Trelagliptin Succinate Intermediate CAS 865759-24-6 Ubunyulu >98.0% (HPLC)

Inkcazelo emfutshane:

I-Trelagliptin Succinate ePhakathi-int D

I-CAS: 865759-24-6

Ubunyulu: >98.0% (HPLC)

Imbonakalo: Okumhlophe-Kumhlophe ukuya kwiCrystal etyheli

Umbindi weTrelagliptin Succinate (CAS: 1029877-94-8) kunyango lweSifo seswekile sesibini

Qhagamshelana: UGqr. Alvin Huang

Iselula/Wechat/WhatsApp: +86-15026746401

E-Mail: alvin@ruifuchem.com

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Iinkcukacha zeMveliso

Iimveliso ezinxulumeneyo

Iithegi zeMveliso

Inkcazo:

Ubonelelo ngezoRhwebo lweTrelagliptin Succinate eziNxulumeneyo neziPhakathi:
I-6-Chloro-3-Methyluracil CAS 4318-56-3
I-2-Cyano-5-Flurobenzyl Bromide CAS 421552-12-7
(R)-(-)-3-Aminopiperidine Dihydrochloride CAS 334618-23-4
Trelagliptin Succinate Intermediate-int D CAS 865759-24-6
I-Trelagliptin Succinate CAS 1029877-94-8
Please contact: alvin@ruifuchem.com

Iipropati zeMichiza:

Igama leMchiza	I-Trelagliptin Succinate ePhakathi-int D
Izithethantonye	2-((6-Chloro-3-Methyl-2,4-dioxo-3,4-dihydropyriMidin-1(2H)-yl)Methyl)-4-fluorobenzonitrile;2 - [(6-Chloro-3,4-dihydro-3-methyl-2,4-dioxo-1 (2H) -pyrimidinyl) methyl] -4-fluorobenzonitrile
Ukungcola	Ukungacoceki kweTrelagliptin 17
Ubume beStokhwe	Kwisitokhwe, isikali soRhwebo
Inombolo yeCAS	865759-24-6
Ifomula yeemolekyuli	I-C13H9ClFN3O2
Ubunzima beMolekyuli	293.68 g/mol
Ukuxinana	1.49±0.10 g/cm3
Ugcino Temp.	Indawo epholileyo kunye neyomileyo
I-COA kunye ne-MSDS	Iyafumaneka
Uphawu	Ruifu Chemical

Iinkcukacha:

Izinto	ImiGangatho yokuHlola	Iziphumo
Imbonakalo	Okumhlophe-kuMhlophe ukuya kwikristale emthubi	Iyahambelana
Ukuchongwa
HPLC	Ixesha lokugcinwa kwesampulu yovavanyo oluphambili luthobela umgangatho wereferensi	Iyahambelana
I-IR - I-Infrared Spectrum	I-IR yokufunxa i-spectra yesampuli kunye nomgangatho ziyahambelana	Iyahambelana
Ukuhlolwa
Ilahleko ekomisweni	<0.50%	0.3%
Ukungcola ngokupheleleyo	<2.00%	Iyahambelana
Ubunyulu / Indlela yokuHlalutya	>98.0% (HPLC)	99.1%
Ukuqukumbela	Imveliso ivavanyiwe kwaye iyahambelana neenkcukacha

Ukupakishwa/uGcino/Ukuhambisa ngenqanawe:

Umqulu:Ibhotile, ingxowa yefoyile yeAluminiyam, 25kg/Igubu lekhadibhodi, okanye ngokwemfuno yomthengi.
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Ipakethe ye-OEM: Iphakheji yesiko kunye neleyibhile ekhoyo

Ukuhanjiswa ngokukhawuleza: Ukuba ngaphakathi kwesitokhwe, ukuhanjiswa kweentsuku ezintathu kuqinisekisiwe

Ubonelelo oluzinzileyo: Gcina isitokhwe esifanelekileyo

Inkxaso yobuGcisa: Isisombululo seTekhnoloji siyafumaneka

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Umgangatho ophezulu: Kusekwe inkqubo epheleleyo yokuqinisekisa umgangatho

FAQ:

Ukuthenga njani?Nceda uqhagamshelaneDr. Alvin Huang: sales@ruifuchem.com or alvin@ruifuchem.com

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Isicelo:

I-2-((6-chloro-3-Methyl-2,4-dioxo-3,4-dihydropyriMidin-1(2H)-yl)Methyl)-4-fluorobenzonitrile (CAS: 865759-24-6) isetyenziswa njenge phakathi kweTrelagliptin Succinate (CAS: 1029877-94-8).I-Trelagliptin Succinate, ephuhliswe nguTakeda, eJapan, eyasungulwa ngo-Matshi 2015, phantsi kwegama lezorhwebo elithi Zafatek, isetyenziselwa ukunyanga isifo seswekile se-2.I-Trelagliptin yi-ultra-long-acting dipeptidyl peptidase IV(DPP-4) inhibitor ngokukhetha nangokuqhubekayo inqanda i-DPP-4 ukulawula amanqanaba eswekile yegazi.I-Trelagliptin liyeza lokuqala leveki le-hypoglycemic kwimarike, kwaye i-DPP-4 inhibitors efanayo kwimarike kufuneka ithathwe kanye ngosuku.Izibonelelo zamayeza eZafatek ngokungathandabuzekiyo ziya kubonelela ngeendlela zonyango eziluncedo kwizigulana ezinesifo seswekile.Kulindeleke ukuba kuphuculwe kakhulu ukulungeleka kunye nokuthotyelwa kwezigulane.ngoMatshi 26, 2015, isigebenga amayeza Japanese Takeda wabhengeza ukuba ichiza elitsha seswekile Zafatek yamkelwe yi-Japan Ministry of Health, Labor and Welfare (MHLW) kunyango lwe-2 seswekile.Ukuvunywa kuphawula ukuba i-Zafatek ibe liyeza lokuqala leveki le-hypoglycemic yomlomo kwimarike kwihlabathi, kwaye imele i-blockbuster ewiswe ngu-Takeda kwimarike yesifo sikashukela.
I-Trelagliptin sisithinteli se-dipeptidyl peptidase IV (DPP-4) se-dipeptidyl peptidase IV (DPP-4) esilawula amanqanaba eswekile yegazi ngokukhetha nangokuqhubekayo i-DPP-4.I-DPP-4 yi-enzyme enokuqalisa ukungasebenzi kwe-incretin (i-glucagon-like peptide -1 (GLP-1) kunye ne-glucose-dependent insulinotropic polypeptide (GIP) ), edlala indima ebalulekileyo ekulawuleni i-glucose yegazi.Ukuvinjelwa kwe-DPP-4 kunokunyusa izinga leshukela legazi elixhomekeke kwi-insulin secretion, ngaloo ndlela ilawula izinga leswekile yegazi.Ukungeniswa kwe-Trelagliptin NDA kusekelwe kwimpumelelo kunye nedatha yokhuseleko evela kwisigaba se-III solingo lwezonyango oluqhutywe kwizigulane zaseJapan ezinesifo seswekile se-2.Ukusebenza kweTrelagliptin kuqinisekisiwe kulo lonke ulingo, kwaye inokhuseleko olulungileyo kunye nokunyamezela.Ulawulo lwe-Trelagliptin kanye ngeveki lunokulawula ngokufanelekileyo inqanaba leswekile yegazi kwaye kulindeleke ukuba luphucule ukuthotyelwa kwamayeza ezigulane.