Crizotinib Intermediate CAS 877399-00-3 Ubunyulu ≥98.0% (HPLC) ee ≥99.0%
I-Shanghai Ruifu Chemical Co., Ltd. ngumenzi ohamba phambili we (R) -5-Bromo-3-[1-(2,6-Dichloro-3-Fluorophenyl) ethoxy]pyridin-2-Amine (CAS: 877399-00 -3) kunye nomgangatho ophezulu, ophakathi kweCrizotinib (CAS: 877399-52-5).I-Ruifu Chemical inokubonelela ngenkonzo yehlabathi jikelele, ixabiso elikhuphisanayo, inkonzo egqwesileyo, encinci kunye nezixa ezininzi ezikhoyo.Thenga iCrizotinib ePhakathi,Please contact: alvin@ruifuchem.com
| Igama leMchiza | (R) -5-Bromo-3-[1-(2,6-Dichloro-3-Fluorophenyl) ethoxy]pyridin-2-Amine |
| Izithethantonye | iCrizotinib ePhakathi;Ukungcola kweCrizotinib Bromide;5-Bromo-3-[(1R)-1-(2,6-Dichloro-3-Fluorophenyl) ethoxy]-2-Pyridinamine;[5-Bromo-3-[(1R)-(2,6-Dichloro-3-Fluorophenyl)ethoxy]pyridin-2-yl]amine |
| Ubume beStokhwe | Kwi-Stock, iMveliso yoRhwebo |
| Inombolo yeCAS | 877399-00-3 |
| Ifomula yeemolekyuli | I-C13H10BrCl2FN2O |
| Ubunzima beMolekyuli | 380.04 g/mol |
| Indawo yokunyibilika | 108.0 ukuba 113.0℃ |
| Ukuxinana | 1.643 |
| I-COA kunye ne-MSDS | Iyafumaneka |
| Isampulu | Iyafumaneka |
| Imvelaphi | Shanghai, China |
| Udidi | Phakathi kweCrizotinib (CAS: 877399-52-5) |
| Uphawu | Ruifu Chemical |
| Izinto | ImiGangatho yokuHlola | Iziphumo |
| Imbonakalo | Umthubi oKhanyayo ukuya kwiPowder emthubi ukuya kwiCrystal | Iyahambelana |
| Indawo yokunyibilika | 108.0 ukuba 113.0℃ | Iyahambelana |
| Ucoceko (Ummandla weHPLC) | ≥98.0% | 99.1% |
| I-Enantiomeric Excess (EE) | ≥99.0% | 99.5% |
| I-Infrared Spectrum | Iyahambelana neSakhiwo | Iyahambelana |
| I-1 H NMR Spectrum | Iyahambelana neSakhiwo | Iyahambelana |
| Ukuqukumbela | Le mveliso ivavanyiwe kwaye iyahambelana neenkcukacha | |
| Beka ubomi kwishelufa | Iminyaka emi-2 ukuba igcinwe ngokufanelekileyo | |
Umqulu:Ibhotile, ingxowa yefoyile yeAluminiyam, 25kg/Igubu lekhadibhodi, okanye ngokwemfuno yomthengi.
Imeko yoGcino:Gcina isikhongozeli sivalwe ngokuqinileyo kwaye usigcine kwindawo epholileyo, eyomileyo (2~8℃) kunye nendawo yokugcina impahla engena moya ikude kwizinto ezingahambelaniyo.Khusela ukukhanya kunye nokufuma.
Ukuhambisa ngenqanawe:Zisa kwihlabathi liphela ngomoya, ngeFedEx / DHL Express.Ukubonelela ngokukhawuleza nangokuthembekileyo.
Ukuthenga njani?Nceda uqhagamshelaneDr. Alvin Huang: sales@ruifuchem.com or alvin@ruifuchem.com
Amava Eminyaka Eli-15?Sineminyaka engaphezu kwe-15 yamava ekwenziweni nasekuthumeleni kumazwe angaphandle uluhlu olubanzi oluphezulu lwamayeza aphakathi okanye amachiza alungileyo.
Iimarike eziphambili?Thengisa kwimarike yasekhaya, eMntla Melika, eYurophu, eIndiya, eKorea, eJapan, eOstreliya, njl.
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UmgangathoIsiqinisekiso?Inkqubo yokulawula umgangatho ongqongqo.Izixhobo zobuchwephesha zokuhlalutya ziquka i-NMR, LC-MS, GC, HPLC, ICP-MS, UV, IR, OR, KF, ROI, LOD, MP, Clarity, Solubility, Microbial limit test, njl.
Iisampulu?Uninzi lweemveliso zibonelela ngeesampulu zasimahla zokuvavanya umgangatho, iindleko zokuthumela kufuneka zihlawulwe ngabathengi.
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Ixesha lokuzisa? Ukuba ngaphakathi kwesitokhwe, ukuhanjiswa kweentsuku ezintathu kuqinisekisiwe.
Ezothutho?Nge-Express (FedEx, DHL), ngoMoya, ngoLwandle.
Amaxwebhu?Emva kwenkonzo yokuthengisa: I-COA, i-MOA, i-ROS, i-MSDS, njl.
Udibaniso lweSiko?Inokubonelela ngeenkonzo zesiko lokudibanisa ukuze zilungele iimfuno zakho zophando.
Immimiselo yokuhlawula?I-invoyisi yeProforma iya kuthunyelwa kuqala emva kokuqinisekiswa kwe-odolo, efakwe kwiinkcukacha zethu zebhanki.Intlawulo nge-T / T (i-Telex Transfer), i-PayPal, i-Western Union, njl.
(R) -5-Bromo-3-[1- (2,6-Dichloro-3-Fluorophenyl) ethoxy]pyridin-2-Amine (CAS: 877399-00-3) isetyenziswe njengendawo ephakathi yeCrizotinib (CAS: 877399-52-5).
I-Crizotinib ngokuqinisekileyo iyeza elichasayo lomhlaza liba yi-alk (i-anaplastic lymphoma kinase) kunye ne-ros1 (c-ros oncogene 1) inhibitor, evunyiweyo kunyango lwe-non-small cell lung carcinoma (NSCLC) e-USA nakwamanye amazwe, kwaye Iqhuba izifundo ezininzi ezivavanya ukhuseleko lwayo kunye nokusebenza kwayo kwi-anaplastic enkulu yeseli lymphoma, neuroblastoma, kunye namanye amathumba aqinileyo aphambili kubantu abadala kunye nabantwana.
I-Crizotinib lichiza lonyango ekujoliswe kulo lomhlaza wemiphunga weseli ongengomncinci ophuhliswe nguPfizer, eU.SA, i-secorri ngumda kunye neyeza elenza i-epoch kwicandelo lonyango ekujoliswe kulo kumhlaza wemiphunga.Yavunywa ukuba ithengiswe e-United States ngo-Agasti ka-2011 kwaye yabhalwa kwizikhokelo zonyango lomhlaza wemiphunga wamazwe ngamazwe ekupheleni konyaka njengechiza lokuqala lezigulane ezine-ALK-positive.I-Co-evunywe kunye ne-Crizotinib yindlela yokuqala yokuxilongwa kwemfuzo usebenzisa i-fluorescence in situ hybridization (FISH) -VSIs I-ALK Break Apart FISH Probe Kit, le yindlela esetyenziswayo ngoku kwizilingo zeklinikhi zehlabathi ukufumana i-EML4-ALK i-fusion ye-NSCLC.Olu vavanyo luya kunceda ukuchonga izigulane ezinokuzuza kunyango lweCrizotinib.
I-Crizotinib yinto ekhethiweyo ye-tyrosine kinase receptor inhibitor esetyenziswa kunyango lweemeko ezikhethiweyo zomhlaza wamaphaphu ongeyena omncinci omncinci.I-ATP i-inhibitor ekhuphisana kabini ye-tyrosine kinases c-MET (i-Mesenchymal-Epithelial Transition Factor) kinase (i-cellular IC50 = 8 nM) kunye ne-ALK (i-cellular IC50 = 20 nM), zombini iithagethi ezibalulekileyo ze-chemotherapy yomhlaza.Xa i-Crizotinib ivavanyelwa ukukhetha ngokuchasene nezinye i-kinases kwafunyaniswa ukuba i-enzyme IC50's ngaphakathi kwe-100-fold multiples ye-c-MET ye-13 ye-120 kinases ihlolwe.Kwiimvavanyo zeselula, i-Crizotinib yafunyanwa inhibitha i-RON (i-recepteur d'origine nantais) kinase enefestile ye-10-fold selectivity over c-MET.Lilonke, le arhente inqanda ukukhula kweseli yethumba.I-XALKORI®(Crizotinib) liyeza elimiselweyo elisetyenziselwa ukunyanga abantu abanomhlaza wemiphunga ongengowomncinci (NSCLC) othe wanwenwela kwamanye amalungu omzimba kwaye ubangelwa sisiphene nokuba kukwijini ekuthiwa yi-ALK (anaplastic lymphoma kinase) okanye ijini ebizwa ngokuba yiROS1.Akwaziwa ukuba iXALKORI ikhuselekile kwaye iyasebenza ebantwaneni.
