I-5-(2-Pyridyl) -1,2-Dihydropyridin-2-enye i-CAS 381233-78-9 I-Perampanel ePhakathi Ucoceko>98.0% (HPLC)
I-Shanghai Ruifu Chemical Co., Ltd. ngumenzi ohamba phambili we-5-(2-Pyridyl) -1,2-Dihydropyridin-2-enye ([2,3'-Bipyridin] -6'(1'H)-enye) (I-CAS: 381233-78-9) enomgangatho ophezulu, ophakathi kwePerampanel (CAS: 380917-97-5).I-Ruifu Chemical inokubonelela ngenkonzo yehlabathi jikelele, ixabiso elikhuphisanayo, inkonzo egqwesileyo, encinci kunye nezixa ezininzi ezikhoyo.Thenga iPerampanel intermediates,Please contact: alvin@ruifuchem.com
| Igama leMchiza | 5-(2-Pyridyl) -1,2-Dihydropyridin-2-enye |
| Izithethantonye | [2,3'-Bipyridin]-6'(1'H) -enye;5-(Pyridin-2-yl)pyridin-2(1H)-enye;5-(Pyridin-2-yl)-2(1H)-Pyridone;5-(2-Pyridyl)pyridin-2(1H)-enye;5-Pyridin-2-yl-1H-Pyridin-2-enye;5-(Pyridin-2-yl) -1,2-Dihydropyridin-2-enye;Ukungacoceki kwePerampanel 1 |
| Ubume beStokhwe | Kwi-Stock, iMveliso yoRhwebo |
| Inombolo yeCAS | 381233-78-9 |
| Ifomula yeemolekyuli | I-C10H8N2O |
| Ubunzima beMolekyuli | 172.18 g/mol |
| Indawo yokunyibilika | 71.0 ~ 75.0℃ |
| Ukuxinana | 1.221±0.06 g/cm3 |
| I-COA kunye ne-MSDS | Iyafumaneka |
| Imvelaphi | Shanghai, China |
| Udidi | Umbindi wePerampanel (CAS: 380917-97-5) |
| Beka ubomi kwishelufa | Iinyanga ezingama-24 ukuba zigcinwe ngokufanelekileyo |
| Uphawu | Ruifu Chemical |
| Izinto | ImiGangatho yokuHlola | Iziphumo |
| Imbonakalo | Mhlophe ukuya Phantse uMhlophe | Umgubo oMhlophe |
| Ubunyulu / Indlela yokuHlalutya | >98.0% (HPLC) | 99.7% |
| Amanzi nguKarl Fischer | <1.00% | 0.58% |
| Ukungacoceki Okukodwa | <1.00% | Iyahambelana |
| Ukungcola ngokupheleleyo | <2.00% | 0.30% |
| I-1H NMR Spectrum | Ngokungqinelana noLwakhiwo | Iyahambelana |
| Ukuqukumbela | Imveliso ivavanyiwe kwaye ihambelana neenkcukacha ezinikiweyo | |
| Isicelo | Umbindi wePerampanel (CAS: 380917-97-5) | |
Umqulu:Ibhotile eFluorinated, iAluminium foil bag, 25kg/Cardboard Drum, okanye ngokwemfuno yomthengi.
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Iipropati: Mhlophe Ukuya Phantse Umgubo oMhlophe
Ukunyibilikisa: Tetrahydrofuran, Toluene, Ethylacetate, Ethanol, Methanol, tert-Butyl Methyl Ether, Petroleum Ether, n-Hexane, Dichloromethane
Jonga: Izinto eziyeleleneyo: Thatha le mveliso kwaye uyixube nge-diluent (amanzi esigaba esihambayo: i-methanol (50∶50)) ukwenza isisombululo esiqulethe malunga ne-0.5mg nge-1ml njengesisombululo semveliso yovavanyo.Ngokutsho chromatography ulwelo eliphezulu ukusebenza (Chinese Pharmacopoeia 2010 Edition II Isihlomelo Ⅴ D), ijeli silica (ZORBAX SB-C18 4.6 × 250mm,5m) yayisetyenziswa njengoko filler.Isigaba esihambayo A ibingamanzi, inqanaba elihambahambayo B ibiyimethanol, kwaye iwavelength yokubona yayiyi-254nm.Izinga lokuhamba laliyi-1.0ml / min kunye nobushushu bekholomu bubushushu begumbi.I-5μl yesisombululo sovavanyo yalinganiswa ngokuchanekileyo kwaye yatofwa kwichromatograph engamanzi ukurekhoda ichromatogram.Ngokwendlela yokulinganisa indawo, umxholo wale mveliso awukho ngaphantsi kwe-98%.Ukuba kukho iincopho zokungcola kwichromatogram yesisombululo semveliso yovavanyo, indawo yokungcola komntu ngamnye ayiyi kudlula i-1.0%, kwaye isixa sendawo yokungcola asiyi kudlula i-2.0%.
Ubumanzi: Thatha le mveliso, sebenzisa umvavanyi womswakama, ngokwendlela kaKarl Fischer (i-Chinese Pharmacopoeia 2010 edition II Isihlomelo Ⅷ M indlela yokuqala A) ukuzimisela, umthamo womswakama awuyi kudlula i-1.0%.
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5-(2-Pyridyl)-1,2-Dihydropyridin-2-enye ([2,3'-Bipyridin] -6'(1'H)-enye) (CAS: 381233-78-9), phakathi I-Perampanel (CAS: 380917-97-5).IPerampanel (inikwe ilayisenisi ngo-2012) sisizukulwana sesithathu se-AED eyaziwa ngegama lokuthengisa le-Fycompa® (Eisai, Hatfield) e-UK kunye ne-Banzel® (Eisai, Hatfield) e-USA.Unyango olongezelelweyo lwe-focal seizures kunye okanye ngaphandle kwe-generalization yesibini kunye ne-primary generalized tonic-clonic seizures.Ngo-Oktobha ka-2012, i-US FDA yavuma i-perampanel yonyango lokubanjwa kancinci kwizigulane ezine-epileptic ezineminyaka eyi-12 ubuncinane.IPerampanel ngumchasi wokuqala we-AMPA we-receptor ukufumana imvume ye-FDA njenge-AED.I-AMPA glutamate receptors ifumaneka ngokuyintloko kwi-postsynaptic neurons kwingqondo.Njengomchasi okhethiweyo, ongenakukhuphisana we-AMPA, i-parampanel ikhusela ukuvulwa kwesiteshi se-ion kwaye iyanciphisa ukusasazwa kwezinto ezinokwenzeka.
