I-DAPT (GSI-IX) CAS 208255-80-5 γ-Secretase Inhibitor Assay >98.0% (HPLC) Factory
I-Shanghai Ruifu Chemical Co., Ltd. ngumenzi ohamba phambili we-DAPT (GSI-IX) (CAS: 208255-80-5) kunye nomgangatho ophezulu, γ-Secretase Inhibitor.I-Ruifu Chemical ibonelela ngothotho lwee-amino acids kunye nezinto eziphuma kuzo.Sinokubonelela ngeenkonzo zehlabathi, ezincinci kunye nezixa ezininzi ezikhoyo.Thenga iDAPT,Please contact: alvin@ruifuchem.com
| Igama leMchiza | I-DAPT |
| Izithethantonye | GSI-IX;γ-Secretase Inhibitor IX;i-gamma-Secretase Inhibitor;I-LY-374973;(3,5-Difluorophenylacetyl)-Ala-Phg-OtBu;(3,5-Difluorophenylacetyl)-L-Alanyl-L-2-Phenylglycine tert-Butyl Ester;N-[N-(3,5-Difluorophenacetyl)-L-Alanyl]-S-Phenylglycine t-Butyl Ester;(2S)-N-[2-(3,5-Difluorophenyl)acetyl]-L-Alanyl-2-Phenyl-glycine 1,1-Dimethylethyl Ester |
| Ubume beStokhwe | Ikhona evenkileni |
| Inombolo yeCAS | 208255-80-5 |
| Ifomula yeemolekyuli | I-C23H26F2N2O4 |
| Ubunzima beMolekyuli | 432.47 |
| Ukuxinana | 1.213 g/cm3 |
| Indawo yokunyibilika | 142.0 ~ 146.0℃ |
| Inovakalelo | Ubushushu Bubuthathaka |
| Ukunyibilika | Inyibilika kwi-DMSO |
| Ugcino Temp. | Gcina kwi-2-8℃ |
| I-COA kunye ne-MSDS | Iyafumaneka |
| Uphawu | Ruifu Chemical |
| Iingxelo zoKhuseleko | 24/25 - Gwema ukudibana nolusu kunye namehlo. | ||
| WGK eJamani | 3 | Ikhowudi ye-HS | 2922491990 |
| Izinto | ImiGangatho yokuHlola | Iziphumo |
| Imbonakalo | Umgubo weCrystalline oMhlophe okanye oMhlophe | Iyahambelana |
| Ilahleko ekomisweni | <0.40% | 0.21% |
| Intsalela kwi-Ignition | <0.40% | 0.20% |
| Iintsimbi ezinzima (njenge Pb) | ≤20ppm | <20ppm |
| Indlela yoVavanyo / yoHlahlelo | >98.0% (HPLC) | 98.62% |
| Ikhabhoni ngohlalutyo lwe-Elemental | 62.1~64.1% | Iyahambelana |
| Nitrogen ngohlalutyo lwe-Elemental | 6.20~6.70% | Iyahambelana |
| I-Infrared Spectrum | Iyahambelana neSakhiwo | Iyahambelana |
| NMR Spectrum | Iyahambelana neSakhiwo | Iyahambelana |
| Ukuqukumbela | Le Mveliso ngokuHlolwa kweZivumelwano kunye noMgangatho woShishino | |
| Beka ubomi kwishelufa | Iinyanga ezingama-24 ukusuka kumhla wokuveliswa ukuba zigcinwe ngokufanelekileyo | |
Iphakheji: Ibhotile eFluorinated, iAluminium foil bag, 25kg/Cardboard Drum, okanye ngokwemfuno yomthengi.
Imeko yoGcino:Gcina kwizikhongozeli ezivaliweyo kwindawo epholileyo, eyomileyo (ivenkile ekwi-2-8℃) kunye nendawo yokugcina umoya ekude kwizinto ezingahambelaniyo.Khusela ukukhanya kunye nokufuma.
Ukuthenga njani?Nceda uqhagamshelaneDr. Alvin Huang: sales@ruifuchem.com or alvin@ruifuchem.com
Amava Eminyaka Eli-15?Sineminyaka engaphezu kwe-15 yamava ekwenziweni nasekuthumeleni kumazwe angaphandle uluhlu olubanzi oluphezulu lwamayeza aphakathi okanye amachiza alungileyo.
Iimarike eziphambili?Thengisa kwimarike yasekhaya, eMntla Melika, eYurophu, eIndiya, eKorea, eJapan, eOstreliya, njl.
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UmgangathoIsiqinisekiso?Inkqubo yokulawula umgangatho ongqongqo.Izixhobo zobuchwephesha zokuhlalutya ziquka i-NMR, LC-MS, GC, HPLC, ICP-MS, UV, IR, OR, KF, ROI, LOD, MP, Clarity, Solubility, Microbial limit test, njl.
Iisampulu?Uninzi lweemveliso zibonelela ngeesampulu zasimahla zokuvavanya umgangatho, iindleko zokuthumela kufuneka zihlawulwe ngabathengi.
Factory Audit?Uphicotho-zincwadi lwasefektri wamkelekile.Nceda wenze idinga kwangaphambili.
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Amaxwebhu?Emva kwenkonzo yokuthengisa: I-COA, i-MOA, i-ROS, i-MSDS, njl.
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Immimiselo yokuhlawula?I-invoyisi yeProforma iya kuthunyelwa kuqala emva kokuqinisekiswa kwe-odolo, efakwe kwiinkcukacha zethu zebhanki.Intlawulo nge-T / T (i-Telex Transfer), i-PayPal, i-Western Union, njl.
I-DAPT (GSI-IX) (i-CAS: 208255-80-5), i-inhibitor enamandla kunye neyodwa ye-γ-secretase.I-DAPT yi-inhibitor ye-γ-secretase (IC50 kwi-neurons ephambili yomntu = i-115 nM ye-Aβ iyonke okanye i-200 nM ye-Aβ42 ngokukodwa).Ukulawulwa komlomo kwe-DAPT kuboniswe ukunciphisa amanqanaba e-Aβ kwi-brain extract, i-cerebrospinal fluid kunye ne-plasma evela kwiigundane kunye neegundane.I-DAPT ivimba i-Notch signaling ekhuthaza ukuhlukana kwe-neuronal yeeseli zangaphambili.Ukuphucula iiseli ze-iPS ngaphandle kwe-oncogenes KLF4 kunye ne-CMYC5.Iseli iyangena.I-DAPT isetyenziselwa ukufunda ukubunjwa kwe-β-amyloid.I-DAPT ibonakaliswe ukuba inqanda ukubonakaliswa kwe-Notch kwizifundo ze-autoimmune kunye nezifo ze-lymphoproliferative, ezifana ne-ALPS kunye ne-lupus erythematosus, kunye nokukhula kweeseli zomhlaza, i-angiogenesis, kunye nokwahlula kweeseli ze-stem ze-pluripotent ezenziwe ngabantu.Ithintela ukubonakaliswa kweNotch kwi-vitro.Ivimbela i-Aβ epheleleyo kunye ne-Aβ42 imveliso kwiinkcubeko eziphambili zabantu (amaxabiso e-IC50 yi-115 kunye ne-200 nM, ngokulandelanayo) ngaphandle kwempembelelo kumanqanaba e-APPα kunye ne-APPβ.Umqobo wegazi-ubuchopho uyangena.Inxalenye ye-3D ye-matrix yokuKhula kunye nenxalenye ye-cerebral organoid yokwahlula imidiya.
