D-Phenylalanine CAS 673-06-3 (HD-Phe-OH) Uvavanyo 98.0~102.0% Factory 50MT/Inyanga
I-Shanghai Ruifu Chemical Co., Ltd. ngumenzi ohamba phambili kunye nomthengisi we-D-Phenylalanine (HD-Phe-OH) (i-CAS: 673-06-3) enomgangatho ophezulu, umthamo wokuvelisa iiToni ezingama-50 ngenyanga.I-D-Phenylalanine ibonwa ngamashishini amayeza asekhaya nakwamanye amazwe kunye namaziko ophando kunye nophuhliso.I-Ruifu Chemical ibonelela ngothotho lwee-amino acids eziphuma kuyo.Sinokubonelela nge-COA, ukuhanjiswa kwehlabathi jikelele, ubuninzi obuncinci kunye nobuninzi obukhoyo.Ukuba unomdla kwi-D-Phenylalanine,Please contact: alvin@ruifuchem.com
| Igama leMchiza | D-Phenylalanine |
| Izithethantonye | HD-Phe-OH;D-Phe;D-(+)-Phenylalanine;I-Dextro-Phenylalanine;(R)-Phenylalanine;(2R)-2-Amino-3-phenylpropanoic Acid;(R) -3-Phenyl-2-Aminopropanoic Acid;I-D-α-Amino-β-phenylpropionic Acid;I-D-alpha-Aminohydrocinnamic Acid;(R) -2-Amino-3-Phenylpropionic Acid;I-D-alpha-Amino-beta-Phenylpropionic Acid |
| Ubume beStokhwe | KwiSitokhwe, Umthamo weMveliso iiToni ezingama-50 ngenyanga |
| Inombolo yeCAS | 673-06-3 |
| Ifomula yeemolekyuli | C9H11NO2 |
| Ubunzima beMolekyuli | 165.19 |
| Indawo yokunyibilika | 273.0~276.0℃(lit.) |
| Ukuxinana | 1.201 |
| Ukunyibilika | I-Soluble kuManzi (30 mg/ml), i-Methanol (Kancinci), i-1 M HCl (50 mg/ml), i-Ethanol (<1 mg/ml kwi-25℃), kunye ne-DMSO (<1 mg/ml kwi-25℃) |
| Ukunyibilika kuManzi ashushu | Phantse Ukungafihli |
| Ugcino Temp. | Itywinwe kwindawo eyomileyo, iVenkile kwindawo yobushushu beGumbi |
| I-COA kunye ne-MSDS | Iyafumaneka |
| Ukuhlelwa | Amino Acids & Derivatives |
| Uphawu | Ruifu Chemical |
| Iikhowudi zeNgozi | Xi,C | RTECS | AY7533000 |
| Iingxelo zoMngcipheko | 34 - Ibangela ukutshisa | Inqaku Lengozi | Iyacaphukisa |
| Iingxelo zoKhuseleko | 24/25-45-36/37/39-27-26 | I-TSCA | Ewe |
| WGK eJamani | 3 | Ikhowudi ye-HS | 2922491990 |
| Izinto | ImiGangatho yokuHlola | Iziphumo |
| Imbonakalo | Iikristale eziMhlophe okanye umgubo weCrystalline | Iyahambelana |
| Ukuchongwa | I-Infrared Absorption Spectrum | Iyahambelana |
| Ukujikeleziswa okuthe ngqo [α]20/D | +33.5° ukuya +35.2°(C=2 kwi-H2O) | + 33,6 ° |
| Imeko yesisombululo (iTransmittance) | ≥95.0% | Iyahambelana |
| Ikloridi (Cl) | ≤0.020% | <0.020% |
| Isulfate (SO4) | ≤0.020% | <0.020% |
| I-Ammonium (NH4) | ≤0.020% | <0.020% |
| Intsimbi (Fe) | ≤10ppm | <10ppm |
| Iintsimbi ezinzima (Pb) | ≤10ppm | <10ppm |
| IArsenic (As2O3) | ≤2.0ppm | <2.0ppm |
| Ilahleko ekomisweni | ≤0.20% | 0.16% |
| Intsalela ekutshisweni (iSulfated) | ≤0.20% | 0.05% |
| D-Phenylalanine Ubunyulu | ≥99.0% (nge-HPLC) | 99.7% |
| D-Acetylphenylalanine | ≤0.10% | Ayifumanekanga |
| Izinyibilikisi ezishiyekileyo | (ngu-GC) | |
| I-Ethanol | ≤5000ppm | Ayifumanekanga |
| I-acetone | ≤5000ppm | Ayifumanekanga |
| Isivavanyi | 98.0 ukuya kwi-102.0% (Kwisiseko esomileyo) | 99.7% |
| L-Phenylalanine | ≤0.10% (nge-HPLC) | 0.07% |
| Ninhydrin Positive Substances | ≤0.20% | <0.18% |
| Ixabiso le-pH | 5.4 ukuya ku-6.0 | 5.8 |
| Ukuqukumbela | Le Mveliso ngokuHlolwa ngokuVumelana noMgangatho we-AJI97 | |
| Usetyenziso oluphambili | abaPhakathi bamayeza;AbaPhakathi beChiral;njl. | |
1. Imbonakalo-- Ukuhlolwa okubonakalayo
2. Ukujikeleza okuthe ngqo-- Ukujikeleza okuthe ngqo kulinganiswa ngokuhambelana ne-GB/T613-1988
Ukulungiselela isampulu: Viyisha ngokuchanekileyo isampuli ye-0.5000g kwaye uyihambise kwibhotile yevolumetric ecocekileyo neyomileyo ye-50ml, yongeza amanzi angama-20ml, gquma ibhotile, uyihlukumeze ukuze inyibilike, kwaye emva koko uyihlambulule kwisikali ngamanzi.
Uvavanyo: Lungisa i-zero ye-gyroscope ngaphambi kovavanyo, uze ulayishe ityhubhu yokuvavanya kunye nesisombululo sesampuli, urekhode i-Angle yokujikeleza, kwaye ubale ukujikeleza okuthe ngqo kwesampuli kunye nefomula elandelayo.
[а]D20 = (r×50) ÷(L×W)
Apho:
[а]D20: Ukujikeleza okuthe ngqo kwi-20 ℃ yesisombululo sesampuli
r: Ukujikeleza okubonakalayo kwi-20 ℃ kwisisombululo sesampuli
50: Umthamo wesisombululo sesampulu esilungisiweyo (ml)
w: Ubunzima besampulu (g)
L: Ubude betyhubhu ejikelezayo yokubona (dm)
3. Ukutshisa intsalela
Thatha malunga ne-1g yale mveliso kwaye uyitshise kwi-600 ℃, uyifudumeze de ibe luthuthu ngokupheleleyo ngokommiselo weSihlomelo Ⅷ N yeCandelo II le-CP2010 Edition, yongeza i-0.5-1.0ml egxininisiweyo ye-sulfuric acid kwaye uyifudumeze (700 ℃ - 800℃) kubunzima obuqhubekayo.
3.1 "Incandescent residue" kule Method (Chinese Pharmacopoeia 2005 Edition, Icandelo II Isihlomelo Ⅷ N) libhekisela oxides zesinyithi okanye sulfates eseleyo emva kokuba iziyobisi (ingakumbi iikhompawundi organic) zifudunyezwe de uthuthu ngokupheleleyo, ke sulfuric acid yongezwa 0.5 ~ 1.0ml kunye incandesced (700 ~ 800℃) ukuba ubunzima rhoqo.
4 Ucoceko lweChiral (HPLC)
Izixhobo: Ukusebenza okuphezulu kwechromatography yolwelo, umtshina wePDA.Ibhalansi yohlalutyo lwe-elektroniki, i-reagent;Inqanaba lekhromatografi
Iimeko zeChromatographic: Ikholomu: Ikholomu ye-Astec CHIROBIOTICTMT HPLC 250X4.6mm, 5ul, ubude be-wavelength, izinga lokuhamba, ubungakanani besampula: 10 u L (ireferensi) encinci: amanzi, ixesha lokuqokelela idatha: 20.00min.
Ukuzimisela kwesampuli: Isampuli yahlalutywa ngokwenkqubo yesampuli elandelayo: inaliti ye-1 yesisombululo esingenanto kunye nenaliti ye-1 ye-DL-phenylalanine reference.
1 isisombululo seesampuli senaliti,
Ukubalwa kweziphumo: Umxholo we-HPLC wamiselwa ukuba ube ngaphantsi kwe-0.5% ngokungqinelana nencopho yommandla wesiqhelo kunye nokuxhuzulwa okungenanto.
5. Yomile kwaye ayinabunzima
5.1 Izixhobo:
I-oven yokumisa i-Thermostatic, ibhalansi ye-1/10,000.
5.2 Inkqubo:
Kwibhotile yokulinganisa i-flat kunye nesisindo esingaguqukiyo kunye nesigqubuthelo somlomo womhlaba owomileyo, linganisa i-gram ye-1 (echanekileyo ukuya kwi-0.0001 gram) yesampuli.Isampulu kufuneka isasazwe ngokulinganayo emazantsi ebhotile yokulinganisa ngobunzima obungekho ngaphezu kwe-10mm, ifakwe kwi-oven yokumisa yombane ye-thermostatic, yome ngo-105-110 ℃ ngeeyure ezi-3, emva koko uye kwigumbi lokumisa ukuze uphole. ubushushu begumbi lokulinganisa.
Ukubala: Ukuncipha kobunzima %= (M1-M2) ÷M×100
Apho: I-M1: ubunzima besampulu kunye nebhotile yokulinganisa phambi kokuba yomiswe, iigram
M2: Ubunzima besampulu kunye nebhotile yokulinganisa emva kokumisa, kwiigram
M: Ubunzima besampulu, iigram
Inyathelo lesi-6: Umxholo
6.1 Izixhobo zokusebenza
Ukusebenza okuphezulu kwechromatography yolwelo, umtshina wePDA.
Ibhalansi yohlalutyo lwe-elektroniki
6.2 IiReagents
I-Acetonitrile (ibakala lechromatographic), TFA(ibakala lechromatographic)
6.3 Iimeko zeChromatographic
6.3.1 Umhlathi: YMC-ODS-AM, 5 μL, 150x4.6 mm
6.3.2 Ubungakanani bewavenge: INC220nm
Izinga lokuhamba: 1.0mL / min
Ubungakanani besampulu: 10μL(yereferensi)
Omncinci: Acetonitrile
Ixesha lokuqokelela idatha: 20.00min
6.4 Ukulungiswa kwesigaba esihambayo
Isigaba se-Mobile A (i-0.1% yamanzi e-trifluoroacetic acid): i-absorption echanekileyo 2. Nciphisa i-Oml trifluoroacetic acid ngamanzi ukuya kwi-2000m1, xuba kakuhle, kunye ne-degas;
Isigaba se-Mobile B (0.1% i-acetonitrile trifluoroacetic acid): i-absorption echanekileyo 2.Oml i-trifluoroacetic acid yahlanjululwa kwi-2000m1 kunye ne-acetonitrile, ixutywe kwaye ihlanjululwe;
6.5 Inkqubo yenqanaba lenqanaba elihambayo
Ixesha (umzu) A% B%
0.00 90 10
12.00 10 90
15.00 10 90
15.01 90 10
20.00 90 10
6.6 Ukulungiswa kwesisombululo sesampuli
Ubunzima kwaye uchithe isampuli ye-0.1g kunye ne-acetonitrile, i-dilute ukuya kwi-100m1, xubha kakuhle ukusetyenziswa, okanye ukugxila okufanayo.Lungiselela iisampuli ezimbini ngokuhambelanayo.
6.7 Ukumiselwa kweSampuli
Hlalutya isampuli ngokwenkqubo yesampulu ilandelayo:
Ngaphezulu kwesitofu esinye sesisombululo esingenanto
1 isampulu yenaliti isisombululo 1#
1 isampuli yenaliti isisombululo 2#
6.8 Ubalo lweziphumo
2.8.1 Indlela yokulinganisa indawo eyincopho yasetyenziselwa ukubala ukucoceka kweHPLC ngokutsala indawo engenanto.
2.8.2 Ukutenxa kuthetha ukutenxa kococeko lweenaliti ezimbini aziyi kuba nkulu kune-1%
2.8.3 Ukuba iziphumo zazo zombini iinaliti ziyahlangabezana nemilinganiselo yokwamkelwa, ucoceko oluqhelekileyo luthathwa njengesiphumo sokugqibela.
Iphakheji: Ibhotile eFluorinated, 25kg/bag, 25kg/Cardboard Drum, okanye ngokwemfuno yomthengi.
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Ukuthenga njani?Nceda uqhagamshelaneDr. Alvin Huang: sales@ruifuchem.com or alvin@ruifuchem.com
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Ukusetyenziswa kwe-D-Phenylalanine (CAS: 673-06-3)
I-D-Phenylalanine yi-D-enantiomer ye-phenylalanine.Yiphenylalanine kunye ne-D-alpha-amino acid.I-D-Phenylalanine yinto ebaluleke kakhulu ye-chiral ephakathi kwi-organic synthesis, esetyenziswa ngokubanzi kuphuhliso olutsha lwamachiza, ukuhlanganiswa kwe-polypeptide compounds kunye nezinye i-pharmaceutical intermediates.Kwaye ngenxa ye-D-Phenylpropyl amino acid ngokwayo isakhiwo kunye nomsebenzi okhethekileyo, uye watsala umdla wabantu abaninzi.I-Shanghai Ruifu Chemical Co., Ltd. ngumenzi okhokelayo kunye nomthengisi we-D-Phenylalanine e-China.
1. Ukusetyenziswa okuphambili kwe-D-Phenylalanine njengesongezelelo sezempilo kukukhululeka kokungahambi kakuhle.Isenokunceda nasekuxhaseni imisebenzi yemithambo-luvo nedibeneyo.I-D-Phenylalanine inokuthintela ukungaphumeleli komzimba womntu, ine-antipyretic kunye ne-analgesic action.
2. I-D-Phenylalanine yindawo ephakathi yamayeza esetyenziselwa unyango kunye nokuthintela i-osteoporosis, i-cardiovascular, isifo seswekile, i-arteriosclerosis kunye nezinye izifo.
3. I-D-Phenylalanine Isetyenziswa njenge-pharmaceutical intermediate okanye i-API ukudibanisa amachiza afana ne-Nateglinide.Umbindi ongundoqo wamachiza e-HIV protease depressant;imathiriyeli ekrwada yamachiza amatsha okulwa nomhlaza kunye namachiza okunyanga isifo seswekile
4. I-D-Phenylalanine nayo ingasetyenziswa njengesongezo sokutya, i-agent emnandi.
5. I-D-Phenylalanine yi-inhibitor ye-enzymes engasebenzi i-enkephalins.I-Enkephalins iyenzeka ngokwemvelo njenge-peptides efana ne-morphine esebenza ukunciphisa intlungu.Ngokuthintela i-enzymes kwi-enkephalins ehlazisayo, i-D-Phenylalanine inokunciphisa ubunzima beentlungu.
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