D-(+)-Cycloserine CAS 68-41-7 Assay ≥ 900μg/mg Factory High Quality
I-Shanghai Ruifu Chemical Co., Ltd. ngumenzi ohamba phambili we-D-(+)-Cycloserine (CAS: 68-41-7) enomgangatho ophezulu.I-Ruifu Chemical inokubonelela ngenkonzo yehlabathi jikelele, ixabiso elikhuphisanayo, amancinci kunye nenani elikhulu elikhoyo.Thenga i-D-(+)-Cycloserine,Please contact: alvin@ruifuchem.com
| Igama leMchiza | D-(+)-Cycloserine |
| Izithethantonye | D-Cycloserine;(+)-Cycloserine;(R)-(+)-Cycloserine;(R)-(+)-4-Amino-3-Isoxazolidinone;I-Orientomycin;iOxamycin;α-Cycloserine |
| Ubume beStokhwe | Ikhona evenkileni |
| Inombolo yeCAS | 68-41-7 |
| Ifomula yeemolekyuli | C3H6N2O2 |
| Ubunzima beMolekyuli | 102.09 g/mol |
| Indawo yokunyibilika | 137℃ |
| Inovakalelo | Ukungeva kuMoya, Ubushushu abuva |
| Ukunyibilika | Inyibilika emanzini.I-Soluble kancinane kwiMethanol kunye nePropylene Glycol.Ayinyibiliki kwiChloroform kunye ne-Ether. |
| Ugcino Temp. | Indawo epholileyo neyomileyo (2~8℃) |
| I-COA kunye ne-MSDS | Iyafumaneka |
| Uphawu | Ruifu Chemical |
| Izinto | ImiGangatho yokuHlola | Iziphumo |
| Imbonakalo | Umgubo weCrystalline oMhlophe okanye oMthubi | Iyahambelana |
| Ukujikeleziswa okuthe ngqo [α]20/D | +108.0 ° ukuya +114.0 ° (C=5, 2N NaOH) | +111.9 ° |
| Ukuchongwa | Umbala oBlue waphuhliswa ngokuthe ngcembe | Umbala oBlue |
| Iimveliso zokuNxibelela | ≤0.80% (ku-286nm) | 0.08% |
| Ilahleko ekomisweni | <1.00% | 0.38% |
| Intsalela kwi-Ignition | <0.50% | 0.10% |
| Iintsimbi ezinzima (Pb) | ≤10ppm | <10ppm |
| Ukungacoceki okuguquguqukayo | ||
| -Methanol | ≤500ppm | <500ppm |
| -Acetone | ≤500ppm | <500ppm |
| Uvavanyo (Antibiotics-Microbial Assay) | ≥900μg/mg | 938μg/mg |
| pH | 5.5 ukuya ku-6.5 | 5.98 |
| FTIR | Iyahambelana | Iyahambelana |
| IR Spectrum | Iyahambelana | Iyahambelana |
| NMR Spectrum | Iyahambelana | Iyahambelana |
| Ukuqukumbela | Le mveliso ngokuhlolwa ihambelana nomgangatho we-USP-35 | |
Cycloserine [68-41-7].
I-Cycloserine inamandla angekho ngaphantsi kwe-900µg ye-C3H6N2O2 nge-mg.
Ukupakishwa kunye nokugcinwa-Londoloza kwizikhongozeli eziqinileyo.
Imigangatho yezalathiso ye-USP <11>-
USP Cycloserine RS
Ukuchonga-Dibanisa malunga ne-1 mg kwi-10 mL ye-0.1 N sodium hydroxide.Kwi-1 ml yesisombululo esisiphumo songeza i-3 mL ye-1 N acetic acid kunye ne-1 mL yomxube, elungiselelwe iyure enye ngaphambi kokusetyenziswa, yeendawo ezilinganayo zesisombululo se-sodium nitroprusside (1 ku-25) kunye ne-4 N sodium hydroxide: umbala ozuba ngokuthe ngcembe. iphuhlisa.
Iimveliso ze-Condensation-I-absorptivity yayo (jonga i-Spectrophotometry kunye ne-Light-Scattering <851>) kwi-285 nm, enqunywe kwisisombululo se-0.1 N ye-sodium hydroxide equkethe i-0.40 mg nge-mL ayikho ngaphezu kwe-0.80.
Ukujikeleza okuthe ngqo <781S>: phakathi kwe-108 ° kunye ne-114 °.Isisombululo sovavanyo: 50 mg nge-mL, kwi-2 N sodium hydroxide.
I-Crystallinity <695>: ihlangabezana neemfuno
pH <791>: phakathi kwe-5.5 kunye ne-6.5, kwisisombululo (1 kwi-10).
Ilahleko ekomisweni <731>-Yomisa malunga ne-100 mg kwi-capillar y-stoppered ibhotile kwi-vacuum kwi-60 ℃ kwiiyure ze-3: ilahlekelwa ngaphezu kwe-1.0% yobunzima bayo.
Intsalela ekutshiseni <281>: akukho ngaphezu kwe-0.5%, i-residu etshisiweyo ixutywe nge-2 mL ye-nitric acid kunye ne-5 yehla ye-sulfuric acid.
Isivavanyi-
I-pH 6.8 i-Phosphate buffer-Lungisa njengoko kuyalelwe kwi-Buffer Solutions phantsi kweZisombululo kwicandelo le-Reagents, Izalathisi, kunye neziSombululo.
I-Mobile phase-Dissolve 0.5 g ye-sodium 1-decanesulfonate kwi-800 mL yamanzi, yongeza i-50 mL ye-acetonitrile kunye ne-5 mL ye-glacial acetic acid, kwaye udibanise.Lungisa nge-1 N sodium hydroxide ukuya kwi-pH ye-4.4.Isihluzo, kunye ne-degas.Yenza uhlengahlengiso ukuba kuyimfuneko y (jonga ukufaneleka kweNkqubo phantsi kweChromatography <621>).
Ukulungiswa okusemgangathweni-Nyibilikisa ngobungakanani obuchanekileyo ubungakanani be-USP Cycloserine RS kwi-pH 6.8 isithinteli sePhosphate ukufumana isisombululo esinoxinzelelo olwaziwayo malunga ne-0.4 mg nge-mL.
Ukulungiswa kwe-Assay-Transfer malunga ne-20 mg ye-Cycloserine, ilinganiswe ngokuchanekileyo, kwi-flask ye-volumetric ye-50-mL, chitha kwaye udibanise nge-pH 6.8 i-Phosphate buffer kwi-volume, kwaye udibanise.
Inkqubo yeChromatographic (jonga iChromatography <621>)-I-chromatograph yolwelo ixhotyiswe nge-219-nm detector kunye ne-4.6-mm × 25-cm ikholamu equlethe i-5- µm yokupakisha i-L1.Izinga lokuhamba malunga ne-1 mL ngomzuzu.Ubushushu bekholomu bugcinwa malunga ne-30 °.I-Chromatograph Ukulungiswa koMgangatho, kwaye urekhode iimpendulo eziphakamileyo njengoko zichazwe kwiNkqubo: i-tailing factor ayikho ngaphezu kwe-1.8;kunye nokutenxa komgangatho ozalanayo wokuphindaphinda iinaliti akukho ngaphezu kwe-2.0%.
Inkqubo-Ngokwahlukileyo tofa imithamo elinganayo (malunga ne-10 µL) yoLungiselelo oluMgangatho noLungiselelo lwe-Assay kwichromatograph, urekhode iichromatograms, kwaye ulinganise iincopho zeempendulo ze-cycloserine.Bala ubuninzi, kwiµg, ye-C3H6N2O2 kwimg nganye yeCycloserine ethathwe ngefomula:
50,000(C/W)(rU / rS)
apho i-C igxininise, kwi-mg nge-mL, ye-USP i-Cycloserine RS kulungiselelo olusemgangathweni;W ubuninzi, kwi-mg, ye-Cycloserine ethathiweyo ukulungiselela ukulungiswa kwe-Assay;kunye ne-rU kunye ne-rS yincopho yeempendulo ze-cycloserine ezifunyenwe kulungiselelo lwe-Assay kunye nolungiselelo loMgangatho, ngokulandelelanayo.
Umqulu:Ibhotile, ingxowa yefoyile yeAluminiyam, 25kg/Igubu lekhadibhodi, okanye ngokwemfuno yomthengi.
Imeko yoGcino:Gcina kwizikhongozeli ezivaliweyo kwindawo yokugcina impahla epholileyo neyomileyo (2~8℃) kude nezinto ezingahambelaniyo.Khusela ukukhanya kunye nokufuma.
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Ukuthenga njani?Nceda uqhagamshelaneDr. Alvin Huang: sales@ruifuchem.com or alvin@ruifuchem.com
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FLUKA BRAND F IIKHOWUDI 10-23
Ikhowudi yeHS 2941909099
I-D-(+)-Cycloserine (i-CAS: 68-41-7) inobume obuqinileyo be-hygroscopic, i-soluble emanzini, i-soluble kancinane kwi-alcohols ephantsi, i-acetone kunye ne-dioxane, kwaye i-soluble nge-chloroform kunye ne-petroleum ether.Izinzile ngokufanelekileyo kwisisombululo se-alkaline kwaye ibolile ngokukhawuleza kwisisombululo se-acidic okanye esingathathi hlangothi.Njengesithinteli-ntsholongwane esibanzi, i-cycloserine iyanqanda kwiibhaktheriya ezininzi ze-Gram-positive kunye ne-Gram-negative, i-rickettsia kunye ne-protozoa, ngaphandle kwe-Mycobacterium tuberculosis. ivinactane para-aminosalicylic acid, isoniazid kunye nepyrazinamide.I-Cycloserine idityaniswa kancinane ne-isoniazid ekuthinteleni i-Mycobacterium tuberculosis H37RV, kodwa ayidibanisi okanye ichase ngokuchasene ne-streptomycin.Imveliso yi-agent ye-bacteriostatic, kwaye ke ayizukwenza isiphumo se-bactericidal naxa unyusa idosi okanye usolula ixesha lesenzo kunye neebhaktheriya.
I-Mechanism yesenzo se-antibacterial ye-D-cycloserine kukuthintela i-biosynthesis ye-peptidoglycan yodonga lweseli.Njengoko i-analog yesakhiwo se-D-alanine, i-D-cycloserine inokuthintela ngokukhuphisanayo imisebenzi ye-alanine racemase kunye ne-D-alanyl-D-alanine synthetase, eziyi-enzyme ezimbini ezibalulekileyo kwi-peptidoglycan synthesis.I-D-cycloserine ibonisa umsebenzi obuthathaka othintelayo ngokuchasene ne-Mycobacterium tuberculosis eyi-1/10 ukuya kwi-1/20 kuphela ye-streptomycin.Inzuzo yemveliso kukuba iyasebenza kwiintlobo zesifo sephepha seMycobacterium enganyangekiyo ngamachiza kwaye ayinakwenzeka ukuba ibangele ukuxhathisa kumachiza.Imveliso ingasetyenziswa kunye namanye amachiza okulwa nesifo sephepha kunyango lwesifo sephepha esibangelwa sisifo sephepha esinganyangekiyo ngamachiza iMycobacterium.
I-Cycloserine liyeza elichasene nesifo sephepha kumgca wesibini.Inokuthintela ukukhula kwe-Mycobacterium tuberculosis, kodwa isiphumo sibuthathaka xa sithelekiswa neso samachiza odidi lokuqala.Ukusebenza kwayo kunyango lwesifo sephepha kuphantsi kakhulu.Ukusebenzisa iyeza kuphela kunokuvelisa ukuxhathisa kumachiza, kodwa ukuxhathisa kwenzeka kancinane xa kuthelekiswa nokwamanye amachiza alwa nesifo sephepha.Akukho ukuchasana okufunyenweyo phakathi kwe-cycloserine kunye namanye amachiza achasene nesifo sephepha.Inkqubo yesenzo sayo se-antibacterial kukuthintela ukuhlanganiswa kwe-peptidoglycan yodonga lweseli yebhaktiriya, ebangela isiphene kulwakhiwo lodonga lweseli.Inxalenye ephambili yesakhiwo sodonga lwebhaktheriya yi-peptidoglycan, ehlanganiswe ne-N-acetylglucosamine (GNAc) kunye ne-N-acetylmuramic acid (MNAc).I-N-acetylmuramic acid idibene ne-pentapeptide kwaye idibanisa i-N-acetylglucosamine ngendlela ephindwe kabini kunye nenye indlela.Ukuqulunqwa kwe-cytoplasmic peptidoglycan precursor kunokuphazanyiswa yi-cycloserine, njengoko le yokugqibela inokuthintela i-racemase kunye ne-synthetase ye-D-Alanine, kwaye ngaloo ndlela ivimbela ukubunjwa kwe-N-acetylmuramic acid.
I-D-Cycloserine inokufumaneka ngobuchule bokubila okanye ngokudibanisa ngokuthe ngqo.Ibhaktiriya esetyenziswa ekuvundiseni yiActinomyces laven-dulae.I-fermentation medium iqukethe i-dextrin, i-dextrose, isitashi, i-soybean powder, i-yeast powder, i-ammonium sulfate, i-ammonium nitrate, i-calcium carbonate, i-sodium chloride, i-magnesium sulfate kunye neoli ye-soybean.Kwinkqubo yokudibanisa, i-D-Cycloserine ifunyenwe kwi-β-Aminooxy alanine ethyl ester hydrochloride ngokuphendula nge-potassium hydroxide kwi-cyclization reaction.
