I-Diethylphosphonoacetic Acid CAS 3095-95-2 Ubunyulu >99.5% (HPLC) I-Afatinib Dimaleate iFactory Intermediate Factory Featured Image

I-Diethylphosphonoacetic Acid CAS 3095-95-2 Ubunyulu >99.5% (HPLC) I-Afatinib Dimaleate Intermediate Factory

Inkcazelo emfutshane:

Igama leKhemikhali: I-Diethylphosphonoacetic Acid

CAS: 3095-95-2

Ubunyulu: >99.5% (HPLC)

Imbonakalo: Ulwelo olungenambala

Phakathi kwe-Afatinib Dimaleate (CAS: 850140-73-7)

Umgangatho ophezulu, iMveliso yoRhwebo

E-Mail: alvin@ruifuchem.com

Thumela i-imeyile kuthi

Iinkcukacha zeMveliso

Iimveliso ezinxulumeneyo

Iithegi zeMveliso

Inkcazo:

I-Ruifu Chemical Supply Intermediates ye-Afatinib
Afatinib CAS 439081-18-2
Afatinib Dimaleate CAS 850140-73-7
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(Dimethylamino)i-acetaldehyde I-Diethyl Acetal CAS 3616-56-6
trans-4-Dimethylaminocrotonic Acid Hydrochloride CAS 848133-35-7
I-Diethylphosphonoacetic Acid CAS 3095-95-2
7-Fluoro-6-Nitroquinazolin-4 (1H)-enye CAS 162012-69-3
I-7-Chloro-6-Nitro-4-Hydroxyquinazoline CAS 53449-14-2
N-(3-Chloro-4-Fluorophenyl)-7-Fluoro-6-Nitroquinazolin-4-Amine CAS 162012-67-1
(S)-N4-(3-Chloro-4-Fluorophenyl)-7-((Tetrahydrofuran-3-yl)oxy)quinazoline-4,6-DiamineI-CAS 314771-76-1
(S)-N-(3-Chloro-4-Fluorophenyl)-6-Nitro-7-((Tetrahydrofuran-3-yl)oxy)quinazolin-4-AmineI-CAS 314771-88-5

Iipropati zeMichiza:

Igama leMchiza	I-Diethylphosphonoacetic Acid
Izithethantonye	I-2-(Diethoxyphosphoryl)i-acetic Acid;(Diethoxyphosphinyl)iAcetic Acid;I-Diethyl Carboxymethylphosphonate;NSC 272281
Inombolo yeCAS	3095-95-2
Inombolo yeCAT	RF-PI2024
Ubume beStokhwe	Kwi-Stock, iMveliso yeMveliso ye-30MT / ngenyanga
Ifomula yeemolekyuli	(C2H5O)2P(O)CH2CO2H
Ubunzima beMolekyuli	196.14
Indawo yokubilisa	150℃/0.05 mmHg (lit.)
Ukuxinana	1.220 g/mL ku-25℃ (lit.)
Refractive Index	n20/D 1.445 (lit.)
Uphawu	Ruifu Chemical

Iinkcukacha:

Into	Iinkcukacha
Imbonakalo	Ulwelo olungenambala
Ukuchongwa (HPLC)	Ixesha lokugcinwa kwencopho ephambili efunyenwe kwisampulu ingaphakathi kwe-5% yesampulu yereferensi.
Ubunyulu / Indlela yokuHlalutya	>99.5% (HPLC)
I-Infrared Spectrum	Iyahambelana neSakhiwo
Proton NMR Spectrum	Iyahambelana neSakhiwo
Ukufuma (KF)	<0.50%
Ukungcola ngokupheleleyo	<0.50%
Umgangatho woVavanyo	Umgangatho woShishino
Ukusetyenziswa	Phakathi kwe-Afatinib Dimaleate (CAS: 850140-73-7)

Ukupakishwa kunye noGcino:

Iphakheji: Ibhotile eFluorinated, 25kg/ Igubu, okanye ngokwemfuno yomthengi

Imeko yoGcino:Gcina kwizikhongozeli ezivaliweyo kwindawo epholileyo neyomileyo;Khusela ukukhanya kunye nokufuma

Izinto eziluncedo:

FAQ:

Isicelo:

I-Diethylphosphonoacetic Acid (CAS: 3095-95-2), Isebenza njenge-nucleophile ye-nucleophilic reaction reactions for synthesis of allene epoxides I-Reactant for: Izifundo ze-Stereoselectivity ze-Staudinger reaction;Ukwenziwa kwe-Enantioselective yee-diols nge-epoxidation kunye ne-hydration reactions;Horner-Wadsworth-Emmons iimpendulo;Remote chelation controlled Ireland-Claisen rearrangement;Ugi-Dieckmann reactions for synthesis of tetramic acid derivatives;Isetyenziselwa ukwenza i-phosphonoester intermediates kwi-intramolecular HEW reactions.I-Diethylphosphonoacetic Acid iphakathi kwe-Afatinib Dimaleate (CAS: 850140-73-7).I-Afatinib Dimaleate yavunywa yi-US Food and Drug Administration (FDA) kwi-2013 yonyango lwe-non-small cell lung cancer (NSCLC).Ngokukodwa, yamkelwa kwizigulana ezibonisa i-metastatic NSCLC tumors equlathe ukucinywa kwe-epidermal growth factor receptor (EGFR) okanye ukuguqulwa kwe-exon 21.I-Afatinib Dimaleate yi-covalent inhibitor ye-ErbB tyrosine kinases (tyk), eyehlisa umqondiso we-ErbB ngokubophelela ngokungenakuguquleka kweendawo ezibophelelayo ze-EGFR tyk.