1-Boc-4-(4-Bromopyrazol-1-yl)piperidine CAS 877399-50-3 Ubunyulu ≥98.0% (HPLC)
I-Shanghai Ruifu Chemical Co., Ltd. ngumenzi ohamba phambili we-1-Boc-4- (4-Bromopyrazol-1-yl)piperidine (CAS: 877399-50-3) enomgangatho ophezulu, ophakathi kweCrizotinib (CAS: 877399- 52-5).I-Ruifu Chemical inokubonelela ngenkonzo yehlabathi jikelele, ixabiso elikhuphisanayo, inkonzo egqwesileyo, encinci kunye nezixa ezininzi ezikhoyo.Thenga iCrizotinib Intermediates,Please contact: alvin@ruifuchem.com
| Igama leMchiza | I-1-Boc-4- (4-Bromopyrazol-1-yl) ipiperidine |
| Izithethantonye | Crizotinib-D;tert-Butyl 4-(4-Bromopyrazol-1-yl)piperidine-1-Carboxylate;4-(4-Bromopyrazol-1-yl)piperidine-1-Carboxylic Acid tert-Butyl Ester;I-1-tert-Butoxycarbonyl-4-(4-Bromopyrazol-1-yl)piperidine;1-(4-Boc-Piperidino)-4-Bromopyrazole;1-Boc-4-(4-Bromo-1-Pyrazolyl)piperidine;I-4-Bromo-1-(N-Boc-Piperidin-4-yl)-1H-Pyrazole;tert-butyl 4-(4-Bromo-1H-Pyrazol-1-yl)piperidine-1-Carboxylate;I-1-(4-Boc-1-Piperidinyl) -4-Bromopyrazole;Ukungacoceki kweCrizotinib 4 |
| Ubume beStokhwe | Kwi-Stock, iMveliso yoRhwebo |
| Inombolo yeCAS | 877399-50-3 |
| Ifomula yeemolekyuli | I-C13H20BrN3O2 |
| Ubunzima beMolekyuli | 330.23 g/mol |
| Indawo yokunyibilika | 77.0 ukuba 81.0℃ |
| Ukuxinana | 1.43 |
| Ukunyibilika | Inyibilika kwiMethanol |
| I-COA kunye ne-MSDS | Iyafumaneka |
| Imvelaphi | Shanghai, China |
| Udidi | Phakathi kweCrizotinib (CAS: 877399-52-5) |
| Uphawu | Ruifu Chemical |
| Izinto | ImiGangatho yokuHlola | Iziphumo |
| Imbonakalo | Okumhlophe Okuqinileyo | Okumhlophe Okuqinileyo |
| Indawo yokunyibilika | 77.0 ukuba 81.0℃ | Iyahambelana |
| Amanzi nguKarl Fischer | <0.50% | 0.11% |
| Ubunyulu / Indlela yokuHlalutya | ≥98.0% (HPLC) | 99.3% |
| I-1H NMR Spectrum | Iyahambelana neSakhiwo | Iyahambelana |
| IMisa | Iyahambelana neSakhiwo | Iyahambelana |
| Ukuqukumbela | Imveliso ivavanyiwe kwaye iyahambelana neenkcukacha ezinikiweyo | |
Umqulu:Ibhotile, ingxowa yefoyile yeAluminiyam, 25kg/Igubu lekhadibhodi, okanye ngokwemfuno yomthengi.
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Ukuthenga njani?Nceda uqhagamshelaneDr. Alvin Huang: sales@ruifuchem.com or alvin@ruifuchem.com
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Iimpawu zeHazard Xn - Ziyingozi
IiKhowudi zoMngcipheko 22-Inobungozi xa iginyiwe
I-1-Boc-4- (4-Bromopyrazol-1-yl) piperidine (CAS: 877399-50-3) isetyenziswe njengendawo ephakathi kweCrizotinib (CAS: 877399-52-5).I-Crizotinib (igama lokurhweba i-Xalkori,) lichiza elichasene nomhlaza elisebenza njenge-ALK (i-anaplastic lymphoma kinase) kunye ne-ROS1 (c-ros oncogene 1) inhibitor, evunyiweyo unyango lwe-non-small cell lung carcinoma (NSCLC) e-US. kunye namanye amazwe, kunye novavanyo lweklinikhi oluvavanya ukhuseleko kunye nokusebenza kwayo inanaplastic enkulu yeseli lymphoma, neuroblastoma, kunye namanye amathumba aqinileyo aqhubela phambili kubantu abadala kunye nabantwana.
Ngo-Agasti 2011, i-United States FDA yavuma i-Crizotinib (PF- 02341066) yonyango lwe-anaplastic lymphoma kinase (ALK) iphinde yahlengahlengisa umhlaza wemiphunga we-non-small-cell (NSCLC).I-Crizotinib yi-inhibitor ekhuphisanayo ye-ATP ye-tyrosine kinases c-MET (i-Mesenchymal-Epithelial Transition Factor) kinase (i-cellular IC50 = 8 nM) kunye ne-ALK (i-cellular IC50 = 20 nM), zombini ezo zinjongo ezibalulekileyo zekhemotherapy yomhlaza.Xa i-Crizotinib ivavanyelwa ukukhetha ngokuchasene nezinye i-kinases kwafunyaniswa ukuba i-enzyme IC50's ngaphakathi kwe-100-fold multiples ye-c-MET ye-13 ye-120 kinases ihlolwe.Kwiimvavanyo zeselula, i-Crizotinib yafunyanwa inhibitha i-RON (i-recepteur d'origine nantais) kinase enefestile ye-10-fold selectivity over c-MET.
