Apixaban Intermediate CAS 503615-03-0 3-Morpholino-1- (4-Nitrophenyl)-5,6-Dihydropyridin-2 (1H)-enye Ukucoceka ≥99.0% (HPLC)
I-Ruifu Chemical ngumenzi ohamba phambili we-3-Morpholino-1- (4-Nitrophenyl) -5,6-Dihydropyridin-2 (1H)-enye (i-CAS: 503615-03-0) enomgangatho ophezulu.I-Ruifu Chemical inokubonelela ngenkonzo yehlabathi jikelele, ixabiso elikhuphisanayo, inkonzo egqwesileyo, encinci kunye nezixa ezininzi ezikhoyo.Thenga i-Apixaban intermediates,Please contact: alvin@ruifuchem.com
| Igama leMchiza | 3-Morpholino-1-(4-Nitrophenyl)-5,6-Dihydropyridin-2(1H)-enye |
| Izithethantonye | I-3-(4-Morpholinyl) -1-(4-Nitrophenyl) -5,6-Dihydro-2 (1H) -Pyridinone;I-5,6-Dihydro-3- (4-Morpholinyl) -1- (4-Nitrophenyl) -2 (1H) -Pyridinone;I-Apixaban ePhakathi 3;Ukungcola kwe-Apixaban 36;Inkqubo ye-Apixaban Ukungcola 1 |
| Ubume beStokhwe | Kwi-Stock, iMveliso yoRhwebo |
| Inombolo yeCAS | 503615-03-0 |
| Ifomula yeemolekyuli | I-C15H17N3O4 |
| Ubunzima beMolekyuli | 303.31 g/mol |
| Indawo yokunyibilika | 165.0 ~ 170.0℃ |
| Indawo yokubilisa | 506.5±50.0℃ |
| Ukuxinana | 1.357g/mL |
| I-COA kunye ne-MSDS | Iyafumaneka |
| Imvelaphi | Shanghai, China |
| Udidi | Phakathi kwe-Apixaban (CAS: 503612-47-3) |
| Uphawu | Ruifu Chemical |
| Izinto | ImiGangatho yokuHlola | Iziphumo |
| Imbonakalo | Umgubo oMthubi | Umgubo oMthubi |
| Indawo yokunyibilika | 165.0 ~ 170.0℃ | 167.0 ~ 170.0℃ |
| Ilahleko ekomisweni | ≤0.50% | 0.3% |
| Ukungacoceki komntu (Max.) | ≤0.50% | 0.3% |
| Ukungcola ngokupheleleyo | ≤1.00% | 0.6% |
| Ubunyulu / Indlela yokuHlalutya | ≥99.0% (HPLC) | 99.4% |
| I-1 H NMR Spectrum | Ngokungqinelana noLwakhiwo | Iyahambelana |
| LC/MS | Ngokungqinelana noLwakhiwo | Iyahambelana |
| Ukuqukumbela | Imveliso ivavanyiwe kwaye iyahambelana neenkcukacha ezinikiweyo | |
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I-3-Morpholino-1- (4-Nitrophenyl) -5,6-Dihydropyridin-2 (1H)-enye (i-CAS: 503615-03-0) yindawo ephakathi kwi-synthesis ye-Apixaban (CAS: 503612-47-3) .
I-Apixaban luhlobo olutsha lwe-oral Xa factor inhibitor ehlanganiswe nguBristol-Myers Squibb kunye nePfizer.Igama lokurhweba yi-Eratol, luhlobo olutsha lwe-anticoagulant yomlomo.Ngokuthintela i-coagulation factor Xa, i-Apixaban inokuthintela ukuveliswa kwe-thrombin kunye ne-thrombosis.
Ngo-Aprili 26, i-2007, uBristol-Myers Squibb wadibanisa izandla kunye noPfizer ukuvakalisa intsebenziswano ekuphuhliseni i-anticoagulant yomlomo entsha i-Apixaban ephethwe nguBristol-Myers Squibb njengenye indlela ephuculweyo ye-warfarin.Ngokwesivumelwano sentsebenziswano, iPfizer iya kuhlawula intlawulo yangaphambili ye-US $ 0.25 yezigidigidi kwiBristol-Myers Squibb ukuba ithwale i-60% yeendleko ezipheleleyo zophuhliso lwe-anticoagulant Apixaban (iya kuphunyezwa ukususela ngoJanuwari 1, 2007), ngelixa iBristol-Myers. I-squibb iya kuthwala i-40% eseleyo, ngaloo ndlela ifumana ilungelo lokuphuhlisa ngokudibeneyo kunye nokuthengisa ichiza.
NgoMeyi 2011, i-Apixaban yaba ngowokuqala ukuvuma ukukhuselwa kwe-venous thrombosis kwizigulane zabantu abadala ezithatha utyando olukhethiweyo lwe-hip okanye idolo kumazwe angama-27 e-EU, e-Iceland naseNorway.
Ngomhla we-20 kaNovemba, i-2012, iKhomishoni yaseYurophu yavuma i-Ererto (i-Apixaban) yokuthintela i-stroke kunye ne-systemic embolism kwizigulane zabantu abadala abane-non-valvular atrial fibrillation (NVAF) kunye neengozi enye okanye ngaphezulu.Emva koko, i-Canadian Food and Drug Administration, eJapan, kunye ne-US FDA ivume i-Ererto (i-Apixaban) yokuthintela ukubetha kunye ne-systemic embolism kwizigulane zabantu abadala abane-non-valvular atrial fibrillation (NVAF) kunye nenye okanye ngaphezulu kwezinto ezinobungozi.
Ngomhla we-12 ka-Apreli, i-2013, i-anticoagulant drug Eloto (ELIQUIS) (apixaban) ngokubambisana neBristol-Myers Squibb kunye nePfizer yabhengezwa ngokusemthethweni ukuba ibhalwe eChina.I-Ererto iyinoveli yomlomo we-Xa inhibitor yothintelo lwe-venous thromboembolism (VTE) kwizigulane zabantu abadala ezithatha indawo ekhethiweyo ye-hip okanye idolo.Uluhlu lwayo lunikeza ukhetho olutsha olukhuselekileyo nolusebenzayo lwe-anticoagulation yeklinikhi emva kotyando lwamathambo, kwaye izisa iindaba ezilungileyo kwizigulane zaseTshayina ezithatha indawo yokukhethwa kwe-hip / idolo.Izifundo zeklinikhi ziqinisekisile ukuba xa kuthelekiswa ne-40mg enoxaparin kanye ngosuku, amaxesha e-2 ngosuku ulawulo lomlomo lwe-Eratol (Apixaban) 2.5mg lusebenza ngakumbi ekukhuseleni i-venous thromboembolism emva kokuhlinzwa kwe-hip okanye idolo, kwaye ayinyusi umngcipheko wokuphuma kwegazi.
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