CAS 945667-22-1 Ucoceko >99.0% (HPLC) API Umfanekiso ofakiweyo

CAS 945667-22-1 Ubunyulu > 99.0% (HPLC) API

Inkcazelo emfutshane:

CAS: 945667-22-1

Ubunyulu: >99.0% (HPLC)

Imbonakalo: Umgubo oMhlophe

I-API, uMgangatho oPhezulu, iMveliso yoRhwebo

E-Mail: alvin@ruifuchem.com

Thumela i-imeyile kuthi

Iinkcukacha zeMveliso

Iimveliso ezinxulumeneyo

Iithegi zeMveliso

Inkcazo:

Ruifu Chemical Supply Related Intermediates
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Iipropati zeMichiza:

Izithethantonye	I-BMS-477118 Hydrate;I-Onglyza Hydrate;(1S,3S,5S)-2-[(2S)-2-Amino-2-(3-Hydroxy-1-Adamantyl)acetyl]-2-Azabicyclo [3.1.0]hexane-3-Carbonitrile Hydrate;(1S,3S,5S)-2-[(S)-2-Amino-2-[(1r,3R,5R,7S)-3-Hydroxyadamantan-1-yl]acetyl]-2-Azabicyclo [3.1.0 ]hexane-3-Carbonitrile Hydrate
Inombolo yeCAS	945667-22-1
Inombolo yeCAT	RF-PI1992
Ubume beStokhwe	Kwi-Stock, iMveliso yoMveliso ukuya kwiiToni
Ifomula yeemolekyuli	C18H25N3O2·H2O
Ubunzima beMolekyuli	333.43
Uphawu	Ruifu Chemical

Iinkcukacha:

Into	Iinkcukacha
Imbonakalo	Umgubo oMhlophe
ukuchongwa	A: IR B: Ixesha lokugcinwa kweHPLC
Ubunyulu / Indlela yokuHlalutya	>99.0% (HPLC, Kwisiseko Esomileyo)
Isiqulatho samanzi (KF)	5.3%~7.3%
Intsalela kwi-Ignition	<0.20%
Ukungacoceki Okukodwa	<0.50%
Ukungcola ngokupheleleyo	<1.00%
Iintsimbi ezinzima	<10ppm
IArsenic (As)	<2ppm
IMicrobiology
Ukubalwa kwePleti iyonke	<1000cfu/g
Igwele kunye noMngundo	<100cfu/g
E. Coli	Ibi
S. Aureus	Ibi
Salmonella	Ibi
Beka ubomi kwishelufa	Iinyanga ezingama-24
Umgangatho woVavanyo	Umgangatho woShishino
Ukusetyenziswa	API;Isetyenziselwa uNyango lweSifo seswekile sesibini

Ukupakishwa kunye noGcino:

Iphakheji: Ibhotile, ingxowa yefoyile yeAluminiyam, 25kg/Igubu lekhadibhodi, okanye ngokwemfuno yomthengi

Imeko yoGcino:Gcina kwizikhongozeli ezivaliweyo kwindawo epholileyo neyomileyo;Khusela ukukhanya kunye nokufuma

Izinto eziluncedo:

FAQ:

Isicelo:

I-API (i-CAS: i-945667-22-1) yi-inhibitor ekhethiweyo kunye ne-reversible dipeptidyl peptidase-4 (DPP4) engasetyenziselwa ukuphuhlisa unyango lwe-2 yeswekile.Yi-inhibitor ye-DPP4 ekhethiweyo kunye ne-reversible kunye ne-IC50 ye-26 nM kunye ne-Ki ye-1.3 nM.IC50 ixabiso: 26 nM.Ithagethi: DPP4 in vitro: Ine-inhibition constant Ki ye-1.3 nM ye-DPP4 inhibition, ephindwe ka-10 ngamandla kune-Sitagliptin (enye i-DPP4 inhibitors ezimbini) ene-Ki ye-13 kunye ne-18 nM.Ukongeza, Ibonisa ukucaciswa okukhulu kwe-DPP4 kunokuba i-DPP8 okanye i-DPP9 enzymes (400- kunye ne-75-fold, ngokulandelanayo).Imetablite esebenzayo yayo iphindwe kabini ingaphantsi ngamandla kunomzali.Bobabini (i-CAS: i-945667-22-1) kunye ne-metabolite yayo ikhetha kakhulu (> I-4000-fold) yokukhusela i-DPP4 xa kuthelekiswa noluhlu lwezinye iiproteases.(CAS: 945667-22-1) inciphisa ukuthotywa kwe-incretin hormone glucagon-like peptide-1, ngaloo ndlela iphucula izenzo zayo, kwaye inxulunyaniswa nomsebenzi ophuculweyo we-β-cell kunye nokunyanzeliswa kwe-glucagon secretion.in vivo: Isebenza kakhulu. ekufuneni ukuphuculwa kwedosi ephawulweyo kwi-glucose clearance kwi-dose range 0.13-1.3 mg/kg kwi-ob/ob mice ngokumalunga nolawulo.