Decitabine CAS 2353-33-5 Ubunyulu > 99.5% (HPLC) Factory
I-Shanghai Ruifu Chemical Co., Ltd. ngumenzi ohamba phambili kunye nomthengisi we-Decitabine (CAS: 2353-33-5) kunye nomgangatho ophezulu.Sinokubonelela nge-COA, ukuhanjiswa kwehlabathi jikelele, ubuninzi obuncinci kunye nobuninzi obukhoyo.Ukuba unomdla kule mveliso, nceda uthumele ulwazi oluneenkcukacha lubandakanya inombolo ye-CAS, igama lemveliso, ubuninzi kuthi.Please contact: alvin@ruifuchem.com
| Igama leMchiza | Decitabine |
| Izithethantonye | 5-Aza-2'-Deoxycytidine;5-Aza-1-(2-Deoxy-β-D-Ribofuranosyl)cytosine;5-Aza-CdR;5-Aza-dC;5-Deoxy-2'-Azacytidine;ZdCyd;I-DAC;β-Decitabine |
| Inombolo yeCAS | 2353-33-5 |
| Inombolo yeCAT | RF2728 |
| Ubume beStokhwe | Kwi-Stock, iMveliso yoMveliso ukuya kwiiToni |
| Ifomula yeemolekyuli | I-C8H12N4O4 |
| Ubunzima beMolekyuli | 228.21 |
| Indawo yokunyibilika | 191℃(ngoDisemba) |
| Inovakalelo | Ukungeva kuMoya, Ubushushu abuva |
| Ukunyibilika | Ichithwe kwi-DMSO;Inyibilika kancinane emanzini |
| Uphawu | Ruifu Chemical |
| Into | Iinkcukacha |
| Imbonakalo | Umgubo weCrystalline oMhlophe okanye oMhlophe |
| Isazisi A | IR: Isampulu ye-IR Spectrum ingqinelana naleyo yoMgangatho |
| Isazisi B | I-HPLC: I-RT yeNqanaba eliPhezulu leSisombululo soVavanyo sihambelana nesoMgangatho weSisombululo |
| Isazisi C | PXRD: Ilungile |
| Ubunyulu / Indlela yokuHlalutya | >99.5% (HPLC) |
| Alpha | +56.0 ° ~ 63.0 ° |
| Ilahleko ekomisweni | <0.50% |
| Intsalela kwi-Ignition | <0.10% |
| Iintsimbi ezinzima | <20ppm |
| Izinto ezinxulumeneyo | |
| α-Decitabine | <0.20% |
| Ukungcola Okungaziwayo Ongatshatanga | <0.20% |
| Ukungcola ngokupheleleyo | <0.50% |
| Izinyibilikisi ezishiyekileyo | |
| I-DMSO | <0.50% |
| IMethanol | <0.30% |
| IMethyl Formate | <0.05% |
| Acetonitrile | <0.041% |
| Ukunyibilika | I-Colorless Clear 50 mg / ml, i-HOAc kunye ne-H2O (1: 1) Dlula |
| Umgangatho woVavanyo | Umgangatho woShishino |
Iphakheji: Ibhotile, ingxowa yefoyile yeAluminiyam, 25kg/Igubu lekhadibhodi, okanye ngokwemfuno yomthengi
Imeko yoGcino:Gcina kwizikhongozeli ezivaliweyo kwindawo epholileyo neyomileyo;Khusela ukukhanya kunye nokufuma
Ukuthenga njani?Please contact: sales@ruifuchem.com or alvin@ruifuchem.com
Amava Eminyaka Eli-15?Sineminyaka engaphezu kwe-15 yamava ekwenziweni nasekuthumeleni kumazwe angaphandle uluhlu olubanzi oluphezulu lwamayeza aphakathi okanye amachiza alungileyo.
Iimarike eziphambili?Thengisa kwimarike yasekhaya, eMntla Melika, eYurophu, eIndiya, eRashiya, eKorea, eJapan, eOstreliya, njl.
Iingenelo?Umgangatho ophezulu, ixabiso elifikelelekayo, iinkonzo zengcali kunye nenkxaso yobugcisa, ukuhanjiswa ngokukhawuleza.
UmgangathoIsiqinisekiso?Inkqubo yokulawula umgangatho ongqongqo.Izixhobo zobuchwephesha zokuhlalutya ziquka i-NMR, LC-MS, GC, HPLC, ICP-MS, UV, IR, OR, KF, ROI, LOD, MP, Clarity, Solubility, Microbial limit test, njl.
Iisampulu?Uninzi lweemveliso zibonelela ngeesampulu zasimahla zokuvavanya umgangatho, iindleko zokuthumela kufuneka zihlawulwe ngabathengi.
Factory Audit?Uphicotho-zincwadi lwasefektri wamkelekile.Nceda wenze idinga kwangaphambili.
MOQ?Akukho MOQ.Umyalelo omncinci wamkelekile.
Ixesha lokuzisa? Ukuba ngaphakathi kwesitokhwe, ukuhanjiswa kweentsuku ezintathu kuqinisekisiwe.
Ezothutho?Nge-Express (FedEx, DHL), ngoMoya, ngoLwandle.
Amaxwebhu?Emva kwenkonzo yokuthengisa: I-COA, i-MOA, i-ROS, i-MSDS, njl.
Udibaniso lweSiko?Inokubonelela ngeenkonzo zesiko lokudibanisa ukuze zilungele iimfuno zakho zophando.
Immimiselo yokuhlawula?I-invoyisi yeProforma iya kuthunyelwa kuqala emva kokuqinisekiswa kwe-odolo, efakwe kwiinkcukacha zethu zebhanki.Intlawulo nge-T / T (i-Telex Transfer), i-PayPal, i-Western Union, njl.
I-Decitabine (i-CAS: 2353-33-5) (igama lokurhweba i-Dacogen), okanye i-5-Aza-2'-Deoxycytidine.Ngokwemichiza, yi-analog ye-cytidine.I-Decitabine yi-agent ye-hypomethylating.I-Decitabine iqaliswe kunyango lwe-myelodysplastic syndromes (MDS).I-MDS yiseti yeengxaki ze-hematologic ezichaphazela umongo wethambo obangela ukungasebenzi kakuhle kunye nokuphuhliswa kweeseli zegazi.Ngaphezu koko, izigulane ezine-MDS zinomngcipheko omkhulu wokuqhubela phambili kwi-acute myeloid leukemia (AML).Unyango lwemveli lubandakanya utofelo-gazi, izinto zokukhula kwe-hematopoietic, kunye ne-prophylactic antibiotics, kodwa la manyathelo aphucula nje umgangatho wobomi kunye neziphumo ezithandabuzekayo ekuguqulweni kwesifo.Ngelixa i-stem-cell transplantation yindlela enobudlova, enokuthi iphilise, ubudala obudala okanye eminye imiba yezempilo enzima yezigulane ezininzi zibavimbela ukuba baqwalasele olu khetho.Inkqubela phambili yakutsha nje kwi-etiology esisiseko ye-MDS, nangona kunjalo, ikhokelele ekuphuhliseni udidi olutsha lweekhompawundi ezaziwa ngokuba yi ''demethylating agents''.I-Decitabine ilandela ukuqaliswa ngempumelelo kwe-DNA methyltransferase inhibitor yokuqala ye-Azacitidine.I-hypomethylates i-DNA ngokuthintela i-DNA methyltransferase.Isebenza ngendlela efanayo ne-Azacitidine, nangona i-decitabine ingabandakanywa kuphela kwimicu ye-DNA ngelixa i-azacitidine inokuthi ifakwe kwimixokelelwane ye-DNA kunye ne-RNA.Ama-reagents ophando: I-Decitabine isetyenziswa ngokubanzi kwi-biology ye-molecular, i-pharmacology, kunye nolunye uphando lwesayensi.I-Decitabine njenge-inhibitor ye-DNA methyltransferase inhibitor, inkqubo ye-DNA methylation eguqulwayo, ibangele iiseli ze-tumor kwiiseli eziqhelekileyo zokwahlula okanye zenze i-tumor cell apoptosis.Nceda uqaphele ukuba i-concentration ephezulu ye-Decitabine iya kudlala umphumo wayo we-cytotoxic: inokuthintela i-DNA synthesis eyenza ukufa kweeseli.
