Cyano-Irbesartan CAS 138401-24-8 Ubunyulu >98.0% (HPLC) Irbesartan Intermediate Factory
IRuifu Chemical Supply Irbesartan Intermediates:
Irbesartan CAS 138402-11-6
Cyano-Irbesartan CAS 138401-24-8
Trityl Irbesartan CAS 138402-10-5
I-TTBB CAS 124750-51-2
Irbesartan Side Chain Hydrochloride CAS 151257-01-1
Igama leMchiza | Cyano-Irbesartan |
Izithethantonye | iCyanoIrbesartan;Ukungacoceki kwe-Irbesartan Cyano;I-Irbesartan Hydrocarbon;Ukungcola kwe-Irbesartan 6;2-Butyl-3-[[2'-cyano-[1,1'-biphenyl]-4-yl]methyl]-1,3-diazaspiro[4,4]non-1-en-4-enye;4'-[(2-Butyl-4-oxo-1,3-diazaspiro[4,4]non-1-en-3-yl)methyl]-[1,1'-biphenyl] -2-carbonitrile |
Inombolo yeCAS | 138401-24-8 |
Inombolo yeCAT | RF-PI1892 |
Ubume beStokhwe | Kwi-Stock, iMveliso yoMveliso ukuya kwiiToni |
Ifomula yeemolekyuli | I-C25H27N3O |
Ubunzima beMolekyuli | 385.51 |
Ukuxinana | 1.15 |
Ukunyibilika (Nyibilika ngaphakathi) | IMethanol |
Uphawu | Ruifu Chemical |
Into | Iinkcukacha |
Imbonakalo | Mhlophe ukuya Phantse uMhlophe uPowder ukuya kwiCrystal |
Ubunyulu / Indlela yokuHlalutya | >98.0% (HPLC) |
Ubunyulu | >97.0% (NgeNitrojeni iyonke) |
Indawo yokunyibilika | 91.0 ukuba 95.0℃ |
Ilahleko ekomisweni | <1.00% |
Ukungacoceki Okukodwa | <1.00% |
Iintsimbi ezinzima | <20ppm |
I-Infrared Spectrum | Iyahambelana noLwakhiwo |
Umgangatho woVavanyo | Umgangatho woShishino |
Ukusetyenziswa | Phakathi / Ukungacoceki kwe-Irbesartan (CAS: 138402-11-6) |
Iphakheji: Ibhotile, ingxowa yefoyile yeAluminiyam, 25kg/Igubu lekhadibhodi, okanye ngokwemfuno yomthengi
Imeko yoGcino:Gcina kwizikhongozeli ezivaliweyo kwindawo epholileyo neyomileyo;Khusela ukukhanya kunye nokufuma
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I-Cyano-Irbesartan (i-CAS: 138401-24-8) iphakathi okanye ukungcola kwe-Irbesartan (CAS: 138402-11-6).I-Irbesartan yi-angiotensin II (i-Angiotensin II, i-Ang II) inhibitor ye-receptor.I-Angiotensin II receptors zihlukaniswe zibe zimbini iintlobo: i-AT1 kunye ne-AT2.I-Irbesartan ivala ngokukhetha i-AT1 receptor ye-AnglI.Inokuthintela ukuguqulwa kwe-Ang kwi-Ang, inokuchasa ngokukodwa i-angiotensin-converting enzyme 1 receptor (AT1).Isiphumo esichasayo kwi-AT1 ngama-8500 amaxesha e-AT2.Inokuthintela ngokukhethekileyo ukubopha i-Ang kunye ne-AT1 i-receptor nge-Inhibit vasoconstriction kunye nokukhululwa kwe-aldosterone, okubangelwa umphumo we-hypotensive.Le mveliso ayivimbeli i-angiotensin yokuguqula i-enzyme (i-ACE), i-renin, enye i-receptors ye-hormone, kwaye ayivimbeli iziteshi ze-ion ezinxulumene nokulawulwa kwengcinezelo yegazi kunye nebhalansi ye-sodium.I-Irbesartan inokunciphisa ukulungiswa kwakhona kombane kwi-myocardium, ngaloo ndlela inciphisa izinga lokufa kwezigulana ezinoxinzelelo lwegazi.Okwangoku lelona chiza lisebenzayo kunyango loxinzelelo lwegazi kunye nezifo zentliziyo.
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