I-Chloramphenicol CAS 56-75-7 Ucoceko ≥99.0% (HPLC) Ucoceko oluPhezulu
Ubonelelo loMvelisi ngokucoceka okuPhezulu kunye neMveliso yoRhwebo
(1R,2R)-(-)-2-Amino-1-(4-nitrophenyl)-1,3-propanediol CAS 716-61-0
(1S,2S)-(+)-2-Amino-1-(4-nitrophenyl)-1,3-propanediol CAS 2964-48-9
I-Chloramphenicol CAS 56-75-7
Igama leMchiza | Chloramphenicol |
Izithethantonye | D-(-)-threo-2-Dichloroacetamido-1- (4-nitrophenyl) -1,3-propanediol;2,2-Dichloro-N-[(1R,2R)-1,3-dihydroxy-1-(4-nitrophenyl)-2-propyl]acetamide |
Inombolo yeCAS | 56-75-7 |
Ubume beStokhwe | Kwi-Stock, iMveliso yoMveliso ukuya kwiiToni |
Ifomula yeemolekyuli | I-C11H12Cl2N2O5 |
Ubunzima beMolekyuli | 323.13 |
Indawo yokunyibilika | 149.0 ukuya 153.0℃ (lit.) |
Inovakalelo | Ukukhanya okunovelwano |
Ukunyibilika | Inyibilika kakhulu kwi-Ethanol, iMethanol, iAcetone.Inyibilika kwi-Ether, iChloroform.Ayinyibiliki kwi-Benzene.Ayinyibiliki ngokupheleleyo emanzini |
Imeko yokuthumela ngenqanawa | Ithunyelwe Ngaphantsi Kweqondo Lobushushu Le-Ambient |
I-COA kunye ne-MSDS | Iyafumaneka |
Imvelaphi | Shanghai, China |
Uphawu | Ruifu Chemical |
Into | Iinkcukacha |
Imbonakalo | Umgubo oMhlophe ukuya koMthubi oKhanyayo |
Isazisi A | Ukufunxwa kwe-infrared |
Isazisi B | Ixesha lokugcinwa kwencopho enkulu kwichromatogram yoLungiselelo lwe-Assay ihambelana naleyo kwichromatogram yoLungiselelo oluMgangatho, njengoko lufunyenwe kwi-Assay. |
Ujikelezo oluKhethekileyo lwe-Optical | +17.0 ° ~ + 20.0 ° |
Indawo yokunyibilika | 149.0 ~ 153.0℃ |
Ubukhazikhazi | Iyahlangabezana neeMfuno |
pH | 4.5~7.5 |
Ukungacoceki Okukodwa | ≤0.50% |
Ukungcola ngokupheleleyo | ≤1.00% |
Iintsimbi ezinzima | ≤20ppm |
Arsenic | ≤1ppm |
Ilahleko ekomisweni | ≤0.50% (105℃, iiyure ezi-3) |
Intsalela kwi-Ignition | ≤0.10% |
Ubunyulu / Indlela yokuHlalutya | ≥99.0% (HPLC) |
Umgangatho woVavanyo | uMgangatho woShishino;JP;USP |
Iphakheji: Ibhotile, ingxowa yefoyile yeAluminiyam, 25kg/Drum, okanye ngokwemfuno yomthengi.
Imeko yoGcino:Gcina kwizikhongozeli ezivaliweyo kwindawo epholileyo neyomileyo;Khusela ekukhanyeni, ukufuma.
Chloramphenicol
C11H12Cl2N2O5 323.13 [56-75-7].
I-Chloramphenicol ayinayo ngaphantsi kweepesenti ze-97.0 kwaye ingabi ngaphezu kwe-103.0 ipesenti ye-C11H12Cl2N2O5.
Ukupakishwa kunye nokugcinwa-Londoloza kwizikhongozeli eziqinileyo.
Ukuleyibhile-Apho kujongwe ukuba kusetyenziswe ekulungiseleleni iifomu zesitofu esitofwayo okanye ezinye iintsholongwane, ileyibhile ichaza ukuba ayinyumba okanye kufuneka ibekwe phantsi koqwalaselo oluthe kratya ngexesha lolungiselelo lwedosi etofwayo okanye ezinye iifom ezingcolileyo.
Imigangatho yezalathiso ye-USP <11>-
USP Chloramphenicol RS Cofa ukujonga iSakhiwo
USP Endotoxin RS
Isazisi-
A: I-Infrared Absorption <197K>.
B: Ixesha lokugcinwa kwencopho enkulu kwichromatogram yoLungiselelo lwe-Assay ihambelana naleyo kwichromatogram yoLungiselelo oluMgangatho, njengoko lufunyenwe kwi-Assay.
Uluhlu olunyibilikayo <741>: phakathi kwe-149 kunye ne-153.
Ukujikeleza okuthe ngqo <781S>: phakathi kwe +17.0 kunye +20.0.
Isisombululo sovavanyo: 50 mg, i-undried, i-mL nganye, kwi-alcohol dehydrated.
I-Crystallinity <695>: ihlangabezana neemfuno.
I-endotoxins ye-Bacterial 85-Apho i-Chloramphenicol yenzelwe ukusetyenziswa ekulungiseleleni iifom ze-dosage yokutofwa, ayinayo ngaphezu kwe-0.2 USP Endotoxin Unit nge-mg ye-chloramphenicol.
71-Apho ileyibhile ichaza ukuba i-Chloramphenicol ayinyumba, iyahlangabezana neemfuno xa ivavanywa njengoko kuchaziwe kuHlelo lweMembrane phantsi koVavanyo lokuNzala kweMveliso ekufuneka iVavanywe, ngaphandle kokusebenzisa i-1 g yomfanekiso oqinileyo.
pH <791>: phakathi kwe-4.5 kunye ne-7.5, ekumisweni kwamanzi okuqulethe i-25 mg nge-mL.
Ukucoceka kweChromatographic-Nyibilikisa ubungakanani obulinganiswe ngokuchanekileyo beChloramphenicol kwimethanol ukuze ufumane isisombululo sovavanyo esine-10 mg nge-mL nganye.Lungiselela isisombululo se-USP Chloramphenicol RS kwi-methanol equkethe i-10 mg nge-mL (Isisombululo esiqhelekileyo A).Nciphisa izahlulo zesisombululo esiMgangatho A ngokobuninzi ngemethanol ukufumana isisombululo esiseMgangathweni B esiqulathe i-100 µg ngemL kunye nesinyibiliko soMgangatho C esiqulethe i-50 µg ngemL.Faka iinxalenye ezahlukeneyo ze-20-µL zesisombululo sovavanyo kunye nezisombululo eziMgangatho B kunye no-C kwipleyiti ecekethekileyo yechromatographic (bona iChromatography 621), eqatywe nge-0.25-mm yomxube wejeli ye-chromatographic.Phuhlisa ichromatogram kwinkqubo yokunyibilikisa equka umxube wekloroform, i-methanol, kunye ne-glacial acetic acid (79:14:7) de i-solvent front ihambe malunga nesithathu-esine yobude beplate.Susa ipleyiti kwigumbi, i-air-dry, kwaye uhlolisise phantsi kokukhanya okufutshane kwe-UV: nayiphi na indawo ngaphandle kwendawo eyintloko efunyenwe kwisisombululo sovavanyo ayigqithisi ngobukhulu okanye ubukhulu bendawo ephambili efunyenwe kwisisombululo esisemgangathweni B (1% ), kunye nesixa sobumdaka obumelwe ngawo onke amabala ngaphandle kwendawo ephambili, esekelwe kuthelekiso lokuqina kwaloo mabala kunye nokuqina kweendawo eziphambili ezifunyenwe kwizisombululo zoMgangatho B no-C, azidluli kwi-2% .
Isivavanyi-
Isigaba seselula-Lungisa umxube ococekileyo ococekileyo wamanzi, i-methanol, kunye ne-glacial acetic acid (55: 45: 0.1).Yenza uhlengahlengiso xa kukho imfuneko (jonga ukufaneleka kweNkqubo phantsi kweChromatography 621).
Ulungiselelo olusemgangathweni- Nyibilikisa isixa esinomlinganiso ochanekileyo we USP Chloramphenicol RS kwisigaba seMobile, kwaye unyibilike ngokobuninzi, kwaye ulandele inyathelo xa kukho imfuneko, ngesigaba seMobile ukufumana isisombululo esinoxinzelelo olwaziwayo malunga nama 80 µg ngemL.Hluza inxalenye yesi sisombululo nge-0.5-µm okanye isihluzo esicolekileyo se-porosity, kwaye usebenzise isihluzo esicacileyo njengolungiselelo loMgangatho.
Ukulungiswa kwe-Assay- Dlulisa malunga ne-200 mg ye-Chloramphenicol, ilinganiswe ngokuchanekileyo, kwi-flask ye-volumetric ye-100-mL, yongeza isigaba se-Mobile kwivolumu, kwaye udibanise.Dlulisa i-4.0 mL yesisombululo esisiphumo kwi-flask ye-volumetric ye-100-mL, i-dilute kunye nesigaba se-Mobile ukuya kumthamo, kwaye udibanise.Hluza inxalenye yesi sisombululo nge-0.5-µm okanye isihluzo se-porosity esicolekileyo, kwaye usebenzise isihluzo esicacileyo njengolungiselelo lwe-Assay.
Inkqubo yeChromatographic (jonga i-Chromatography <621>)-I-chromatograph yolwelo ixhotyiswe nge-280-nm detector kunye nekholamu ye-4.6-mm × 10-cm equlethe i-5-µm yokupakisha i-L1.Izinga lokuhamba malunga ne-1 mL ngomzuzu.I-Chromatograph Ukulungiswa koMgangatho, kwaye urekhode iimpendulo eziphakamileyo njengoko zichazwe phantsi kweNkqubo: ukusebenza kakuhle kwekholomu kugqitywe kwincopho ye-analyte ayikho ngaphantsi kwe-1800 yamacwecwe eethiyori, i-tailing factor ayikho ngaphezu kwe-2.0, kunye nokuphambuka okusemgangathweni ohambelanayo kwi-injection ephindaphindayo ayikho. ngaphezu kwe-1.0%.
Inkqubo--[Qaphela-Sebenzisa umphakamo ophakamileyo apho iimpendulo eziphezulu zibonisiwe.] Ngokwahlukileyo tofa imiqulu elinganayo (malunga ne-10 µL) yoLungiselelo oluMgangatho noLungiselelo loVavanyo kwichromatograph, urekhode iichromatogram, kwaye ulinganise iimpendulo zeencopho ezinkulu.Bala ubuninzi, kwi-mg, ye-C11H12Cl2N2O5 kwisahlulo seChloramphenicol esithathwe ngefomula:
2.5C(rU / rS)
apho uC lugxininiso, kwi-µg ngemL, ye-USP Chloramphenicol RS kulungiselelo loMgangatho, kunye ne-rU kunye ne-rS ziimpendulo eziphezulu ezifunyenwe kulungiselelo loVavanyo kunye nolungiselelo loMgangatho, ngokulandelelanayo.
Chloramphenicol
C11H12Cl2N2O5: 323.13
2,2-Dichloro-N-[(1R,2R)-1,3-dihydroxy-1-(4-nitrophenyl)propan-2-yl]acetamide [56-75-7]
I-Chloramphenicol iqulethe ngaphantsi kwe-980 mg (i-potency) kwaye ingabi ngaphezu kwe-1020 mg (i-potency) nge-mg, ibalwa kwisiseko esomileyo.Amandla eChloramphenicol abonakaliswa njengobunzima (amandla) we-chloramphenicol (C11H12Cl2N2O5).
Ingcaciso I-Chloramphenicol yenzeka imhlophe ukuya kumhlophe tyheli, iikristale okanye umgubo wekristale.
Inyibilika ngokukhululekileyo kwi-methanol nakwi-ethanol (99.5), kwaye inyibilika kancinane emanzini.
Ukuchongwa (1) Ukumisela i-spectrum yokuxutywa kwesisombululo sesampuli efunyenwe kwi-Assay njengoko iqondiswe phantsi kwe-Ultraviolet-visible Spectrophotometry <2.24>, kwaye uthelekise i-spectrum kunye ne-Reference Spectrum okanye i-spectrum yesisombululo se-Chloramphenicol RS elungiselelwe ngendlela efanayo. Isisombululo sesampulu: zombini iispectra zibonisa ukomelela okufanayo kokufunxa kubude bamaza obufanayo.
(2) Qinisekisa i-spectrum yokufunxa i-infrared ye-Chloramphenicol njengoko iqondiswe kwindlela ye-potassium bromide disk phantsi kwe-Infrared Spectrophotometry <2.25>, kwaye uthelekise i-spectrum kunye ne-Reference Spectrum okanye i-spectrum ye-Chloramphenicol RS: zombini i-spectra ibonisa ukuqina okufanayo kwi-absorption efanayo. amanani amaza.
Ukujikeleza kwe-Optical <2.49> [a] 20D: + 18.5 ~ + 21.5℃ (1.25 g, ethanol (99.5), 25 mL, 100 mm).
Indawo yokunyibilika <2.60> 150 ~ 155℃
Ukucoceka (1) Iintsimbi ezinzima <1.07>-Qhubeka kunye ne-1.0 g yeChloramphenicol ngokweNdlela yesi-2, kwaye wenze uvavanyo.Lungiselela isisombululo solawulo kunye ne-2.5 mL yeSisombululo esiPhambili esiPhambili (kungekho ngaphezu kwe-25 ppm).
(2) Arsenic <1.11> -Lungisa isisombululo sovavanyo kunye ne-2.0 g yeChloramphenicol ngokweNdlela yesi-4, kwaye wenze uvavanyo (kungekho ngaphezu kwe-1 ppm).
(3) Izinto ezinxulumeneyo-Dibanisa i-0.10 g yeChloramphenicol kwi-10 mL ye-methanol, kwaye usebenzise esi sisombululo njengesisombululo sesampuli.Umbhobho we-1 mL wesisombululo sesampulu, yongeza i-methanol ukwenza i-100 mL ngqo, kwaye usebenzise esi sisombululo njengesisombululo esiqhelekileyo (1).Umbhobho we-10 mL wesisombululo esiqhelekileyo (1), yongeza i-methanol ukwenza i-20 mL ngqo, kwaye usebenzise esi sisombululo njengesisombululo esiqhelekileyo (2).Yenza uvavanyo ngezi zisombululo njengoko kuqondiswe phantsi kwe-Thin-layer Chromatography <2.03>.Ibala i-20 mL nganye yesisombululo sesampuli kunye nezisombululo eziqhelekileyo (1) kunye (2) kwipleyiti ye-silica gel kunye nesalathisi se-fluorescent ye-chromatography ebhityileyo, ukuphuhlisa ipleyiti ngomxube we-chloroform, i-methanol kunye ne-acetic acid (100) ( 79:14:7) ukuya kumgama omalunga ne-15 cm, kwaye yomise ngomoya ipleyiti.Hlola phantsi kokukhanya kwe-ultraviolet (i-wavelength engundoqo: 254 nm): amabala angaphandle kwendawo eyintloko kunye nebala elifunyenwe kwisisombululo sesampulu alinamandla ngaphezu kwendawo efunyenwe kwisisombululo esiqhelekileyo (1), kunye ne-amunt iyonke. kula mabala avela kwisisombululo sesampuli ayikho ngaphezu kwe-2.0%.
Ilahleko ekomisweni <2.41> Akukho ngaphezu kwe-0.5% (1 g, 105℃, iiyure ezi-3).
Intsalela ekutshisweni <2.44> Akukho ngaphezu kwe-0.1% (1 g).
Uvavanyo Yenza umlinganiselo ngokuchanekileyo ubungakanani beChloramphenicol kunye neChloramphenicol RS, elingana ne-0.1 g (amandla), nyibilikisa nganye kwi-20 mL yemethanol, kwaye wongeze amanzi ukwenza i-100 mL ngqo.Umbhobho we-20mL nganye kwezi zisombululo, kwaye wongeze amanzi ukwenza i-100mL ngqo.Umbhobho we-10 ml nganye kwezi zisombululo, yongeza amanzi ukwenza i-100 mL ngqo, kwaye usebenzise ezi zisombululo njengesampulu yesisombululo kunye nesisombululo esisemgangathweni.Ukumisela i-absorbences, i-AT kunye ne-AS, kwi-278 nm yesisombululo sesampuli kunye nesisombululo esiqhelekileyo njengoko silawulwa phantsi kwe-Ultraviolet-visible Spectrophotometry <2.24>.
Isixa [mg (amandla)] se-chloramphenicol (C11H12Cl2N2O5)
= MS × AT/AS × 1000
MS: Isixa [mg (amandla)] seChloramphenicol RS
ithathiwe
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I-Shanghai Ruifu Chemical Co., Ltd. ngumthengisi ohamba phambili weChloramphenicol (CAS: 56-75-7) enomgangatho ophezulu.I-Chloramphenicol yi-antibacterial antibiotic ebanzi, eyona nto ikhethwa kuqala kunyango lwe-typhoid kunye ne-paratyphoid, okwesibini, isetyenziselwa ukunyanga izifo ezahlukeneyo ezosulelayo ezibangelwa yi-microorganisms enovakalelo.Ngenxa yeziphumo ezibi kakhulu ngoku zisetyenziswa kancinci nangaphantsi.I-antibacterial spectrum, umsebenzi kunye nokusetyenziswa kuyafana ne-chloramphenicol yonyango lwe-Salmonella Typhi, i-Shigella, i-Escherichia coli, i-influenza, i-Brucella, izifo ze-pneumonia ezibangelwa yi-cocci kunye nezinye i-antibiotics anti-infective drugs.I-Chloramphenicol isetyenziswa ikakhulu ukunyanga usulelo lwe-urinary tract, inyumoniya, usulelo lwesisu kunye ne-septicemia ebangelwa yintsholongwane ebuthathaka, kunye namathontsi angaphandle kunye namathontsi endlebe.
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