CAS 928672-86-0 Purity ≥99.0% (HPLC) API
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Inombolo yeCAS | 928672-86-0 |
Inombolo yeCAT | RF-API22 |
Ubume beStokhwe | Kwi-Stock, iMveliso yeMveliso ukuya kumakhulu eeKilogram |
Ifomula yeemolekyuli | I-C24H27FO6S |
Ubunzima beMolekyuli | 462.53 |
Uphawu | Ruifu Chemical |
Into | Iinkcukacha |
Imbonakalo | Umgubo oMhlophe |
Ukuchongwa | I-HPLC/NMR |
Ukunyibilika | Inyibilika kakhulu kwiMethanol;Inyibilika kwi-Ethanol, iAcetonitrile;Inyibilika kancinane emanzini |
Ubunyulu / Indlela yokuHlalutya | ≥99.0% (HPLC) |
Ukungacoceki komntu | ≤0.10% |
Ukungcola ngokupheleleyo | ≤0.50% |
Izinyibilikisi ezishiyekileyo | |
IMethanol | ≤3000ppm |
I-Ethanol | ≤5000ppm |
Acetonitrile | ≤400ppm |
Dichloromethane | ≤600ppm |
I-Ethyl Acetate | ≤5000ppm |
I-THF | ≤720ppm |
Toluene | ≤890ppm |
Umgangatho woVavanyo | I-Pharmacopoeia yaseTshayina (CP);Umgangatho woShishino |
Ukusetyenziswa | I-Active Pharmaceutical Ingredient (API);I-SGLT-2 inhibitors Uhlobo lwe-2 yesifo seswekile |
Iphakheji: Ibhotile, ingxowa yefoyile yeAluminiyam, 25kg/Igubu lekhadibhodi, okanye ngokwemfuno yomthengi
Imeko yoGcino:Gcina kwizikhongozeli ezivaliweyo kwindawo epholileyo neyomileyo;Khusela ekukhanyeni, ukufuma
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Lichiza leklasi ye-gliflozin okanye i-subtype 2 ye-sodium-glucose transport inhibitors (SGLT2) esetyenziselwa unyango lwe-2 yeswekile.Yaphuhliswa nguMitsubishi Tanabe Pharma kwaye ithengiswa phantsi kwelayisensi nguJanssen, icandelo likaJohnson & Johnson.Ijongene nobuncinci be-90% ye-glucose reabsorption kwizintso.Ukuthintela esi sithuthi kubangela ukuba iswekile yegazi iphele ngomchamo.Ngo-Matshi 2013, yaba yi-SGLT2 inhibitor yokuqala ukuba ivunywe e-United States.To khankanya inzuzo, eli chiza linceda izigulane ukunciphisa iishukela zegazi ngaphandle kokunyusa amathuba okufumana ubunzima nje ngokuba kulandelwa ukutya okunempilo, okunokulinganisela kunye nokuzivocavoca rhoqo.Ukongeza, inethemba elibanzi ngenxa yeziphumo zayo ezibalulekileyo ze-antiobesity kunye neziganeko ezimbalwa ze-hypoglycemic.
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