I-5-Amino-3- (Trifluoromethyl) picolinonitrile CAS 573762-62-6 Apalutamide Ucoceko oluPhakathi> 98.0% (HPLC)
I-Shanghai Ruifu Chemical Co., Ltd. ngumenzi ohamba phambili we-5-Amino-3- (Trifluoromethyl)picolinonitrile (CAS: 573762-62-6) enomgangatho ophezulu, ophakathi kwe-Apalutamide (CAS: 956104-40-8).I-Ruifu Chemical inokubonelela ngenkonzo yehlabathi jikelele, ixabiso elikhuphisanayo, inkonzo egqwesileyo, encinci kunye nezixa ezininzi ezikhoyo.Thenga iApalutamide Intermediates,Please contact: alvin@ruifuchem.com
| Igama leMchiza | 5-Amino-3-(Trifluoromethyl)picolinonitrile |
| Izithethantonye | 5-Amino-3-(Trifluoromethyl)pyridine-2-Carbonitrile;5-Amino-3-(Trifluoromethyl)2-Cyanopyridine;5-Amino-2-Cyano-3-(Trifluoromethyl)pyridine;Ukungacoceki kweApalutamide 10 |
| Ubume beStokhwe | Kwi-Stock, iMveliso yoRhwebo |
| Inombolo yeCAS | 573762-62-6 |
| Ifomula yeemolekyuli | C7H4F3N3 |
| Ubunzima beMolekyuli | 187.12 g/mol |
| Ukuxinana | 1.45±0.10 g/cm3 |
| I-COA kunye ne-MSDS | Iyafumaneka |
| Imvelaphi | Shanghai, China |
| IKlasi yeeNgozi | 6.1 |
| Iqela lokuPakisha | Ⅲ |
| Udidi | I-Intermediate ye-Apalutamide (CAS: 956104-40-8) |
| Uphawu | Ruifu Chemical |
| Izinto | ImiGangatho yokuHlola | Iziphumo |
| Imbonakalo | UkuKhanya okuMthubi ukuya kumthubi okuqinileyo | Iyahambelana |
| Amanzi nguKarl Fischer | <0.50% | 0.35% |
| Ubunyulu / Indlela yokuHlalutya | >98.0% (HPLC) | 99.03% |
| I-Infrared Spectrum | Ngokungqinelana noLwakhiwo | Iyahambelana |
| I-1H NMR Spectrum | Ngokungqinelana noLwakhiwo | Iyahambelana |
| Ukuqukumbela | Imveliso ivavanyiwe kwaye ihambelana neenkcukacha ezinikiweyo | |
| Isicelo | I-Intermediate ye-Apalutamide (CAS: 956104-40-8) | |
Umqulu:Ibhotile eFluorinated, iAluminium foil bag, 25kg/Cardboard Drum, okanye ngokwemfuno yomthengi.
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Ukuthenga njani?Nceda uqhagamshelaneDr. Alvin Huang: sales@ruifuchem.com or alvin@ruifuchem.com
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I-5-Amino-3- (i-Trifluoromethyl) picolinonitrile (i-CAS: 573762-62-6), i-pyridine heterocyclic organic compound, enokusetyenziswa njenge-pharmaceutical intermediates.I-5-Amino-3- (Trifluoromethyl) picolinonitrile iphakathi kwe-Apalutamide (CAS: 956104-40-8).I-Apalutamide sisizukulwana sesibini se-antiandrogen esetyenziswa kunyango lwe-prostate cancer.Ingumchasi onamandla we-androgen receptor enexabiso le-IC50 le-16 nM.Ibophelela i-androgen receptors, ngaloo ndlela inqanda ukuhanjiswa kwenyukliya, ukubopha i-DNA kunye nokusebenza kwe-transcriptional.I-Apalutamide ineenkqubo zonyango kwi-non-metastatic, i-castration-resistant prostate cancer.
I-Apalutamide isetyenziselwa ukunyanga iintlobo ezithile zomhlaza we-prostate onganyangekiyo okanye umhlaza we-prostate ongakhange usasazeke kwamanye amalungu omzimba, kodwa awuzange uncedwe ngolunye unyango lwezonyango.I-Apalutamide ikwiklasi yamayeza abizwa ngokuba yi-androgen receptor inhibitors.Isebenza ngokuthintela iziphumo ze-androgen ukuyeka ukukhula kunye nokusasazeka kweeseli zomhlaza.Ngomhla we-17 kuSeptemba, ngo-2019, uLawulo lokuTya kunye neDrugs lwamkele i-Apalutamide (ERLEADA, iJanssen Biotech, Inc) kwizigulana ezinomhlaza wedlala lobudoda (mCSPC) we-metastatic castration.I-Apalutamide yamkelwa okokuqala ngo-2018 kwizigulana ezinomhlaza we-prostate ongeyo-metastatic castration-resistant.
