I-Apixaban i-Intermediate CAS 545445-44-1 Ubunyulu > 98.0% (HPLC)
I-Shanghai Ruifu Chemical Co., Ltd. ngumenzi ohamba phambili we-3-Morpholino-1- (4- (2-Oxopiperidin-1-yl) phenyl)-5,6-Dihydropyridin-2 (1H)-enye (CAS: 545445 -44-1) kunye nomgangatho ophezulu, ophakathi kwe-Apixaban (CAS: 503612-47-3).I-Ruifu Chemical inokubonelela ngenkonzo yehlabathi jikelele, ixabiso elikhuphisanayo, inkonzo egqwesileyo, encinci kunye nezixa ezininzi ezikhoyo.Thenga i-Apixaban Intermediates,Please contact: alvin@ruifuchem.com
| Igama leMchiza | 3-Morpholino-1-(4-(2-Oxopiperidin-1-yl)phenyl)-5,6-Dihydropyridin-2(1H)-enye |
| Izithethantonye | I-Apixaban ePhakathi 1;5,6-Dihydro-3- (4-Morpholinyl) -1-[4-(2-Oxo-1-Piperidinyl) phenyl] -2 (1H) -Pyridinone;5-Morpholin-4-yl-1-[4-(2-Oxopiperidin-1-yl) phenyl] -2,3-Dihydropyridin-6-enye;Ukungacoceki kweApixaban A |
| Ubume beStokhwe | Kwi-Stock, iMveliso yoRhwebo |
| Inombolo yeCAS | 545445-44-1 |
| Ifomula yeemolekyuli | I-C20H25N3O3 |
| Ubunzima beMolekyuli | 355.43 g/mol |
| Indawo yokunyibilika | >199℃(ngoDisemba) |
| Ukuxinana | 1.267 g/mL |
| I-COA kunye ne-MSDS | Iyafumaneka |
| Imvelaphi | Shanghai, China |
| Udidi | Phakathi kwe-Apixaban (CAS: 503612-47-3) |
| Uphawu | Ruifu Chemical |
| Izinto | Iinkcukacha | Iziphumo |
| Imbonakalo | Umgubo oMthubi oKhanya | Umgubo oMthubi oKhanya |
| Ilahleko ekomisweni | <0.50% | 0.16% |
| Intsalela kwi-Ignition | <0.20% | 0.07% |
| Ubunyulu / Indlela yokuHlalutya | >98.0% (Ummandla weHPLC) | 99.12% |
| Nakuphi na Ukungacoceki komntu | <0.50% | <0.50% |
| Ukungcola ngokupheleleyo | <2.00% | 0.88% |
| I-1H NMR Spectrum | Ngokungqinelana noLwakhiwo | Iyahambelana |
| I-LC-MS yokuchonga | Iyahambelana | Iyahambelana |
| Ukuqukumbela | Imveliso ivavanyiwe kwaye ihambelana neenkcukacha ezinikiweyo | |
| Isicelo | Phakathi kwe-Apixaban (CAS: 503612-47-3) | |
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I-3-Morpholino-1- (4-(2-Oxopiperidin-1-yl)phenyl)-5,6-Dihydropyridin-2 (1H)-enye (CAS: 545445-44-1) iphakathi kwe-Apixaban (CAS: 503612-47-3).
I-Apixaban luhlobo olutsha lwe-oral Xa factor inhibitor ehlanganiswe nguBristol-Myers Squibb kunye nePfizer.Igama lokurhweba yi-Eratol, luhlobo olutsha lwe-anticoagulant yomlomo.Ngokuthintela i-coagulation factor Xa, i-Apixaban inokuthintela ukuveliswa kwe-thrombin kunye ne-thrombosis.Ngo-Aprili 26, i-2007, uBristol-Myers Squibb wadibanisa izandla kunye noPfizer ukuvakalisa intsebenziswano ekuphuhliseni i-anticoagulant yomlomo entsha i-Apixaban ephethwe nguBristol-Myers Squibb njengenye indlela ephuculweyo yeWarfarin.NgoMeyi 2011, i-Apixaban yaba ngowokuqala ukuvuma ukukhuselwa kwe-venous thrombosis kwizigulane zabantu abadala ezithatha utyando olukhethiweyo lwe-hip okanye idolo kumazwe angama-27 e-EU, e-Iceland naseNorway.Ngomhla we-20 kaNovemba, i-2012, iKhomishoni yaseYurophu yavuma i-Ererto (i-Apixaban) yokuthintela i-stroke kunye ne-systemic embolism kwizigulane zabantu abadala abane-non-valvular atrial fibrillation (NVAF) kunye neengozi enye okanye ngaphezulu.Emva koko, i-Canadian Food and Drug Administration, eJapan, kunye ne-US FDA ivume i-Ererto (i-Apixaban) yokuthintela ukubetha kunye ne-systemic embolism kwizigulane zabantu abadala abane-non-valvular atrial fibrillation (NVAF) kunye nenye okanye ngaphezulu kwezinto ezinobungozi.Ngomhla we-12 ka-Apreli, i-2013, i-anticoagulant drug Eloto (ELIQUIS) (Apixaban) ngokubambisana neBristol-Myers Squibb kunye nePfizer yabhengezwa ngokusemthethweni ukuba ibhalwe eChina.
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