 seswekile iMellitus

Ukupakishwa kunye noGcino:

Iphakheji: Ibhotile, ingxowa yefoyile yeAluminiyam, 25kg/Igubu lekhadibhodi, okanye ngokwemfuno yomthengi

Imeko yoGcino:Gcina kwizikhongozeli ezivaliweyo kwindawo epholileyo neyomileyo;Khusela ukukhanya kunye nokufuma

Izinto eziluncedo:

FAQ:

Isicelo:

(BMS-477118) (i-CAS: 361442-04-8) yinto enamandla, ekhethiweyo, eguqulwayo, ekhuphisanayo kunye neyomlomo esebenzayo idipeptidyl peptidase-4 (DPP-4) (Ki = 0.6-1.3 nM) inhibitor.I-BMS-477118 ine-peotential yohlobo lwe-2 yophando lwe-diabetes mellitus.BMS-477118luhlobo lwesi-2 ichiza leswekile elinokuvuselela i-pancreas ukuba ivelise i-insulin eninzi emva kokutya.Ifikelelwe yintsebenziswano ye-AstraZeneca kunye ne-Bristol-Myers Squibb Inkampani kwaye ingeye-DPP-IV inhibitor.BMS-477118idlala indima ngokuthintela ukuthotywa kwe-GLP-l.I-GLP-I ziihomoni eziveliswa ngokwemvelo emathunjini emva kokutya.Inokulawula ukukhutshwa kwe-insulin kwaye iqinise ukusetyenziswa kwe-glucose kwizicubu ze-peripheral.Iyeza elilodwa le-BMS-477118 linokuphucula ulawulo lwe-glucose yegazi kunye neyeza elidibeneyo le-BMS-477118 kunye ne-Metformin, i-Sulfonylurea kunye ne-Thiazolidinediones inokuphucula umphumo wonyango.Ikhokelela kumngcipheko ophantsi we-hypoglycemia kunye neempendulo zayo ezingalunganga zifana ne-placebo, ebonisa ukunyamezela okungcono.NgoJulayi 31, 2009, BMS-477118 iipilisi (i-Onglyza), ichiza elitsha lohlobo lwe-2 yeswekile, uphando oludibeneyo kunye nokuphuhliswa kwe-AstraZeneca kunye ne-Bristol-Myers Squibb yavunywa yi-US FDA.Inokuthathwa kanye ngosuku ukunyanga uhlobo lwe-2 yeswekile edibeneyo nokulawula Ukutya kunye nokuzivocavoca.