I-Citicoline Sodium yeTyuwa Hydrate CAS 33818-15-4 Assay ≥98.0% Ucoceko oluPhezulu
Umenzi onobunyulu obuPhezulu kunye noMgangatho oZinzile
Igama leKhemikhali: Citicoline Sodium
CAS: 33818-15-4
Umgangatho ophezulu, iMveliso yoRhwebo
Igama leMchiza | Citicoline sodium |
Izithethantonye | CDPC;CDP-Choline;Cytidine 5'-Diphosphocholine Ityuwa yeSodium |
Inombolo yeCAS | 33818-15-4 |
Inombolo yeCAT | RF-API09 |
Ubume beStokhwe | Kwi-Stock, iMveliso yoMveliso ukuya kwiiToni |
Ifomula yeemolekyuli | I-C14H27N4NaO11P2 |
Ubunzima beMolekyuli | 512.32 |
Indawo yokunyibilika | 259.0~268.0℃ (dec.) |
Ukunyibilika kwamanzi | Inyibilika emanzini |
Imeko yokuthumela ngenqanawa | Phantsi koBubushushu be-Ambient |
Uphawu | Ruifu Chemical |
Into | Iinkcukacha |
Imbonakalo | Ikristale emhlophe okanye i-Crystalline Powder, engenavumba |
Ukunyibilika | Inyibilika ngokukhululekileyo emanzini, ayinyibiliki kwi-ethanol, kwi-acetone nakwi-chloroform |
Ukuchongwa | Umbala wempendulo yesisombululo yaba kukusabela okulungileyo |
Ukuchongwa | Ixesha lokugcinwa kwencopho enkulu yesisombululo sesampulu kufuneka ihambelane naleyo yomgangatho wereferensi. |
Ukuchongwa | I-infrared absorption spectrum iyahambelana ne-reference spectrum |
Ukuchongwa | Isisombululo se-aquous sivelisa iimpawu zokusabela kwiityuwa zesodium |
Ukucaca kunye nombala wesisombululo | Kufuneka icace kwaye ingabi mbala |
Iikloridi | ≤0.05% |
Ityuwa ye-ammonium | ≤0.05% |
Intsimbi | ≤0.01% |
Iphosphate | ≤0.10% |
Ilahleko ekomisweni | ≤6.0% |
Iintsimbi ezinzima | ≤0.0005% |
Arsenic | ≤0.0001% |
Iintsholongwane ze-Endotoxins | ≤0.30 EU/mg |
Ubalo lweBhaktheriya iyonke | ≤1000cfu/g |
Igwele kunye nokungunda | ≤100cfu/g |
E.Coli | Ayifunyanwa |
5'-CMP | ≤0.30% |
Okunye ukungcola okulula | ≤0.20% |
Okunye Ukungcola Okupheleleyo | ≤0.70% |
I-Residual Solvent Methanol | ≤0.30% |
I-Residual Solvent Ethanol | ≤0.50% |
Intsalela yokunyibilika kweAcetone | ≤0.50% |
Ubunyulu | ≥99.5% (Citicoline Sodium, Kubalwa kwisiseko esomileyo) |
Umgangatho woVavanyo | I-Pharmacopoeia yaseTshayina (Ayikho-Nzala ye-APIS) |
Ukusetyenziswa | API;AbaPhakathi bamayeza |
Iphakheji: Ibhotile, ingxowa yefoyile yeAluminiyam, igubu lekhadibhodi, 25kg/Igubu, okanye ngokwemfuno yomthengi.
Imeko yoGcino:Gcina kwizikhongozeli ezivaliweyo kwindawo epholileyo neyomileyo;Khusela ekukhanyeni, ukufuma kunye nokuhlaselwa zizinambuzane.
I-Citicoline i-nucleic acid derivatives, uGeiger wafumanisa ukuba i-citicoline inokubuyisela ukulimala kwengqondo kwiimvavanyo zezilwanyana kwi-1956. Uphononongo lukaKennedy luqinisekisile ukuba i-citicoline inokwenza ukubuyisela ukulimala kwengqondo kwi-1957. Yabhaliswa e-China kwi-1988, kwaye ngoku iyona nto ithengiswa kakhulu. ichiza phakathi kwezifo zengqondo zeklinikhi.Idlala indima ebalulekileyo kwi-synthesis ye-lecithin, ngokukhuthaza ukuhlanganiswa kwe-lecithin kunye nokuphucula ukusebenza kwengqondo.Iimvavanyo zibonisa ukuba i-citicoline inokuphucula amanqanaba e-norepinephrine kunye ne-dopamine kwinkqubo ye-nervous central, ngaloo ndlela inokunyanga isifo se-cerebrovascular, ukwenzakala kwengqondo ebuhlungu kunye nokuphazamiseka kwengqondo okubangelwa izizathu ezahlukeneyo, kwaye akukho miphumo icacileyo.
I-Citicoline sodium inokuphucula umsebenzi wengqondo ye-brain stem reticular formation, ngakumbi inkqubo yokunyuka ye-reticular activating ehambelana nokuqonda komntu;ukwandisa umsebenzi wenkqubo yepyramidal;inqanda umsebenzi wenkqubo yangaphandle ye-cone, kwaye ikhuthaza ukubuyiswa komsebenzi wenkqubo.Kunyango lwe-sequelae yokulimala kwengqondo ebuhlungu kunye nengozi ye-cerebral vascular ebangelwa yinkqubo ye-nervous, ingasetyenziselwa kunyango lwe-Parkinson's disease, i-senile dementia inefuthe elithile;kunyango lwezifo zentliziyo kunye ne-cerebrovascular;Kwakhona kunempembelelo ethile yokuchasa ukuguga, ukuphucula ukufunda kunye nememori.