1-(1-Boc-4-Piperidinyl)-4-Iodopyrazole CAS 877399-73-0 Ubunyulu ≥99.0% (HPLC)
I-Shanghai Ruifu Chemical Co., Ltd. ngumenzi ohamba phambili we-1-(1-Boc-4-Piperidinyl)-4-Iodopyrazole (CAS: 877399-73-0) enomgangatho ophezulu, ophakathi kweCrizotinib (CAS: 877399-52) -5).I-Ruifu Chemical inokubonelela ngenkonzo yehlabathi jikelele, ixabiso elikhuphisanayo, inkonzo egqwesileyo, encinci kunye nezixa ezininzi ezikhoyo.Thenga iCrizotinib Intermediates,Please contact: alvin@ruifuchem.com
| Igama leMchiza | I-1-(1-Boc-4-Piperidinyl)-4-Iodopyrazole |
| Izithethantonye | 1-Boc-4-(4-Iodo-1H-Pyrazol-1-yl)piperidine;tert-Butyl 4-(4-Iodo-1H-Pyrazol-1-yl)piperidine-1-Carboxylate;tert-Butyl 4-(4-Iodopyrazolyl)piperidinecarboxylate;Ukungacoceki kweCrizotinib 16 |
| Ubume beStokhwe | Kwi-Stock, iMveliso yoRhwebo |
| Inombolo yeCAS | 877399-73-0 |
| Ifomula yeemolekyuli | C13H20IN3O2 |
| Ubunzima beMolekyuli | 377.22 g/mol |
| Indawo yokunyibilika | 97℃ |
| Ukuxinana | 1.60±0.10 g/cm3 |
| Inovakalelo | Ukukhanya okunovelwano |
| Ugcino Temp. | 2 ~ 8℃, Khusela Ekukhanyeni |
| I-COA kunye ne-MSDS | Iyafumaneka |
| Imvelaphi | Shanghai, China |
| Udidi | Phakathi kweCrizotinib (CAS: 877399-52-5) |
| Uphawu | Ruifu Chemical |
| Izinto | ImiGangatho yokuHlola | Iziphumo |
| Imbonakalo | Okumhlophe ukuya kokuKhanya okutyheli okuqinileyo | Okumhlophe Okuqinileyo |
| Ubunyulu / Indlela yokuHlalutya | ≥99.0% (HPLC) | 99.58% |
| I-Infrared Spectrum | Iyahambelana neSakhiwo | Iyahambelana |
| I-1 H NMR Spectrum | Iyahambelana neSakhiwo | Iyahambelana |
| ESI+ | Iyahambelana | Iyahambelana |
| Ukuqukumbela | Imveliso ivavanyiwe kwaye iyahambelana neenkcukacha ezinikiweyo | |
Umqulu:Ibhotile, ingxowa yefoyile yeAluminiyam, 25kg/Igubu lekhadibhodi, okanye ngokwemfuno yomthengi.
Imeko yoGcino:Gcina isikhongozeli sivalwe ngokuqinileyo kwaye usigcine kwindawo epholileyo, eyomileyo (2~8℃) kunye nendawo yokugcina impahla engena moya ikude kwizinto ezingahambelaniyo.Khusela ukukhanya kunye nokufuma.
Ukuhambisa ngenqanawe:Zisa kwihlabathi liphela ngomoya, ngeFedEx / DHL Express.Ukubonelela ngokukhawuleza nangokuthembekileyo.
Ukuthenga njani?Nceda uqhagamshelaneDr. Alvin Huang: sales@ruifuchem.com or alvin@ruifuchem.com
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I-1-(1-Boc-4-Piperidinyl) -4-Iodopyrazole (CAS: 877399-73-0) enomgangatho ophezulu, ophakathi kweCrizotinib (CAS: 877399-52-5).I-Crizotinib lichiza lonyango ekujoliswe kulo lomhlaza wemiphunga weseli ongengomncinci ophuhliswe nguPfizer, eU.SA, i-secorri ngumda kunye neyeza elenza i-epoch kwicandelo lonyango ekujoliswe kulo kumhlaza wemiphunga.Yavunywa ukuba ithengiswe e-United States ngo-Agasti ka-2011 kwaye yabhalwa kwizikhokelo zonyango lomhlaza wemiphunga wamazwe ngamazwe ekupheleni konyaka njengechiza lokuqala lezigulane ezine-ALK-positive.I-Co-evunywe kunye ne-Crizotinib yindlela yokuqala yokuxilongwa kwemfuzo usebenzisa i-fluorescence in situ hybridization (FISH) -VSIs I-ALK Break Apart FISH Probe Kit, le yindlela esetyenziswayo ngoku kwizilingo zeklinikhi zehlabathi ukufumana i-EML4-ALK i-fusion ye-NSCLC.Olu vavanyo luya kunceda ukuchonga izigulane ezinokuzuza kunyango lweCrizotinib.ngomhla wama-25, eli lichiza lokuqala ukuba lisetyenziswe kunyango lwezigulane ezinomhlaza wemiphunga we-cell okanye we-metastatic non-small cell lung (NSCLC) eyi-anaplastic lymphoma kinase (ALK) -positive njengoko kumiselwe luvavanyo oluvunyiweyo lwe-SFDA.
I-Crizotinib (PF-02341066) I-Crizotinib yi-c-Met enamandla kunye ne-ALK inhibitor, amaxabiso e-IC50 kwi-cell assay yayiyi-11 nM kunye ne-24 nM, ngokulandelanayo.Kwakhona i-inhibitor enamandla ye-ROS1 enexabiso le-Ki elingaphantsi kwe-0.025 nM.I-Crizotinib inokwenza i-autophagy kwiindidi ezahlukeneyo zomhlaza wemiphunga ngokuthintela indlela ye-STAT3.
