I-Desmopressin Acetate CAS 16789-98-3 Peptide Purity (HPLC) ≥98.5% Factory

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I-Desmopressin Acetate (CAS: 16789-98-3) oko kukuthi, i-1-cysteine ​​deamination kunye ne-8-D-arginine endaweni ye-8-l-arginine, eyaziwa ngokuba yi-arginine vasopressin, i-analog yesakhiwo se-arginine vasopressin yendalo, i-derivative of i-vasopressin, i-antidiuretic effect inamandla ngakumbi kwaye ihlala ixesha elide kune-vasopressin, kodwa akukho siphumo se-vasoconstrictor, imiphumo emibi yeziyobisi, iklinikhi yokukhubazeka kweplatelet yokuzalwa okanye iziyobisi, i-uremia, i-cirrhosis yesibindi kunye nezizathu ezingaziwayo ezibangelwa kukuphuma kwexesha elide;Ingasetyenziselwa ukulawula nokuthintela ukopha ngexesha lotyando oluncinci;Isifo seswekile esisembindini i-insipidus.Kwiimeko zomntu ngamnye, le mveliso iya kuvelisa ukusebenza kakuhle kwizigulane ezinezifo zenkqubo yomchamo, zihlala zikhubazekile kwizigulane ezine-Type IIB von Willebrand isifo.
Isenzo se-Pharmacological: I-Desmopressin Acetate iqulethe i-desmopressin enesakhiwo esifana ne-arginine vasopressin yokuzalwa.Ngumahluko phakathi kwe-arginine vasopressin, ngokukodwa kwisiqingatha se-amino acid kunye ne-D arginine ukuze ithathe indawo ye-L Arginine.Olu tshintsho lwesakhiwo lwandisa ubude bexesha ledosi yekliniki ye-desmopressin ngaphandle kweziphumo ebezingalindelekanga zoxinzelelo.Olunye uphando lubonise ukuba impembelelo ye-anti-enuresis ibalulekile, enokuthi ibe ngenxa yokunyuka kwamanqanaba e-arginine vasopressin egazini labantwana ebusuku, kwaye emva koko ugxininise umchamo, unciphise umthamo womchamo kunye noxinzelelo lwe-intravascular, ukuncipha kwentamo kunye noxinzelelo lwegazi. ukuncipha kwe-detrusor.
Ukusebenza kwayo, ukulula kolawulo (intranasal), ixesha elide lesenzo, kunye nokungabikho kweziphumo ebezingalindelekanga kuyenza ibe lichiza elikhethwayo kunyango lwe-diabetesinspidus ephakathi.Isenokwenziwa kwakhona nge-intramuscularly ortravenously.Kukhethwa ukuba kusetyenziswe inaliti ye-vasopressin kunye ne-antidiuretics yomlomo ukuze isetyenziswe ebantwaneni.Kuboniswa ekulawuleni i-polydipsia yethutyana kunye ne-polyuria ehambelana nokwenzakala, okanye utyando, kwingingqi ye-pituitary.
Ukusetyenziswa kwezonyango: I-Desmopressin, njengetyuwa ye-acetate, yi-analogue yokwenziwa ye-vasopressin apho i-Cys ye-N terminal ingenawo umsebenzi wayo we-α-amino (1-Deamino) kwaye apho i-Arg8 ikhona njenge-D-isomer (D-Arg8) , ngoko ke i-acronym yorhwebo i-DDAVP.Ubukho be-D-Arg kunye nokungabikho kwe-amine ye-N-terminal kwisakhiwo se-desmopressin kwandisa i-half-life yayo kangangokuba ifumaneka ngomlomo, i-parenteral, okanye i-nasal.Isetyenziswe zizo zonke ezi zintathu zeendlela zokulawula ukukhusela okanye ukulawula i-polydipsia (unxano olugqithisileyo), i-polyuria, kunye nokuchithwa kwezigulane ezine-diabetes insipidus ezibangelwa ukungabikho kwe-vasopressin.Kwakhona kuye kwavunywa unyango lwe-enuresis yasebusuku (i-bed-wetting), ekukholelwa ukuba ibangelwa ukungabikho kokunyuka kwexesha eliqhelekileyo ebusuku kumanqanaba e-vasopressin.I-Desmopressin yaziwa ngokubangela ukwanda kwi-plasma factor VIII (antihemophilic factor) kunye ne-activator ye-plasminogen.Ngoko ke ivunyiwe yi-US FDA ukuba isetyenziswe, ngokuzala kunye nangempumlo, ekunciphiseni iziqephu ezophayo ezizenzekelayo okanye ezibangelwa yintlungu kwizigulane ezine-hemophilia A kunye nohlobo lwe-I yesifo sika-Von Willebrand, ngaphandle kokuba umsebenzi wabo we-plasma factor VIII mkhulu kune-5%.Uqikelelo, i-spray yeempumlo esetyenziselwa ukunyanga izigulane ezine-hemophilia A kunye nohlobo lwe-Von Willebrand's disease, i-15-fold concentration ye-DDAVP yokutshiza ngeempumlo;le yokugqibela isetyenziselwa ukunyanga isifo seswekile insipidus.