I-4-Chloro-6-Iodoquinazoline CAS 98556-31-1 Ubunyulu > 98.0% (HPLC)

Inkcazelo emfutshane:

Igama leKhemikhali: 4-Chloro-6-Iodoquinazoline

CAS: 98556-31-1

Ubunyulu: >98.0% (HPLC)

Imbonakalo: Umhlaba omthubi ukuya kumgubo oMthubi-omdaka

Phakathi kweLapatinib / Lapatinib Ditosylate Monohydrate

Qhagamshelana: UGqr. Alvin Huang

Iselula/Wechat/WhatsApp: +86-15026746401

E-Mail: alvin@ruifuchem.com

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Iinkcukacha zeMveliso

Iimveliso ezinxulumeneyo

Iithegi zeMveliso

Inkcazo:

I-Shanghai Ruifu Chemical Co., Ltd. ngumenzi ohamba phambili we-4-Chloro-6-Iodoquinazoline (i-CAS: 98556-31-1) enomgangatho ophezulu.I-Ruifu Chemical inokubonelela ngenkonzo yehlabathi jikelele, ixabiso elikhuphisanayo, inkonzo egqwesileyo, encinci kunye nezixa ezininzi ezikhoyo.Thenga i-4-Chloro-6-Iodoquinazoline,Please contact: alvin@ruifuchem.com

AbaPhakathi beLapatinib:

Isiseko seLapatinib	I-CAS 231277-92-2
ILapatinib Ditosylate Monohydrate	I-CAS 388082-78-8
Isodium methanesulfinate	I-CAS 20277-69-4
3-Chloro-4-(3-Fluorobenzyloxy)aniline	I-CAS 202197-26-0
I-2-Aminoethyl Methyl Sulfone Hydrochloride	I-CAS 104458-24-4
4-Chloro-6-Iodoquinazoline	I-CAS 98556-31-1
I-6-Iodo-4-Hydroxyquinazoline	I-CAS 16064-08-7
I-5-Formyl-2-Furanboronic Acid	I-CAS 27329-70-0
5-[4-[3-Chloro-4-(3-Fluorobenzyloxy)anilino]-6-Quinazolinyl]furan-2-Carboxaldehyde	I-CAS 231278-84-5

Iipropati zeMichiza:

Igama leMchiza	4-Chloro-6-Iodoquinazoline
Izithethantonye	I-6-Iodo-4-Chloroquinazoline
Ubume beStokhwe	Kwi-Stock, iMveliso yoRhwebo
Inombolo yeCAS	98556-31-1
Ifomula yeemolekyuli	C8H4ClIN2
Ubunzima beMolekyuli	290.49 g/mol
Indawo yokunyibilika	175.0 ukuya 179.0℃
Ukuxinana	2.017±0.06 g/cm3
Refractive Index n20/D	1.739
Inovakalelo	Ubuthathaka bomoya
I-COA kunye ne-MSDS	Iyafumaneka
Imvelaphi	Shanghai, China
Uphawu	Ruifu Chemical

Iinkcukacha:

Izinto	ImiGangatho yokuHlola	Iziphumo
Imbonakalo	Umhlaba oMthubi ukuya kwiPowder etyheli-bumdaka	Umhlaba Yellow Powder
Indawo yokunyibilika	175.0 ukuya 179.0℃	177.2℃
Ilahleko ekomisweni	<1.00%	0.15%
Ubunyulu / Indlela yokuHlalutya	>98.0% (HPLC)	98.43%
I-1H NMR Spectrum	Ngokungqinelana noLwakhiwo	Iyahambelana
Ukuqukumbela	Imveliso ivavanyiwe kwaye ihambelana neenkcukacha ezinikiweyo
Isicelo	Phakathi kweLapatinib / Lapatinib Ditosylate Monohydrate

Ukupakishwa/uGcino/Ukuhambisa ngenqanawe:

Umqulu:Ibhotile eFluorinated, iAluminium foil bag, 25kg/Cardboard Drum, okanye ngokwemfuno yomthengi.
Imeko yoGcino:Gcina isikhongozeli sivaliwe kwaye usigcine kwindawo epholileyo, eyomileyo nengena umoya kakuhle kude nezinto ezingahambelaniyo.Khusela ukukhanya kunye nokufuma.
Ukuhambisa ngenqanawe:Zisa kwihlabathi liphela ngomoya, ngeFedEx / DHL Express.Ukubonelela ngokukhawuleza nangokuthembekileyo.

Izinto eziluncedo:

Umthamo owaneleyo: Izixhobo ezaneleyo kunye namagcisa

Inkonzo yobuNgcali: Inkonzo enye yokuyeka ukuthenga

Ipakethe ye-OEM: Iphakheji yesiko kunye neleyibhile ekhoyo

Ukuhanjiswa ngokukhawuleza: Ukuba ngaphakathi kwesitokhwe, ukuhanjiswa kweentsuku ezintathu kuqinisekisiwe

Ubonelelo oluzinzileyo: Gcina isitokhwe esifanelekileyo

Inkxaso yobuGcisa: Isisombululo seTekhnoloji siyafumaneka

Inkonzo yesiNtu yoHlanganiso: Isuka kwiigram ukuya kwiikhilos

Umgangatho ophezulu: Kusekwe inkqubo epheleleyo yokuqinisekisa umgangatho

FAQ:

Ukuthenga njani?Nceda uqhagamshelaneDr. Alvin Huang: sales@ruifuchem.com or alvin@ruifuchem.com
Amava Eminyaka Eli-15?Sineminyaka engaphezu kwe-15 yamava ekwenziweni nasekuthumeleni kumazwe angaphandle uluhlu olubanzi oluphezulu lwamayeza aphakathi okanye amachiza alungileyo.
Iimarike eziphambili?Thengisa kwimarike yasekhaya, eMntla Melika, eYurophu, eIndiya, eKorea, eJapan, eOstreliya, njl.
Iingenelo?Umgangatho ophezulu, ixabiso elifikelelekayo, iinkonzo zengcali kunye nenkxaso yobugcisa, ukuhanjiswa ngokukhawuleza.
UmgangathoIsiqinisekiso?Inkqubo yokulawula umgangatho ongqongqo.Izixhobo zobuchwephesha zokuhlalutya ziquka i-NMR, LC-MS, GC, HPLC, ICP-MS, UV, IR, OR, KF, ROI, LOD, MP, Clarity, Solubility, Microbial limit test, njl.
Iisampulu?Uninzi lweemveliso zibonelela ngeesampulu zasimahla zokuvavanya umgangatho, iindleko zokuthumela kufuneka zihlawulwe ngabathengi.
Factory Audit?Uphicotho-zincwadi lwasefektri wamkelekile.Nceda wenze idinga kwangaphambili.
MOQ?Akukho MOQ.Umyalelo omncinci wamkelekile.
Ixesha lokuzisa? Ukuba ngaphakathi kwesitokhwe, ukuhanjiswa kweentsuku ezintathu kuqinisekisiwe.
Ezothutho?Nge-Express (FedEx, DHL), ngoMoya, ngoLwandle.
Amaxwebhu?Emva kwenkonzo yokuthengisa: I-COA, i-MOA, i-ROS, i-MSDS, njl.
Udibaniso lweSiko?Inokubonelela ngeenkonzo zesiko lokudibanisa ukuze zilungele iimfuno zakho zophando.
Immimiselo yokuhlawula?I-invoyisi yeProforma iya kuthunyelwa kuqala emva kokuqinisekiswa kwe-odolo, efakwe kwiinkcukacha zethu zebhanki.Intlawulo nge-T / T (i-Telex Transfer), i-PayPal, i-Western Union, njl.

98556-31-1 - Isicelo:

I-4-Chloro-6-Iodoquinazoline (i-CAS: 98556-31-1) yindawo ephakathi kwi-synthesis yeLapatinib (CAS: 231277-92-2) / Lapatinib Ditosylate Monohydrate (CAS: 388082-78-8).
I-Lapatinib lichiza elitsha elijoliswe kumhlaza webele elijoliswe kunyango eliphuhliswe kwaye lenziwe yi-GlaxoSmithKline, elavunywa yi-US Food and Drug Administration ngo-Matshi 13, 2007. Isalathisi esivunyiweyo ngoku sidibaniswe ne-capecitabine yomhlaza webele ophezulu okanye we-metastatic, kunye nezigulane zomhlaza webele. kufuneka zinyangwe ngamanye amayeza odidi lokuqala.Igama layo lokurhweba eUnited States yiTykerb.Ngomhla we-14 kaDisemba, i-2007, i-Arhente yeMithi yaseYurophu (EMEA) yavuma uluhlu lweLapatinib eYurophu phantsi kwegama lezorhwebo elithi Tyverb.Unyango olujoliswe kwimolekyuli yomhlaza wamabele lubhekisa kunyango lwe-oncogenes kunye neemveliso ezihambelanayo zokubonisa ezinxulumene nokwenzeka kunye nophuhliso lomhlaza wamabele.Amachiza ajoliswe kwimolekyuli anqanda okanye abulale iiseli zethumba ngokuthintela ukudluliselwa komqondiso kwiiseli zethumba okanye iiseli ezinxulumene nokulawula utshintsho kwintetho yemfuza yeseli.I-Lapatinib yi-molecule yomlomo encinci ye-epidermal growth factor tyrosine kinase inhibitor.Ulingo lwezonyango lubonise ukuba kwi-HER2 izigulane zomhlaza webele eziye zahlakulela ukuchasana ne-Roche's Herceptin (i-Herceptin), i-Lapatinib inesiphumo esihle seklinikhi.Uvavanyo lwe-in vitro, iLapatinib yaba nefuthe elibambekayo lokukhula kwi-Her-2 overexpressing Breast cancer lines.KwiSigaba soku-I sovavanyo lomhlaza webele okwinqanaba eliphezulu kunye ne-Her-2 overexpression, iLapatinib nayo inezinga eliphezulu elisebenzayo kwaye ayinayo ukumelana neHerceptin (trastuzumab).Ngenxa yokuba ukwakheka kwayo kuyimolekyuli encinci, ngokungafaniyo neHerceptin (trastuzumab), inokungena kumqobo wegazi-ingqondo kwaye ibe nefuthe elithile lonyango kwimetastasis yobuchopho yomhlaza wamabele.